Results 101 to 110 of about 17,164 (224)

Design of a cyclotide antagonist of neuropilin-1 and-2 that potently inhibits endothelial cell migration

, 2013
Neuropilin-1 and -2 are critical regulators of angiogenesis, lymphangiogenesis, and cell survival as receptors for multiple growth factors. Disulfide-rich peptides that antagonize the growth factor receptors neuropilin-1 and neuropilin-2 were developed ...
Cheneval, Olivier, Craik, David J., Daugherty, Patrick S., Getz, Jennifer A.   +3 more
core   +1 more source

Expression of Semaphorin 3F and Its Receptors in Epithelial Ovarian Cancer, Fallopian Tubes, and Secondary Müllerian Tissues

Obstetrics and Gynecology International, 2009
While semaphorins and their receptors appear to play a role in tumor carcinogenesis, little is known about the role of semaphorin 3F (S3F) in epithelial ovarian cancer (EOC) development. Therefore, we sought to determine the clinical relationship between
Christina D. Drenberg, Sandra Livingston, Ren Chen, Patricia A. Kruk, Santo V. Nicosia   +4 more
doaj   +1 more source

Human neuropilin-1 biomarker as predictor of subclinical cardiovascular affection in systemic lupus erythematosus patients

Egyptian Rheumatology and Rehabilitation
Background Cardiovascular disease (CVD) is recognized as the leading cause of death in patients with systemic lupus erythematosus (SLE). Although the pathways involved in accelerated cardiovascular disease are not yet fully understood, atherogenesis may ...
Samar Gaber Soliman, Samah Samy Yossef, Shaimaa R. Shahin, Dina Mamdoh Serag, Dalia S. Saif   +4 more
doaj   +1 more source

CRMP2 and CRMP4 Are Differentially Required for Axon Guidance and Growth in Zebrafish Retinal Neurons

Neural Plasticity, 2018
Axons are directed to their correct targets by guidance cues during neurodevelopment. Many axon guidance cues have been discovered; however, much less known is about how the growth cones transduce the extracellular guidance cues to intracellular ...
Zhi-Zhi Liu, Jian Zhu, Chang-Ling Wang, Xin Wang, Ying-Ying Han, Ling-Yan Liu, Hong A. Xu   +6 more
doaj   +1 more source

Structural studies of neuropilin-1

, 2015
Neuropilin-1 (Nrp1) is ~130kDa multidomain type I transmembrane protein with no intrinsic enzymatic activity. Instead, acting as co-receptor in conjunction with other membrane proteins such as vascular endothelial growth factor receptors VEGFRs and ...
Yelland, TS
core  

Study of Neuropilin-1/Cd304 Expression in Leukemogenesis

, 2018
Neuropilins are transmembrane glycoproteins that act as receptors for vascular endothelial growth factors (VEGF) and are involved in the process of tumor angiogenesis. Its importance in hematological malignancies such as acute leukemia (AL) remains to be
Ahmed A. Allam, Shereen P. Aziz, Elsayed Mostafa Ali   +2 more
core   +1 more source

Nrp2 is sufficient to instruct circuit formation of mitral-cells to mediate odour-induced attractive social responses

Nature Communications, 2017
Neuropilin 2 (Nrp2) is expressed by a subset of mitral cells in the postero-ventral olfactory bulb in mice. Here the authors show that Nrp2 is sufficient to instruct mitral cell targeting to the anterior part of medial amygdala that modulates olfactory ...
Kasumi Inokuchi, Fumiaki Imamura, Haruki Takeuchi, Ryang Kim, Hiroyuki Okuno, Hirofumi Nishizumi, Haruhiko Bito, Takefumi Kikusui, Hitoshi Sakano   +8 more
doaj   +1 more source

Neuropilin-2 Is a Receptor for Semaphorin IV Insight into the Structural Basis of Receptor Function and Specificity

, 1998
Neuropilins bind secreted members of the semaphorin family of proteins. Neuropilin-1 is a receptor for Sema III. Here, we show that neuropilin-2 is a receptor for the secreted semaphorin Sema IV and acts selectively to mediate repulsive guidance events ...
Ginty, David D, Urquhart, Erica Rowe, Levengood, Dorothy V, Giger, Roman J, Gillespie, Susan K.H, Kolodkin, Alex L   +5 more
core   +1 more source

Furin Processing of Semaphorin 3F Determines Its Anti-Angiogenic Activity by Regulating Direct Binding and Competition for Neuropilin

, 2016
Neuropilin is an essential cell surface receptor that functions in both semaphorin-dependent axon guidance and vascular endothelial growth factor (VEGF)-dependent angiogenesis.
Michael G. Fried (128930), Lance M. Hellman (522777), Ping Xu (122619), Craig W. Vander Kooi (122623), Matthew W. Parker (122616)   +4 more
core   +1 more source

Comparison of neuropilin-1 (NRP-1) and neuropilin-2 (NRP-2) expression in alveolar macrophages and interstitial macrophages in lung tissue remote to the cancer nest (physiologically normal lung) (n = 5).

, 2016
Comparison of neuropilin-1 (NRP-1) and neuropilin-2 (NRP-2) expression in alveolar macrophages and interstitial macrophages in lung tissue remote to the cancer nest (physiologically normal lung) (n = 5).
Hongxue Meng (2272915), Tomoya Kato (2124757), Mitsunori Yamakawa (641922), Suran Yang (2272906), Naing Ye Aung (2272909), Takanobu Kabasawa (2272912), Rintaro Ohe (641921)   +6 more
core   +1 more source