Results 41 to 50 of about 1,639,688 (287)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Potential Role of Olive Oil Phenolic Compounds in the Prevention of Neurodegenerative Diseases

Molecules, 2015
Adherence to the Mediterranean Diet (MD) has been associated with a reduced incidence of neurodegenerative diseases and better cognitive performance.
Jose Rodríguez-Morató, Laura Xicota, Montse Fitó, Magí Farré, Mara Dierssen, Rafael de la Torre   +5 more
doaj   +1 more source

Neuroprotective effect of caffeine in Alzheimer’s disease

, 2023
AIM: This systematic review article aimed to clarify the effect of caffeine on AD and cognition by summarizing all the relevant research done on this topic METHOD: In the present review, we searched the Web of Science core collection and PubMed for ...
Faull, Richard, Kwakowsky, Andrea, M Yelanchezian, Y Mukish, Waldvogel, Henry   +3 more
core  

Comprehensive Assessment of Arterial, Tissue, and Venous Collaterals for Evaluating the Infarct Growth Rate: The Multimodal Collateral Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto, Umberto Pensato, Ilaria Casetta, Giorgio U. Marcello, Angelo Barra, Anna Poggesi, Edoardo Carlesi, Sara Mancini, Andrea Ginestroni, Vittorio Miele, Alessandro Padovani, Andrea Morotti, Enrico Fainardi   +12 more
wiley   +1 more source

Bromotryptamine and Bromotyramine Derivatives from the Tropical Southwestern Pacific Sponge Narrabeena nigra

Marine Drugs, 2019
So far, the Futuna Islands located in the Central Indo-Pacific Ocean have not been inventoried for their diversity in marine sponges and associated chemical diversity. As part of the Tara Pacific expedition, the first chemical investigation of the sponge
Maria Miguel-Gordo, Sandra Gegunde, Kevin Calabro, Laurence K. Jennings, Amparo Alfonso, Grégory Genta-Jouve, Jean Vacelet, Luis M. Botana, Olivier P. Thomas   +8 more
doaj   +1 more source

Improving the Efficacy of Quinolylnitrones for Ischemic Stroke Therapy, QN4 and QN15 as New Neuroprotective Agents after Oxygen–Glucose Deprivation/Reoxygenation-Induced Neuronal Injury

, 2022
In our search for new neuroprotective agents for stroke therapy to improve the pharmacological profile of the compound quinolylnitrone QN23, we have prepared and studied sixteen new, related and easily available quinolylnitrones.
Alonso, José M, Israel Fernández, José Marco-Contelles, Alcázar, Alberto, Alonso Gómez, José Miguel, Fernández, Israel, Alejandro Escobar-Peso, Marco-Contelles, José, Marco Contelles, José, Escobar Peso, Alejandro, José M. Alonso, Alonso, José M., Alberto Alcázar, Escobar-Peso, Alejandro, Fernández López, Israel, Alonso, José   +15 more
core   +1 more source

Risk of Non‐Arteritic Anterior Ischemic Optic Neuropathy in Idiopathic Intracranial Hypertension Patients Treated with GLP‐1 Receptor Agonists

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have demonstrated significant weight‐reducing effects and may offer benefits in idiopathic intracranial hypertension (IIH); however, recent concerns about the risk of non‐arteritic anterior ischemic optic neuropathy (NAION) have emerged.
Faisal A. Al‐Harbi, Mohanad A. Alkuwaiti, Yazeed B. Alaql, Ahmed K. Alsaif, Ahmed A. Alessa, Meshari Ayed Alharbi, Mohammed Alfalah, Saud A. Alnaaim, Sajjad M. AlHaddad, Ahmed Y. Azzam   +9 more
wiley   +1 more source

Synthesis of New 3-Arylcoumarins Bearing N-Benzyl Triazole Moiety: Dual Lipoxygenase and Butyrylcholinesterase Inhibitors With Anti-Amyloid Aggregation and Neuroprotective Properties Against Alzheimer’s Disease

Frontiers in Chemistry, 2022
A novel series of coumarin derivatives linked to the N-benzyl triazole group were synthesized and evaluated against 15-lipoxygenase (15-LOX), and acetyl- and butyrylcholinesterase (AChE and BuChE) to find the most potent derivative against Alzheimer’s ...
Ladan Pourabdi, Tuba Tüylü Küçükkılınç, Fatemeh Khoshtale, Beyza Ayazgök, Hamid Nadri, Farid Farokhi Alashti, Hamid Forootanfar, Tayebeh Akbari, Mohammad Shafiei, Alireza Foroumadi, Alireza Foroumadi, Mohammad Sharifzadeh, Mehdi Shafiee Ardestani, M. Saeed Abaee, Loghman Firoozpour, Mehdi Khoobi, Mehdi Khoobi, Mohammad M. Mojtahedi   +17 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

The neuroprotective effects of hesperidin and diosmin in neurological disorders via targeting various signaling pathways [PDF]

Iranian Journal of Basic Medical Sciences
Diosmin and hesperidin, two flavonoid glycosides derived from citrus plants, offer numerous health benefits, whether used alone or in combination. They can mitigate neurodegenerative symptoms and reduce vascular and microbial inflammations, improving ...
Nikoo Abharian, Noushin Nikray, Afsoon Feizi, Marjan Talebi, Hamed Shafaroodi, Mehrdad Faizi   +5 more
doaj   +1 more source