Results 11 to 20 of about 2,570 (152)

Oxytocinergic Signaling in Zebrafish: Translational Perspectives for Autism Spectrum Disorder. [PDF]

J Neurochem
Alterations in oxytocin signaling are strongly implicated in the social and cognitive deficits characterizing Autism Spectrum Disorder (ASD) and other neurodevelopmental conditions. However, the precise mechanisms remain unclear. The zebrafish (Danio rerio) has emerged as a powerful translational model due to its evolutionarily conserved oxytocin ...
Peres G, Wiprich MT, Gusso D, Bonan CD.
europepmc   +2 more sources

Uncovering Hyperhomocysteinemia: Global Risk Patterns and Molecular Disruption in Brain and Vascular Health. [PDF]

J Neurochem
Elevated homocysteine results from genetic variants, impaired one‐carbon metabolism, nutritional deficiencies, and metabolic disorders. Hyperhomocysteinemia drives oxidative stress, inflammation, excitotoxicity, and epigenetic disruption, affecting multiple organs and systems.
Ramires Júnior OV, Prauchner GRK, Rieder AS, Leite AKO, Farias CP, Wyse ATS.   +5 more
europepmc   +2 more sources

A three‐range approach enhances the prognostic utility of CSF biomarkers in Alzheimer's disease

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 8, Issue 1, 2022., 2022
Abstract Introduction Alzheimer's disease consensus recommends biomarker dichotomization, a practice with well‐described clinical strengths and methodological limitations. Although neuroimaging studies have explored alternative biomarker interpretation strategies, a formally defined three‐range approach and its prognostic impact remains under‐explored ...
Wagner S. Brum, Marco Antônio de Bastiani, Andrei Bieger, Joseph Therriault, João P. Ferrari‐Souza, Andréa L. Benedet, Paramita Saha‐Chaudhuri, Diogo O. Souza, Nicholas J. Ashton, Henrik Zetterberg, Tharick A. Pascoal, Thomas Karikari, Kaj Blennow, Pedro Rosa‐Neto, Eduardo R. Zimmer, Alzheimer's Disease Neuroimaging Initiative (ADNI)   +15 more
wiley   +1 more source

Role of Prefrontal Cortex on Recognition Memory Deficits in Rats following 6‐OHDA‐Induced Locus Coeruleus Lesion

Oxidative Medicine and Cellular Longevity, Volume 2020, Issue 1, 2020., 2020
Degeneration of the locus coeruleus (LC), the main source of cerebral noradrenaline (NA), has been reported in diverse neurodegenerative diseases, including Parkinson’s diseases (PD). There is increasing evidence indicating the role of NA deficiency in the prefrontal cortex (PFC) and the development of early cognitive impairments in PD.
Tuane Bazanella Sampaio, Naiani Ferreira Marques, Luisa Bandeira Binder, Carla Inês Tasca, Rui Daniel Prediger, Manuela Curcio   +5 more
wiley   +1 more source

Adenosine and neuroprotection in the temporal lobe epilepsy: from A1 receptor activation to A2A receptor blockade [PDF]

, 2010
OBJECTIVE: To characterize the effect of the A2A receptor blockage by the SCH58261 in the seizure modulation and neuroprotection of the brain areas vulnerable to injury by pilocarpine.
Fernandes, Maria Jose da Silva, Persike, Daniele Suzete, Rosim, Fernanda Elisa, Silva, Iara Ribeiro, Vignoli, Thiago   +4 more
core   +3 more sources

Epilepsy and neuroprotection: employment of the RPia during status epilepticus induced by pilocarpine [PDF]

, 2008
OBJECTIVE: The aim of this study was to characterize the neuroprotection of the RPia in rats subjected to status epilepticus (SE) induced by pilocarpine (Pilo).
Blini, João Paulo, Cavalheiro, Esper Abrão, Fernandes, Maria Jose da Silva, Nehlig, Astrid, Persike, Daniele Suzete, Rosim, Fernanda Elisa, Silva, Iara Ribeiro, Sinigaglia-Coimbra, Rita, Vignoli, Thiago   +8 more
core   +2 more sources

Anestésicos, precondicionamento e proteção cerebral

Revista Brasileira de Anestesiologia, 2013
JUSTIFICATIVA E OBJETIVOS: Diversos estudos têm demonstrado o precondicionamento cerebral como mecanismo protetor diante de uma situação de estresse. Fatores determinantes são descritos, bem como a neuroproteção proporcionada por agentes anestésicos e ...
Rogean Rodrigues Nunes, Gastão Fernandes Duval Neto, Júlio César Garcia de Alencar, Suyane Benevides Franco, Nayanna Quezado de Andrade, Danielle Maia Holanda Dumaresq, Sara Lúcia Cavalcante   +6 more
doaj   +1 more source

Neuroproteção no acidente vascular celebral: opinião nacional Neuroprotective agents in stroke: national opinion

Arquivos de Neuro-Psiquiatria, 2005
Com finalidade de orientar e oferecer subsídios para a conduta diagnóstica e terapêutica em diferentes situações dentro das doenças cerebrovasculares, a Sociedade Brasileira de Doenças Cerebrovasculares (SBDCV) constituiu um comitê composto por ...
Gabriel R. de Freitas, Jorge El Kadum Noujaim, Sérgio R. Haussen, Fábio I. Yamamoto, Edson M. Novak, Rubens J. Gagliardi   +5 more
doaj   +1 more source

Evaluation of the neuroprotective effect of ketoprofen on rats submitted to permanent focal brain ischemia Avaliação do efeito neuroprotetor do cetoprofeno em ratos submetidos à isquemia cerebral focal permanente

Arquivos de Neuro-Psiquiatria, 2007
OBJECTIVE: To study the neurobehavioral, biochemical and histopathological consequences of permanent focal brain ischemia, and the putative neuroprotective action of ketoprofen.
Manoel Nunes da Silva, Benedicto Oscar Colli, Norberto Cysne Coimbra, Joaquim Coutinho Netto   +3 more
doaj   +1 more source

Neurobiological basis of bipolar disorder [PDF]

, 2005
In this article, the authors review relevant aspects related to the neurobiological basis of bipolar disorder. This illness has been associated with complex biochemical and molecular changes in brain circuits linked to neurotransmission and intracellular
Bressan, Rodrigo Affonseca, Frey, Benício, Machado-Vieira, Rodrigo, Soares, Jair C.   +3 more
core   +5 more sources