Results 11 to 20 of about 2,882 (188)

Oxytocinergic Signaling in Zebrafish: Translational Perspectives for Autism Spectrum Disorder. [PDF]

J Neurochem
Alterations in oxytocin signaling are strongly implicated in the social and cognitive deficits characterizing Autism Spectrum Disorder (ASD) and other neurodevelopmental conditions. However, the precise mechanisms remain unclear. The zebrafish (Danio rerio) has emerged as a powerful translational model due to its evolutionarily conserved oxytocin ...
Peres G, Wiprich MT, Gusso D, Bonan CD.
europepmc   +2 more sources

Uncovering Hyperhomocysteinemia: Global Risk Patterns and Molecular Disruption in Brain and Vascular Health. [PDF]

J Neurochem
Elevated homocysteine results from genetic variants, impaired one‐carbon metabolism, nutritional deficiencies, and metabolic disorders. Hyperhomocysteinemia drives oxidative stress, inflammation, excitotoxicity, and epigenetic disruption, affecting multiple organs and systems.
Ramires Júnior OV, Prauchner GRK, Rieder AS, Leite AKO, Farias CP, Wyse ATS.   +5 more
europepmc   +2 more sources

A three‐range approach enhances the prognostic utility of CSF biomarkers in Alzheimer's disease

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 8, Issue 1, 2022., 2022
Abstract Introduction Alzheimer's disease consensus recommends biomarker dichotomization, a practice with well‐described clinical strengths and methodological limitations. Although neuroimaging studies have explored alternative biomarker interpretation strategies, a formally defined three‐range approach and its prognostic impact remains under‐explored ...
Wagner S. Brum, Marco Antônio de Bastiani, Andrei Bieger, Joseph Therriault, João P. Ferrari‐Souza, Andréa L. Benedet, Paramita Saha‐Chaudhuri, Diogo O. Souza, Nicholas J. Ashton, Henrik Zetterberg, Tharick A. Pascoal, Thomas Karikari, Kaj Blennow, Pedro Rosa‐Neto, Eduardo R. Zimmer, Alzheimer's Disease Neuroimaging Initiative (ADNI)   +15 more
wiley   +1 more source

Avaliação da isquemia cerebral focal induzida pela oclusão da artéria cerebral média e a ação neuroprotetora do cetoprofeno em ratos [PDF]

Arquivos de Neuro-Psiquiatria, 2000
A isquemia cerebral é fenômeno eventualmente observado durante procedimentos neurocirúrgicos e em patologias clínicas resultando em déficits neurológicos incapacitantes ou mesmo na morte.
LUIZ ANTONIO ARAUJO DIAS, BENEDICTO OSCAR COLLI, JOAQUIM COUTINHO NETTO, JOÃO JOSÉ LACHAT   +3 more
doaj   +1 more source

HIV/AIDS IMMUNEPATHOLOGY: MECHANISMS, CONTRADICTIONS AND CONTROVERSIES

Revista de Pesquisa Cuidado é Fundamental Online, 2011
Resumo: Antes de entrar na célula como uma partícula infecciosa livre, o HIV passa por contato célula a célula. A ligação do HIV ao CD4 causa alterações no gp120 e CD4 oferecendo sítios de ligação com CXR4, CXR5 e outros receptores.
Fernando Samuel Sion, Fernando Raphael de Almeida Ferry, Jorge Francisco da Cunha Pinto, Marcelo Costa Velho, Rosangela Souza Kalil, Carlos Alberto Morais de Sá   +5 more
doaj   +7 more sources

Expression of HSP70 in cerebral ischemia and neuroprotetive action of hypothermia and ketoprofen Expressão de HSP70 na isquemia cerebral e a ação neuroprotetora da hipotermia e do cetoprofeno

Arquivos de Neuro-Psiquiatria, 2010
Heat shock proteins (HSPs) are molecular chaperones that bind to other proteins to shepherd them across membranes and direct them to specific locations within a cell. Several injurious stimuli can induce Hsp70 expression, including ischemia.
Daniela Pretti da Cunha Tirapelli, Carlos Gilberto Carlotti Junior, João Pereira Leite, Luis Fernando Tirapelli, Benedicto Oscar Colli   +4 more
doaj   +1 more source

Adenosine and neuroprotection in the temporal lobe epilepsy: from A1 receptor activation to A2A receptor blockade [PDF]

, 2010
OBJECTIVE: To characterize the effect of the A2A receptor blockage by the SCH58261 in the seizure modulation and neuroprotection of the brain areas vulnerable to injury by pilocarpine.
Fernandes, Maria Jose da Silva, Persike, Daniele Suzete, Rosim, Fernanda Elisa, Silva, Iara Ribeiro, Vignoli, Thiago   +4 more
core   +3 more sources

Role of Prefrontal Cortex on Recognition Memory Deficits in Rats following 6‐OHDA‐Induced Locus Coeruleus Lesion

Oxidative Medicine and Cellular Longevity, Volume 2020, Issue 1, 2020., 2020
Degeneration of the locus coeruleus (LC), the main source of cerebral noradrenaline (NA), has been reported in diverse neurodegenerative diseases, including Parkinson’s diseases (PD). There is increasing evidence indicating the role of NA deficiency in the prefrontal cortex (PFC) and the development of early cognitive impairments in PD.
Tuane Bazanella Sampaio, Naiani Ferreira Marques, Luisa Bandeira Binder, Carla Inês Tasca, Rui Daniel Prediger, Manuela Curcio   +5 more
wiley   +1 more source

Atividade Neuroprotetora da Minociclina na Isquemia Cerebral: Revisão Sistemática [PDF]

Infarma: Pharmaceutical Sciences, 2019
O acidente vascular cerebral é causado pela interrupção do fluxo sanguíneo cerebral, podendo ser de gênese isquêmica. Os subtipos são determinados conforme a origem, podendo ser: aterosclerose de grandes artérias, cardioembolismo, oclusão de pequenas ...
Jean Pierre de Oliveira ALENCAR, Gustavo de Oliveira ALENCAR, Iri Sandro Pampolha LIMA   +2 more
doaj   +1 more source

Epilepsy and neuroprotection: employment of the RPia during status epilepticus induced by pilocarpine [PDF]

, 2008
OBJECTIVE: The aim of this study was to characterize the neuroprotection of the RPia in rats subjected to status epilepticus (SE) induced by pilocarpine (Pilo).
Blini, João Paulo, Cavalheiro, Esper Abrão, Fernandes, Maria Jose da Silva, Nehlig, Astrid, Persike, Daniele Suzete, Rosim, Fernanda Elisa, Silva, Iara Ribeiro, Sinigaglia-Coimbra, Rita, Vignoli, Thiago   +8 more
core   +2 more sources