Results 51 to 60 of about 45,129 (213)

Optimising Age‐Specific Insulin Signalling to Slow Down Reproductive Ageing Increases Fitness in Different Nutritional Environments

Aging Cell, Volume 24, Issue 5, May 2025.
We found that reducing insulin signalling in adult worms slows down their reproductive ageing and extends their lifespan without negative side effects. Moreover, combining it with IF further enhances these benefits. These interventions likely work by regulating genes linked to biosynthesis and immunity, showing how optimising gene expression can delay ...
Zahida Sultanova, Aykut Shen, Katarzyna Hencel, Hanne Carlsson, Zoe Crighton, Daniel Clifton, Alper Akay, Alexei A. Maklakov   +7 more
wiley   +1 more source

Targeting CRM1 for Progeria Syndrome Therapy

Aging Cell, Volume 24, Issue 5, May 2025.
Pharmacological inhibition of CRM1 mediated by selinexor, the first‐in‐class selective inhibitor of CRM1, mitigates the senescent phenotype of Hutchinson‐Gilford progeria syndrome (HGPS) patients‐derived primary fibroblasts. Treatment of HGPS fibroblasts with selinexor promotes the clearances of progerin via autophagy activation, restores the ...
Adriana Soto‐Ponce, Marlon De Ita, Susana Castro‐Obregón, Diego Cortez, Yosef Landesman, Jonathan J. Magaña, Susana Gonzalo, Tania Zavaleta, Angelica Soberano‐Nieto, Juan Unzueta, Isabel Arrieta‐Cruz, Porfirio Nava, Aurora Candelario‐Martínez, Ian García‐Aguirre, Bulmaro Cisneros   +14 more
wiley   +1 more source

Age‐Dependent Regulation of Hippocampal Inflammation by the Mitochondrial Translocator Protein in Mice

Aging Cell, EarlyView.
The role of mitochondrial translocator protein (TSPO) in hippocampal inflammation is age‐dependent, with TSPO deletion drastically exacerbating inflammation in aged mice, while dampening it in young mice. This TSPO–aging interaction was linked to NF‐kβ and interferon regulatory transcriptional networks. TSPO deletion exacerbated age‐dependent depletion
Kei Onn Lai, Jia Hui Wong, Nevin Tham, Lauren Fairley, Roshan Ratnakar Naik, Yulan Wang, Sarah R. Langley, Anna M. Barron   +7 more
wiley   +1 more source

The Proprotein Convertase BLI‐4 Is Required for Axenic Dietary Restriction Mediated Longevity in Caenorhabditis elegans

Aging Cell, EarlyView.
In ADR‐induced longevity in C. elegans, neuronal BLI‐4 processes neuropeptides, which are then released with the assistance of UNC‐31 and GOLG‐2. ABSTRACT Dietary restriction (DR) is a well‐established method for extending lifespan across various species, including C. elegans.
Ping Wu, Lieselot Vandemeulebroucke, Huaihan Cai, Bart P. Braeckman   +3 more
wiley   +1 more source

Accumulation of GSK‐3β in Interneurons Impairs Adult Hippocampal Neurogenesis by Inhibiting GABAergic Transmission

Aging Cell, EarlyView.
Overexpression of GSK‐3β in DG GABAergic neurons impairs neurogenesis by reducing GABA release, which can be reversed by enhancing GABAergic transmission. ABSTRACT The activation of glycogen synthase kinase 3β (GSK‐3β) and the deterioration of spatial memory represent prominent pathological and clinical manifestations of Alzheimer's disease (AD ...
Fei Liu, Jiu‐Jing Cui, Xiao‐Lin Li, Zeng‐Min Zhang, Shao‐Hua Liang, Yi Sun, Jing‐Min Li, Hong‐Lin Qu, Jing Ye, Qi‐Peng Guo, Quan Zheng, Yong‐Feng Liu   +11 more
wiley   +1 more source

Mechanisms of alcohol influence on fear conditioning: A computational model

Alcohol, Clinical and Experimental Research, EarlyView.
Computational models can test mechanistic relationships between fear conditioning, neuroadaptations, and alcohol. Simulated fear extinction is slower and less robust under alcohol, as greater basolateral amygdala activation is needed. Alcohol shifts the amygdala network away from robust extinction by inhibiting central amygdala activity.
Adam Lonnberg, Marian L. Logrip, Alexey Kuznetsov   +2 more
wiley   +1 more source

Altered activity within the social behavior neural network in adolescent rats following prenatal alcohol exposure and/or early‐life adversity

Alcohol, Clinical and Experimental Research, EarlyView.
Prenatal alcohol exposure (PAE) and early‐life adversity (ELA) independently and interactively disrupted neural activity within the social behavior network in adolescent rats, with age‐ and sex‐specific effects. PAE primarily dampened amygdala activity, while ELA altered medial prefrontal cortex responses. These findings reveal how different early‐life
Parker J. Holman, Linda Ellis, Amanda Chao, Cecilia Mitchell, Charlis Raineki, Joanne Weinberg   +5 more
wiley   +1 more source

Single-cell genomics meets systems neuroscience: Insights from mapping the brain circuitry of stress. [PDF]

J Neuroendocrinol
Abstract Responses to external and internal dangers is essential for survival and homeostatic regulation. Hypothalamic corticotropin‐releasing hormone neurons (CRHNs) play a pivotal role in regulating neuroendocrine responses to fear and stress.
Hanchate NK.
europepmc   +2 more sources

Human Pulmonary Neuroendocrine Cells Respond to House Dust Mite Extract With PAR‐1 Dependent Release of CGRP

Allergy, Volume 80, Issue 4, Page 976-985, April 2025.
This study aimed to develop and characterize an in vitro human PNEC model and investigated the neuroendocrine response to HDM extract. Exposure to HDM leads to dose‐dependent induction of the CGRP encoding gene, CALCB, and corresponding release of the neuropeptide.
Ritu Mann‐Nüttel, Shivani Mandal, Marie Armbruster, Lakshmi Puttagunta, Paul Forsythe   +4 more
wiley   +1 more source

The Direct and Indirect Role of IgE on Airway Epithelium in Asthma

Allergy, Volume 80, Issue 4, Page 919-931, April 2025.
ABSTRACT Asthma is a chronic airway inflammatory disorder, affecting over 350 million people worldwide, with allergic asthma being the most common form of the disease. Allergic asthma is characterized by a type 2 (T2) inflammatory response triggered by numerous allergens beginning in the airway epithelium, which acts as a physical barrier to allergens ...
Christian Domingo, William W. Busse, Nicola A. Hanania, Muyesser Ertugrul, Lauren A. Millette, Tina Maio‐Twofoot, Xavier Jaumont, Oscar Palomares   +7 more
wiley   +1 more source