Results 31 to 40 of about 339,661 (301)

Danshen-Chuanxiong-Honghua Ameliorates Cerebral Impairment and Improves Spatial Cognitive Deficits after Transient Focal Ischemia and Identification of Active Compounds. [PDF]

open access: yes, 2017
Previously, we only apply a traditional Chinese medicine (TCM) Danshen-Chuanxiong-Honghua (DCH) for cardioprotection via anti-inflammation in rats of acute myocardial infarction by occluding coronary artery. Presently, we select not only DCH but also its
Fushun Wang   +9 more
core   +3 more sources

Neuroprotection [PDF]

open access: yesNeurotherapeutics, 2004
Preface.List of Contributors.PART I: NEUROLOGICAL DISORDERS-EPIDEMIOLOGY, CLINICAL OVERVIEW, AND MODEL SYSTEMS.1. Stroke (Andreas Meisel, Konstantin Prass, Tilo Wolf, Ulrich Dirnagl).Abstract.1.1 Introduction.1.2 The Penumbra Concept.1.3 Excitotoxicity.1.4 Oxygen Free Radicals.1.5 Tissue Acidosis.1.6 Peri-infarct Depolarizations.1.7 Inflammation.1.8 ...
  +4 more sources

Friedelin: Structure, Biosynthesis, Extraction, and Its Potential Health Impact

open access: yesMolecules, 2023
Pharmaceutical companies are investigating more source matrices for natural bioactive chemicals. Friedelin (friedelan-3-one) is a pentacyclic triterpene isolated from various plant species from different families as well as mosses and lichen.
Santosh Kumar Singh   +9 more
doaj   +1 more source

Neuroprotection in glaucoma

open access: yesJournal of Ophthalmic and Vision Research, 2016
Glaucoma is a degenerative optic neuropathy characterized by retinal ganglion cell (RGC) loss and visual field defects. It is known that in some glaucoma patients, death of RGCs continues despite intraocular pressure (IOP) reduction. Neuroprotection in the field of glaucoma is defined as any treatment, independent of IOP reduction, which prevents RGC ...
Azadeh Doozandeh, Shahin Yazdani
openaire   +3 more sources

The Intra-nuclear SphK2-S1P Axis Facilitates M1-to-M2 Shift of Microglia via Suppressing HDAC1-Mediated KLF4 Deacetylation

open access: yesFrontiers in Immunology, 2019
Sphingosine 1-phosphate (S1P) is involved in a variety of cellular responses including microglial activation and polarization. However, the impacts of S1P on ischemia-induced microglial activation and polarization remain unclear.
Juan Ji   +14 more
doaj   +1 more source

Insights into the neuroprotective properties of Biochanin-A

open access: yesArchives of Pharmaceutical Sciences Ain Shams University, 2022
The global morbidity and mortality caused by neurological disorders are significant. Neurodegenerative disorders are anticipated to rise as the population ages because they typically manifest in mid-to-late life.
Sarah Hussein   +3 more
doaj   +1 more source

SUR1 Receptor Interaction with Hesperidin and Linarin Predicts Possible Mechanisms of Action of Valeriana officinalis in Parkinson. [PDF]

open access: yes, 2016
Parkinson's disease (PD) is one of the most common neurodegenerative disorders. A theoretical approach of our previous experiments reporting the cytoprotective effects of the Valeriana officinalis compounds extract for PD is suggested.
Andrade, Bruno   +7 more
core   +4 more sources

Inhibition of apoptosis signal-regulating kinase by paeoniflorin attenuates neuroinflammation and ameliorates neuropathic pain

open access: yesJournal of Neuroinflammation, 2019
Background Neuropathic pain is a serious clinical problem that needs to be solved urgently. ASK1 is an upstream protein of p38 and JNK which plays important roles in neuroinflammation during the induction and maintenance of chronic pain.
Danli Zhou   +9 more
doaj   +1 more source

Resveratrol from Dietary Supplement to a Drug Candidate: An Assessment of Potential

open access: yesPharmaceuticals, 2022
Resveratrol (RVT) is a well known phyto-chemical and is widely used in dietary supplements and botanical products. It shows a wide range of pharmacological/beneficial effects.
Shivani Khattar   +11 more
doaj   +1 more source

Argon protects against hypoxic-ischemic brain injury in neonatal rats through activation of Nuclear factor (erythroid-derived 2)-like 2 [PDF]

open access: yes, 2016
Perinatal hypoxic ischaemic encephalopathy (HIE) has a high mortality rate with neuropsychological impairment. This study investigated the neuroprotective effects of argon against neonatal hypoxic-ischaemic brain injury.
Ciechanowicz, S   +6 more
core   +1 more source

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