Results 141 to 150 of about 14,670 (186)
Some of the next articles are maybe not open access.
The role of neuropilins in cancer
Molecular Cancer Therapeutics, 2006Abstract Neuropilins are multifunctional non–tyrosine kinase receptors that bind to class 3 semaphorins and vascular endothelial growth factor. NRP-1 and NRP-2 were first identified for their key role in mediating axonal guidance in the developing nervous system through their interactions with class 3 semaphorins.
openaire +2 more sources
Neuropilin signalling in angiogenesis
Biochemical Society Transactions, 2012VEGFs (vascular endothelial growth factors) are master regulators of vascular development and of blood and lymphatic vessel function during health and disease in adults. This family of five mammalian ligands acts through three RTKs (receptor tyrosine kinases).
openaire +2 more sources
Endothelial neuropilin-1 and neuropilin-2 are essential for tumour angiogenesis
2022Abstract Neuropilin (NRP) expression is highly correlated with poor outcome in multiple cancer subtypes. As known co-receptors for vascular endothelial growth factor receptors (VEGFRs), core drivers of angiogenesis, past investigations have alluded to their functional roles in facilitating tumorigenesis by promoting ...
CJ Benwell +4 more
openaire +1 more source
Neuropilin-1 and neuropilin-2 act as coreceptors, potentiating proangiogenic activity
Blood, 2008Neuropilin-1 and -2 (NRP1 and NRP2) are the transmembrane glycoproteins interacting with 2 types of ligands: class III semaphorins and several members of the VEGF family, the main regulators of blood and lymphatic vessel growth. We show here that both NRP1 and NRP2 can also bind hepatocyte growth factor (HGF).
Sulpice, Eric +5 more
openaire +3 more sources
The Interaction of Neuropilin-1 and Neuropilin-2 with Tyrosine-Kinase Receptors for VEGF
2002The Neuropilin-1 (NRP1) and Neuropilin-2 (NRP2) receptors were initially described as receptors for axon guidance factors belonging to the class-3 Semaphorin sub-family. Subsequently, it was found the Neuropilins also function as receptors for some forms of vascular endothelial growth factor (VEGF).
Gera, Neufeld +2 more
openaire +2 more sources
The role of neuropilins in cell signalling
Biochemical Society Transactions, 2009NRPs (neuropilins) are receptors for class 3 semaphorins, polypeptides essential for axonal guidance, and for members of the VEGF (vascular endothelial growth factor) family of angiogenic cytokines. While mutant mouse studies show that NRP1 is essential for neuronal and cardiovascular development, little is known concerning the molecular mechanisms ...
Ian C, Zachary +3 more
openaire +2 more sources
Structural and Functional Relation of Neuropilins
2002Neuropilin is a type I transmembrane protein and the molecular mass is 120 kDa. Two homologues, Neuropilin-1 and -2, are identified. The primary structure of Neuropilin-1 and Neuropilin-2 is well conserved and is divided into four domains, CUB (a1/a2) domain, FV/FVIII (b1/b2) domain, MAM (c) domain, and (d) domain that contains a transmembrane and a ...
Fumio, Nakamura, Yoshio, Goshima
openaire +2 more sources
Neuropilins in physiological and pathological angiogenesis
The Journal of Pathology, 2007AbstractNeuropilin‐1 (Np1) and neuropilin‐2 (Np2) are transmembrane glycoproteins with large extracellular domains that interact with both class 3 semaphorins and vascular endothelial growth factor (VEGF), and are involved in the regulation of many physiological pathways, including angiogenesis. The neuropilins also interact directly with the classical
C A, Staton +3 more
openaire +2 more sources
Neuropilin and Neuropilin Associated Molecules as New Molecular Targets in Pancreatic Adenocarcinoma
Anti-Cancer Agents in Medicinal Chemistry, 2011The Neuropilin receptors are increasingly recognized as receptors for vascular endothelial growth factors like VEGF-A and VEGF-C as well as other important growth factors like HGF and FGF in human vasculature and in tumor cells. More and more studies show an important role of Neuropilin in cancer biology suggesting that these transmembrane proteins ...
openaire +2 more sources
Neuropilin-1 in the Immune System
2002The neuropilin-1 (NRP1) and neuropilin-2 (NRP2) receptors can bind the class 3 semaphorin subfamily and the heparin-binding forms of vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF). The functions of NRP1 and NRP2 have been extensively studied in neurons where they act in axon guidance and in endothelial cells where they ...
Paul-Henri, Romeo +2 more
openaire +2 more sources