Results 21 to 30 of about 88,263 (338)

Neuroprotective agents in the management of glaucoma [PDF]

Eye, 2018
Glaucoma is an optic neuropathy, specifically a neurodegenerative disease characterized by loss of retinal ganglion cells (RGCs) and their axons. The pathogenesis of RGC loss in glaucoma remains incompletely understood and a broad range of possible ...
Giannini C., Morrone L. A., Mancino R., Martucci A., Nucci C., Bagetta G.   +5 more
core   +5 more sources

Nutraceutical Antioxidants as Novel Neuroprotective Agents [PDF]

Molecules, 2010
A variety of antioxidant compounds derived from natural products (nutraceuticals) have demonstrated neuroprotective activity in either in vitro or in vivo models of neuronal cell death or neurodegeneration, respectively.
Daniel A. Linseman, Natalie A. Kelsey, Heather M. Wilkins   +2 more
doaj   +3 more sources

Mining and evaluation of security alert signals of neuroprotective agents based on the Jinan adverse event reporting system database: a retrospective study [PDF]

Frontiers in Pharmacology
BackgroundPharmacologic agents with proposed neuroprotective properties are increasingly investigated; however, limited regulation and heterogeneous evidence raise concerns about their safety profiles. To establish a foundation for its safe clinical use,
Yu-yao Guan, Jing Yang, Ying-mei Qi, Chao Song, Lei Zheng   +4 more
doaj   +2 more sources

Impact of neuroprotective agents on mortality and neurological outcomes in traumatic brain injury patients from road traffic accidents

Asian Journal of Medical Sciences
Background: Traumatic brain injuries (TBIs) are a leading cause of morbidity and mortality worldwide, particularly those resulting from road traffic accidents. Secondary brain injury mechanisms, such as inflammation and oxidative stress, play significant
Shivam Sharma , Dinesh Shukla , Sanjay Chaube , Naseem Akram   +3 more
doaj   +3 more sources

Thioflavones as novel neuroprotective agents [PDF]

Bioorganic & Medicinal Chemistry, 2016
Oxidative stress is associated with the pathology of neurodegenerative diseases. Identification of small molecules capable of protecting against oxidative stress is therefore of significant importance.
Osborn, Helen M. I., Spencer, Jeremy P. E., Greco, Francesca, Hogan, Stephanie M, Osborn, Helen M I, Ravishankar, Divyashree, Hogan, Stephanie M., Corona, Giulia   +7 more
core   +4 more sources

Ginseng polysaccharides: A potential neuroprotective agent

Journal of Ginseng Research, 2020
The treatments of nervous system diseases (NSDs) have long been difficult issues for researchers because of their complexity of pathogenesis. With the advent of aging society, searching for effective treatments of NSDs has become a hot topic. Ginseng polysaccharides (GP), as the main biologically active substance in ginseng, has various biological ...
Na Wang, Xianlei Wang, Mengjiao He, Wenxiu Zheng, Dongmei Qi, Yongqing Zhang, Chunchao Han   +6 more
openalex   +4 more sources

Carboxyfullerenes as neuroprotective agents [PDF]

Proceedings of the National Academy of Sciences, 1997
Two regioisomers with C 3 or D 3 symmetry of water-soluble carboxylic acid C 60 derivatives, containing three malonic acid groups per molecule, were synthesized and found to be equipotent free radical scavengers in solution as assessed by EPR ...
Dugan, Laura L., Turetsky, Dorothy M., Du, Cheng, Lobner, Doug, Wheeler, Mark, Almli, C. Robert, Shen, Clifton K. F., Luh, Tien-Yau, Choi, Dennis W., Lin, Tien-Sung   +9 more
openaire   +2 more sources

Cytotoxicity Profiles and Neuroprotective Properties of the Novel Ifenprodil Analogues as Sigma Ligands

Molecules, 2023
Neurodegeneration is a slow and progressive loss of neuronal cells or their function in specific regions of the brain or in the peripheral system.
Daniele Zampieri, Antonella Calabretti, Maurizio Romano, Sara Fortuna, Simona Collina, Emanuele Amata, Maria Dichiara, Agostino Marrazzo, Maria Grazia Mamolo   +8 more
doaj   +1 more source

Fetal Neuroprotective Strategies: Therapeutic Agents and Their Underlying Synaptic Pathways [PDF]

, 2021
Synaptic signaling is integral for proper brain function. During fetal development, exposure to inflammation or mild hypoxic-ischemic insult may lead to synaptic changes and neurological damage that impairs future brain function.
Theresa M. Boyer, Nada A. Elsayed, Irina Burd   +2 more
core   +1 more source

Putative neuroprotective agents in neuropsychiatric disorders [PDF]

, 2013
In many individuals with major neuropsychiatric disorders including depression, bipolar disorder and schizophrenia, their disease characteristics are consistent with a neuroprogressive illness.
Anderson, G, Berk, M, Moylan, S, Dodd, S, Maes, M, Dean, OM   +5 more
core   +1 more source