Results 81 to 90 of about 87,298 (292)

The Pharmacology of Chlormethiazole: A Potential Neuroprotective Agent? [PDF]

CNS Drug Reviews, 2004
ABSTRACTChlormethiazole is a thiazole derivative with a long history of use as a sedative agent. The mode of action of the drug has been partly worked out and has been established with recognition that its mechanism of action involves potentiation of GABA activity, the major intrinsic inhibitory neurotransmitter.
M J, Wilby, P J, Hutchinson
openaire   +2 more sources

Neuro‐ and Cardioprotective Effects of Blockade of Nitric Oxide Action by Administration of Methylene Blue

, 2007
Methylene blue (MB), generic name methylthioninium (C16H18ClN3 S · 3H2O), is a blue dye synthesized in 1876 by Heinrich Caro for use as a textile dye and used in the laboratory and clinically since the 1890s, with well-known toxicity and pharmacokinetics.
LARS WIKLUND, ADRIANA MICLESCU, Wiklund, Per,, Ronquist, Gunnar,, HARI SHANKER SHARMA, Basu, Samar,, GUNNAR RONQUIST, Miclescu, Adriana,, Wiklund, Lars,, Sharma, Hari Shanker,, PER WIKLUND, SAMAR BASU   +11 more
core   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Some Novel Therapies in Parkinson’s Disease: A Promising Path Forward or Not Yet? A Systematic Review of the Literature

Biomedicines
In light of the unsuccessful traditional therapies for Parkinson’s disease (PD) overmany years, there is an unmet need for the development of novel therapies to alleviate the symptoms of PD retardation or halt the progression of the disease itself.
Anastasia Bougea
doaj   +1 more source

Parkin: a multipurpose neuroprotective agent?

Neuron, 2003
An autosomal recessive juvenile-onset form of Parkinson's disease (AR-JP) is caused by loss-of-function mutations of the parkin gene, which encodes a ubiquitin-protein ligase. Three recent reports demonstrate that parkin can protect neurons from diverse cellular insults, including alpha-synuclein toxicity, proteasomal dysfunction, Pael-R accumulation ...
Feany, Mel B, Pallanck, Leo J
openaire   +2 more sources

Therapeutic Neuroprotective Agents For Amyotrophic Lateral Sclerosis

, 2013
Amyotrophic lateral sclerosis (ALS) is a fatal chronic neurodegenerative disease whose hallmark is proteinaceous, ubiquitinated, cytoplasmic inclusions in motor neurons and surrounding cells.
Zhu, Haining, Wang, Xin, Li, Wei, Pandya, Rachna S., Friedlander, Robert M., Bowser, Robert   +5 more
core   +1 more source

Discovery of neuroprotective agents that inhibit human prolyl hydroxylase PHD2

, 2021
Prolyl hydroxylase (PHD) enzymes play a critical role in the cellular responses to hypoxia through their regulation of the hypoxia inducible factor α (HIF-α) transcription factors.
Weissberger, Daniel, Griffith, Renate, O'Malley, Laura J, Hunter, Luke, Richardson, Nicole L, Jones, Nicole M, Tumber, Anthony, Schofield, Christopher J   +7 more
core   +1 more source

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

Glucagon like peptide-1 receptor agonists as neuroprotective agents for ischemic stroke: a systematic scoping review [PDF]

, 2020
Stroke mortality and morbidity is expected to rise. Despite considerable recent advances within acute ischemic stroke treatment, scope remains for development of widely applicable neuroprotective agents.
Price, Christopher I, Werring, D.J., Maskery, MP, Maskery, Mark P, Maskery, M.P., Price, CI, Watkins, Caroline Leigh, Emsley, H.C.A., Emsley, HCA, Watkins, C.L., Strain, W.D., Werring, David, Jones, SP, Jones, Stephanie, Price, C.I., Watkins, CL, Holscher, C., Strain, WD, Strain, W David, Holscher, Christian, Jones, S.P., Holscher, C, Werring, DJ, Emsley, Hedley C A   +23 more
core   +1 more source

Biomimetic Ru‐Mn Nanozyme with Cascade Catalytic Activity Attenuates Secondary Brain Injury in Intracerebral Hemorrhage

Advanced Science, EarlyView.
Ru–Mn composite nanozymes are engineered to mimic dual‐enzyme cascade catalysis, enabling efficient ROS clearance and neuroinflammation suppression. In collagenase‐ and autologous blood‐induced ICH mouse models, intranasal and intravenous administration reduced hematoma volume, preserved BBB integrity, and improved neurological recovery.
Zhongxin Duan, Peng Li, Yue Wang, Xin Qi, Wanyu Wang, Yongzhong Cheng, Huabin Zhang, Xin Hu, Xiang Gao   +8 more
wiley   +1 more source