Results 31 to 40 of about 88,263 (338)

Protective activity of aromatic amines and imines against oxidative nerve cell death [PDF]

, 2001
Oxidative stress is a widespread phenomenon in the pathology of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
Skutella, T., Behl, Christian, Beyer, Klaus, Moosmann, Bernd, Behl, C., Moosmann, B., Beyer, K., Skutella, Thomas   +7 more
core   +1 more source

Neuroprotective approach in acute ischemic stroke: A systematic review of clinical and experimental studies

Brain Circulation, 2022
Ischemic stroke is a disease with worldwide economic and social negative effects. It is a serious disease with high disability and mortality. Ionic imbalance, excitotoxicity, oxidative stress, and inflammation are induced during and after ischemic stroke.
Fettah Eren, Sueda Ecem Yilmaz
doaj   +1 more source

Erythropoietin: a multimodal neuroprotective agent [PDF]

Experimental & Translational Stroke Medicine, 2009
The tissue protective functions of the hematopoietic growth factor erythropoietin (EPO) are independent of its action on erythropoiesis. EPO and its receptors (EPOR) are expressed in multiple brain cells during brain development and upregulated in the adult brain after injury.
Byts, Nadiya, Sirén, Anna-Leena
openaire   +2 more sources

The Use of Neuroprotective Agents in Treating Geographic Atrophy

, 2021
<jats:p>Geographic atrophy (GA) secondary to age-related macular degeneration accounts for close to one-quarter of cases of legal blindness in the USA and the UK.
Scholl, Hendrik, Chong, Victor, Giani, Andrea, Boyer, David   +3 more
core   +1 more source

Neuroprotective Effect of Apigenin on Pentylenetetrazole-Induced Convulsions in Chicks [PDF]

Research Journal of Pharmacognosy
Background and objectives: Epileptic seizures involve excessive neuronal activity, oxidative stress, and neurotransmitter imbalances, while natural flavonoids are known for their neuroprotective properties.
Karwan Idrees Jarjees*, Jian Salam Hasan, Suleiman Dawood Suleiman, Ramadhan Ado Khanamir   +3 more
doaj   +1 more source

In Vivo Assessment of the Ameliorative Impact of Some Medicinal Plant Extracts on Lipopolysaccharide-Induced Multiple Sclerosis in Wistar Rats

Molecules, 2022
Multiple sclerosis is a chronic autoimmune disorder that leads to the demyelination of nerve fibers, which is the major cause of non-traumatic disability all around the world. Herbal plants Nepeta hindustana L., Vitex negundo L., and Argemone albiflora L.
Rabia Rasool, Inam Ullah, Samiah Shahid, Bismillah Mubeen, Syed Sarim Imam, Sultan Alshehri, Mohammed M. Ghoneim, Sami I. Alzarea, Bibi Nazia Murtaza, Muhammad Shahid Nadeem, Imran Kazmi   +10 more
doaj   +1 more source

Ginsenosides: A Potential Neuroprotective Agent [PDF]

BioMed Research International, 2018
Ginseng is a traditional Chinese medicine with a wide range of pharmacological activities. Ginsenosides are the major constituents of ginseng. Ginsenosides have the unique biological activity and medicinal value, such as antitumor, anti-inflammatory, antioxidation, and inhibition of cell apoptosis.
Mengmeng Zheng, Yizhou Xin, Yujuan Li, Fangxue Xu, Xiaozhi Xi, Hong Guo, Xiaowei Cui, Hui Cao, Xi Zhang, Chunchao Han   +9 more
openaire   +2 more sources

Synthesis of New 3-Arylcoumarins Bearing N-Benzyl Triazole Moiety: Dual Lipoxygenase and Butyrylcholinesterase Inhibitors With Anti-Amyloid Aggregation and Neuroprotective Properties Against Alzheimer’s Disease

Frontiers in Chemistry, 2022
A novel series of coumarin derivatives linked to the N-benzyl triazole group were synthesized and evaluated against 15-lipoxygenase (15-LOX), and acetyl- and butyrylcholinesterase (AChE and BuChE) to find the most potent derivative against Alzheimer’s ...
Ladan Pourabdi, Tuba Tüylü Küçükkılınç, Fatemeh Khoshtale, Beyza Ayazgök, Hamid Nadri, Farid Farokhi Alashti, Hamid Forootanfar, Tayebeh Akbari, Mohammad Shafiei, Alireza Foroumadi, Alireza Foroumadi, Mohammad Sharifzadeh, Mehdi Shafiee Ardestani, M. Saeed Abaee, Loghman Firoozpour, Mehdi Khoobi, Mehdi Khoobi, Mohammad M. Mojtahedi   +17 more
doaj   +1 more source

Improving the Efficacy of Quinolylnitrones for Ischemic Stroke Therapy, QN4 and QN15 as New Neuroprotective Agents after Oxygen–Glucose Deprivation/Reoxygenation-Induced Neuronal Injury

, 2022
In our search for new neuroprotective agents for stroke therapy to improve the pharmacological profile of the compound quinolylnitrone QN23, we have prepared and studied sixteen new, related and easily available quinolylnitrones.
Alonso, José M, Israel Fernández, José Marco-Contelles, Alcázar, Alberto, Alonso Gómez, José Miguel, Fernández, Israel, Alejandro Escobar-Peso, Marco-Contelles, José, Marco Contelles, José, Escobar Peso, Alejandro, José M. Alonso, Alonso, José M., Alberto Alcázar, Escobar-Peso, Alejandro, Fernández López, Israel, Alonso, José   +15 more
core   +1 more source

Molecular Hydrogen as a Neuroprotective Agent [PDF]

Current Neuropharmacology, 2017
Oxidative stress and neuroinflammation cause many neurological disorders. Recently, it has been reported that molecular hydrogen (H2) functions as an antioxidant and anti-inflammatory agent. The routes of H2 administration in animal model and human clinical studies are roughly classified into three types, inhalation of H2 gas, drinking H2-dissolved ...
Iketani, Masumi, Ohsawa, Ikuroh
openaire   +2 more sources