Results 101 to 110 of about 114,586 (238)

Piper auritum (Kunth) Fungal Endophytes: A Source of Metabolites to Inhibit the Formation of Advanced Glycation End Products

Chemistry &Biodiversity, EarlyView.
Endophytic fungi of P. auritum were evaluated for their ability to produce inhibitors of formation of advanced glycation end products (AGEs). Neopestalotiopsis sp. H2 and Diaporthe sp. H5 extracts were the most active. So, we performed their chemical profiling by untargeted and phenolics‐targeted metabolomic approaches to identify the potential ...
Lory Sthephany Rochín‐Hernández, José Antonio Guerrero‐Analco, Juan Luis Monribot‐Villanueva, Luis Bernardo Flores‐Cotera   +3 more
wiley   +1 more source

Classification Framework and Structure-Activity-Relationship (SAR) of Tetracycline-Structure-Based Drugs

, 2012
By studying the literature about Tetracyclines (TCs), it becomes clearly evident that TCs are very dynamic molecules. In some cases, their structure-activity-relationship (SAR) are known, especially against bacteria, while against other targets, they are
Bortolotto, Carlotti, Chen, Chopra, De Luigi, Doershuk, Duivenvoorden, Dutta, Lambs, McNamara, Nelson, Nelson, Silvia, Stetler-Steveson, Tang, Thong, Wainwright, Yrjanheikki   +17 more
core   +2 more sources

Serotonergic Modulators in Alzheimer's Disease: A Hope in the Hopeless Condition

Chemistry &Biodiversity, EarlyView.
ABSTRACT Alzheimer's disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Najlaa Hamed Almohmadi, Hayder M. Al‐Kuraishy, Ali I. Al‐Gareeb, Ali K. Albuhadily, Morkoss M. Fakhry, Athanasios Alexiou, Marios Papadakis, Gaber El‐Saber Batiha   +7 more
wiley   +1 more source

Identification of a new structural family of SGK1 inhibitors as potential neuroprotective agents. [PDF]

J Enzyme Inhib Med Chem, 2023
Maestro I, Madruga E, Boya P, Martínez A.   +3 more
europepmc   +1 more source

Pharmacokinetic Prediction and Cytotoxicity of New Quercetin Derivatives

Chemistry &Biodiversity, EarlyView.
ABSTRACT Quercetin (QUE) possesses various pharmacological properties; however, its low bioavailability and solubility hinder its beneficial effects. Enzymatic glycosylation has been explored to improve these aspects. In the present study, we used a sucrose phosphorylase variant to catalyze the regioselective transglucosylation of QUE, predicted the ...
Michele Goulart dos Santos, Marie Demonceaux, Lucia Emanueli Schimith, Marine Goux, Claude Solleux, Ana Luiza Muccillo‐Baisch, Bruno Dutra Arbo, Corinne Andre‐Miral, Mariana Appel Hort   +8 more
wiley   +1 more source

Preface: 2022 International Conference on Neuroprotective Agents. [PDF]

Exp Biol Med (Maywood), 2023
Slikker W, Patterson TA, Andrews RJ.
europepmc   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Total Synthesis of Neuroprotective Agents, (+)-Lycibarbarine A and (-)-Lycibarbarine B. [PDF]

J Org Chem, 2023
Ghosh AK, Harper M, Robinson WL.
europepmc   +1 more source

Chemical Characterization, Antioxidant, and Anticholinesterase Activities of Libidibia ferrea (Mart. Ex Tul.) L.P.Queiroz and In Silico Studies with the Acetylcholinesterase Enzyme

Chemistry &Biodiversity, EarlyView.
ABSTRACT Libidibia ferrea is used in many parts of Brazil for a variety of conditions, such as inflammation, respiratory disorders, muscle pain, and gastrointestinal problems. This study evaluated the chemistry and antioxidant and acetylcholinesterase (AChE) inhibitory activities of L. ferrea extracts. Hydroethanolic extracts of leaves (ELLF) and bark (
Lucas Soares Frota, Sara Ingrid Caetano Gomes Barbosa, Camila Costa Feitosa, Francisco Flávio da Silva Lopes, Daniel Pereira de Oliveira, Leonardo Soares Freitas, Adriano Lincoln Albuquerque Mattos, Wildson Max Barbosa da Silva, Hamilton Mitsugu Ishiki, Selene Maia de Morais   +9 more
wiley   +1 more source

Exploring Neuroprotective Agents for Sepsis-Associated Encephalopathy: A Comprehensive Review. [PDF]

Int J Mol Sci, 2023
Krzyzaniak K, Krion R, Szymczyk A, Stepniewska E, Sieminski M.   +4 more
europepmc   +1 more source