Results 51 to 60 of about 88,263 (338)
Marine Drugs, 2019 So far, the Futuna Islands located in the Central Indo-Pacific Ocean have not been inventoried for their diversity in marine sponges and associated chemical diversity. As part of the Tara Pacific expedition, the first chemical investigation of the sponge
Maria Miguel-Gordo +8 more
doaj +1 more source
Chronic Hypertension Aggravates Heat Stress–Induced Cognitive Dysfunction and Brain Pathology
, 2007 Hyperthermia following heat stress results in profound brain edema formation and damage to the central nervous system (CNS). However, whether acute or chronic diseases such as cardiovascular, endocrine, or metabolic ailments further influence the ...
Sharma, Hari S, +3 more
core +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
The neuroprotective effects of hesperidin and diosmin in neurological disorders via targeting various signaling pathways [PDF]
Iranian Journal of Basic Medical SciencesDiosmin and hesperidin, two flavonoid glycosides derived from citrus plants, offer numerous health benefits, whether used alone or in combination. They can mitigate neurodegenerative symptoms and reduce vascular and microbial inflammations, improving ...
Nikoo Abharian +5 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Poststroke cognitive impairment and dementia
Медицинский совет, 2016 Post-stroke cognitive impairment and dementia are one of the major causes of the disability and quality of life deterioration following cerebrovascular accident. In this review we cover current views on the prevalence, mechanisms and risk factors of post-
D. V. Sergeev +2 more
doaj +1 more source
CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang +6 more
wiley +1 more source
Effect of nicotine on the energy metabolism of substantia nigra cells in mptp-induced Parkinson’s disease [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Parkinson’s disease (PD) is a progressive neurodegenerative disorder affecting millions globally, with no current cure despite extensive research efforts.
Nikoloz Zhgenti +6 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2023 BackgroundRecent studies on renin-angiotensin system (RAS) inhibitors have reported a reduced risk of Alzheimer’s disease (AD). Nevertheless, the effect of RAS inhibitor type and blood–brain barrier (BBB) permeability on the risk of AD is still unknown ...
Hyun Woo Lee +7 more
doaj +1 more source