Neuroprotective agents in the management of glaucoma [PDF]
Eye, 2018 Glaucoma is an optic neuropathy, specifically a neurodegenerative disease characterized by loss of retinal ganglion cells (RGCs) and their axons. The pathogenesis of RGC loss in glaucoma remains incompletely understood and a broad range of possible mechanisms have been implicated.
Nucci C. +5 more
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Comparative efficacy of neuroprotective agents for improving neurological function and prognosis in acute ischemic stroke: a network meta-analysis [PDF]
Frontiers in NeuroscienceBackgroundIschemic stroke is the second leading cause of death and the third leading cause of combined disability and mortality globally. While reperfusion therapies play a critical role in the management of acute ischemic stroke (AIS), their ...
Yuchen Wang +6 more
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Thioflavones as novel neuroprotective agents [PDF]
Bioorganic & Medicinal Chemistry, 2016 Oxidative stress is associated with the pathology of neurodegenerative diseases. Identification of small molecules capable of protecting against oxidative stress is therefore of significant importance. In this context, a library of 76 hydroxy flavones, methoxy flavones and their 4-thio analogues has been evaluated for neuroprotection against H2O2 ...
Ravishankar, Divyashree +5 more
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Impact of neuroprotective agents on mortality and neurological outcomes in traumatic brain injury patients from road traffic accidents [PDF]
Asian Journal of Medical SciencesBackground: Traumatic brain injuries (TBIs) are a leading cause of morbidity and mortality worldwide, particularly those resulting from road traffic accidents. Secondary brain injury mechanisms, such as inflammation and oxidative stress, play significant
Shivam Sharma +3 more
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2024 international conference on neuroprotective agents conference proceedings [PDF]
Experimental Biology and MedicineWilliam Slikker +3 more
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Therapeutic potential of agmatine in the experimental autoimmune encephalomyelitis [PDF]
Vojnosanitetski Pregled, 2021 Background/Aim. Experimental autoimmune encephalomyelitis (EAE) is a model of multiple sclerosis (MS), in which we investigated the neuroprotective effect of agmatine (AGM), known as a primary amine produced via the decarboxylation of L-arginine. Methods.
Stevanović Ivana +4 more
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Exploration of Neuroprotective Therapy, 2023 Acute ischemic stroke (AIS) is the leading cause of disability and one of the top causes of mortality worldwide. The current standard of care is reperfusion therapy including intravenous thrombolysis (IVT) and thrombectomy. However, these treatments have
Grace YY Chia +5 more
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The Antioxidative Effects of Picein and Its Neuroprotective Potential: A Review of the Literature
Molecules, 2022 Neurodegenerative diseases (NDDs) are the main cause of dementia in the elderly, having no cure to date, as the currently available therapies focus on symptom remission.
Leila Elyasi +3 more
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Graph theoretical network analysis, in silico exploration, and validation of bioactive compounds from Cynodon dactylon as potential neuroprotective agents against α-synuclein [PDF]
BioImpacts, 2022 Introduction: Parkinson's disease (PD) is a chronic, devastating neurodegenerative disorder marked by the death of dopaminergic neurons in the midbrain's substantia nigra pars compacta (Snpc). In alpha-synuclein (α-Syn) self-aggregation, the existence of
Raja Rajeswari Rajeshkumar +9 more
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Mechanisms and Potential Benefits of Neuroprotective Agents in Neurological Health. [PDF]
NutrientsThe brain contains many interconnected and complex cellular and molecular mechanisms. Injury to the brain causes permanent dysfunctions in these mechanisms.
Pekdemir B +6 more
europepmc +2 more sources