Results 61 to 70 of about 3,331,814 (239)

Applications of Liposomal Drug Delivery Systems to Develop Neuroprotective Agents for the Treatment of Ischemic Stroke.

Biological and Pharmaceutical Bulletin, 2019
Ischemic stroke is one of the leading causes of severe disability and death. In clinical settings, tissue plasminogen activator (t-PA) for thrombolytic therapy is the only globally approved drug for the treatment of ischemic stroke.
T. Fukuta, Takayuki Ishii, T. Asai, N. Oku   +3 more
semanticscholar   +1 more source

Melatonin Pharmacokinetics Following Oral Administration in Preterm Neonates

Molecules, 2017
Melatonin possesses potential efficacy in perinatal brain injuries, and has been proposed as adjunctive pharmacological therapy in combination with hypothermia in the clinical setting.
Silvia Carloni, Fabrizio Proietti, Marco Rocchi, Mariangela Longini, Lucia Marseglia, Gabriella D’Angelo, Walter Balduini, Eloisa Gitto, Giuseppe Buonocore   +8 more
doaj   +1 more source

Piracetam in Postconcussion Syndrome: preliminary results of a randomised study using SPECT [PDF]

The Indian Journal of Neurotrauma, 2007
Aim of this study was to study the changes in regional cerebral perfusion following administration of the drug piracetam using single photon emission computed tomography (SPECT) in patients with postconcussion syndrome (PCS).
Deepak Agrawal, NK Gowda
doaj  

The use of Thiocetam in the complex therapy of combat-related brain contusion

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2023
Each patient presents a unique set of characteristics and challenges when it comes to acute cerebral ischemia resulting from craniocerebral injury.
I. F. Bielenichev, K. Yu. Nerianov, V. I. Chernii, D. A. Sereda, L. I. Kucherenko, N. V. Derevianko, К. І. Kandybei   +6 more
doaj   +1 more source

Sulfur-containing secondary metabolites as neuroprotective agents.

Current Medicinal Chemistry, 2018
Sulfur containing secondary metabolites are a relatively small group of substances of plant origin. The present review is focused on their neuroprotective properties. The results obtained in a series of in vitro and in vivo studies are reported.
A. Venditti, A. Bianco
semanticscholar   +1 more source

Neuroprotective Strategies for Ischemic Stroke—Future Perspectives

International Journal of Molecular Sciences, 2023
Ischemic stroke is the main cause of death and the most common cause of acquired physical disability worldwide. Recent demographic changes increase the relevance of stroke and its sequelae.
Matteo Haupt, S. Gerner, M. Bähr, T. Doeppner   +3 more
semanticscholar   +1 more source

Decoupling Behavioral Domains via Kynurenic Acid Analog Optimization: Implications for Schizophrenia and Parkinson’s Disease Therapeutics

Cells
Kynurenic acid (KYNA), a putative neuroprotective agent, modulates glutamatergic pathways in schizophrenia and Parkinson’s disease but is limited by acute motor activity impairments (e.g., ataxia).
Diána Martos, Bálint Lőrinczi, István Szatmári, László Vécsei, Masaru Tanaka   +4 more
doaj   +1 more source

Through scaffold modification to 3,5-diaryl-4,5-dihydroisoxazoles: new potent and selective inhibitors of monoamine oxidase B

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
3,5-Diaryl-4,5-dihydroisoxazoles were synthesized and evaluated as monoamine oxidase (MAO) enzyme inhibitors and iron chelators. All compounds exhibited selective inhibitory activity towards the B isoform of MAO in the nanomolar concentration range.
Rita Meleddu, Simona Distinto, Roberto Cirilli, Stefano Alcaro, Matilde Yanez, Maria Luisa Sanna, Angela Corona, Claudia Melis, Giulia Bianco, Peter Matyus, Filippo Cottiglia, Elias Maccioni   +11 more
doaj   +1 more source

Effect of Oral Administration of S-allyl Cysteine (the Active Ingredient in the Aged Garlic Extract) on the Symptoms of Multiple Sclerosis in the Experimental Model

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2020
Background and Objectives: Autoimmune inflammation of the central nervous system followed by myelin destruction,  oxidative stress, and reduced neuroprotective factors play key roles in the pathogenesis of multiple sclerosis (MS). S-allyl cysteine (SAC),
Hossein Zeinali, Tourandokht Baluchnejadmojarad, Mehrdad Roghani   +2 more
doaj  

Zinc ionophores as neuroprotective agents [PDF]

Journal of Neurochemistry, 2003
Zinc ionophores, molecules that carry zinc ions across the cell membrane, can decrease apoptosis in animals subjected to experimental heart attack, brain injury, neurodegeneration, and epilepsy. Here we show that zinc ionophores at low μg/kg BW doses have neuroprotective effects in three different stroke models in rodents: focal ischemia models (middle
Natalia V. Gulyaeva, Mikhail Stepanichev, Mikhail V. Onufriev, Henry Fliss, N. A. Lazareva   +4 more
openaire   +2 more sources