Results 41 to 50 of about 1,708,461 (194)
Discovery of neuroprotective agents that inhibit human prolyl hydroxylase PHD2 [PDF]
, 2021 Prolyl hydroxylase (PHD) enzymes play a critical role in the cellular responses to hypoxia through their regulation of the hypoxia inducible factor α (HIF-α) transcription factors.
Luke Hunter +7 more
core +1 more source
Are Kynurenines Accomplices or Principal Villains in Dementia? Maintenance of Kynurenine Metabolism
Molecules, 2020 Worldwide, 50 million people suffer from dementia, a group of symptoms affecting cognitive and social functions, progressing severely enough to interfere with daily life.
Masaru Tanaka +2 more
doaj +1 more source
, 2017 To investigate plasma-stable neuroprotective agents, a series of new ligustrazine derivatives were synthesized by conjoining ligustrazine and phenols with ester, ether and amide bonds.
Haimin Lei +8 more
core +1 more source
Fetal Neuroprotective Strategies: Therapeutic Agents and Their Underlying Synaptic Pathways [PDF]
, 2021 Synaptic signaling is integral for proper brain function. During fetal development, exposure to inflammation or mild hypoxic-ischemic insult may lead to synaptic changes and neurological damage that impairs future brain function.
Theresa M. Boyer +2 more
core +1 more source
Potential Role of Olive Oil Phenolic Compounds in the Prevention of Neurodegenerative Diseases
Molecules, 2015 Adherence to the Mediterranean Diet (MD) has been associated with a reduced incidence of neurodegenerative diseases and better cognitive performance.
Jose Rodríguez-Morató +5 more
doaj +1 more source
Marine Drugs, 2019 So far, the Futuna Islands located in the Central Indo-Pacific Ocean have not been inventoried for their diversity in marine sponges and associated chemical diversity. As part of the Tara Pacific expedition, the first chemical investigation of the sponge
Maria Miguel-Gordo +8 more
doaj +1 more source
Thioflavones as novel neuroprotective agents [PDF]
Bioorganic & Medicinal Chemistry, 2016 Oxidative stress is associated with the pathology of neurodegenerative diseases. Identification of small molecules capable of protecting against oxidative stress is therefore of significant importance. In this context, a library of 76 hydroxy flavones, methoxy flavones and their 4-thio analogues has been evaluated for neuroprotection against H2O2 ...
Ravishankar, Divyashree +5 more
openaire +2 more sources
A review of agents patented for their neuroprotective properties.
, 2006 The brain continues to remain an area where little corrective surgery can be performed. Recently, the ability to reverse some brain damage and perhaps prevent further damage has moved closer to hospitals and clinics.
Brimble, Margaret A, Levi, Mark S
core +1 more source
The Use of Neuroprotective Agents in Treating Geographic Atrophy
, 2021 <jats:p>Geographic atrophy (GA) secondary to age-related macular degeneration accounts for close to one-quarter of cases of legal blindness in the USA and the UK.
Scholl, Hendrik +7 more
core +1 more source
The neuroprotective effects of hesperidin and diosmin in neurological disorders via targeting various signaling pathways [PDF]
Iranian Journal of Basic Medical SciencesDiosmin and hesperidin, two flavonoid glycosides derived from citrus plants, offer numerous health benefits, whether used alone or in combination. They can mitigate neurodegenerative symptoms and reduce vascular and microbial inflammations, improving ...
Nikoo Abharian +5 more
doaj +1 more source