Results 51 to 60 of about 1,522,567 (255)

Employment Trajectories of Patients With Systemic Lupus Erythematosus and Factors Driving Transitions Between States

Arthritis Care &Research, EarlyView.
Objective Systemic lupus erythematosus (SLE) significantly impacts employment capacity. This study aimed to investigate the impact of burden of disease activity, damage, and treatment on employment outcomes and transitions in patients with SLE. Methods Using data from a single center, we analyzed employment transitions, adjusted mean disease activity ...
Javier Mencia‐Ledo, Zahi Touma, Laura Whittall Garcia, Dafna D. Gladman, Behdin Nowrouzi‐Kia   +4 more
wiley   +1 more source

Health-related quality of life, neuropsychiatric symptoms and structural brain changes in clinically isolated syndrome.

PLoS ONE, 2018
BackgroundNeuropsychiatric symptoms and reduced health-related quality of life (HRQoL) are frequent in multiple sclerosis, where are associated with structural brain changes, but have been less studied in clinically isolated syndrome (CIS).ObjectiveTo ...
Eva Hyncicova, Adam Kalina, Martin Vyhnalek, Tomas Nikolai, Lukas Martinkovic, Jiri Lisy, Jakub Hort, Eva Meluzinova, Jan Laczó   +8 more
doaj   +1 more source

Forest plot of Neuropsychiatric symptoms.

, 2019
Forest plot of Neuropsychiatric symptoms.
Fengling Dai (7832822), Xiaoqin Liu (296429), Lin He (102807), Kejimu Sunzi (7832819), Yanfen Wang (104864), Mei Ju (7832825), Cheng Lei (6883532), Baolu Zhang (5516504)   +7 more
core   +1 more source

A Scoping Review and Meta‐Analysis of Proportions of Central Nervous System Manifestations Reported in Patients with Sjögren's Disease

Arthritis Care &Research, Accepted Article.
Objective The objective of this scoping review was to synthesize evidence on the proportion of individuals living with Sjögren's disease who experience central nervous system (CNS) manifestations. Methods We searched MEDLINE (via PubMed) and Embase from 1980 through January 29, 2026, and the ECRI Guidelines Trust from 2020 through January 29, 2026 ...
Arun Varadhachary, Ghaith Noaiseh, Julie Frantsve‐Hawley, Frederick B. Vivino, Jennifer A. McCombe, Shamik Bhattacharyya, E. Sherwood Brown, Andrew R. Carey, Robert Fox, Thomas Grader‐Beck, Janet E. Lewis, Stephen Maitz, Steven Mandel, Astrid Rasmussen, George Sarka, R. Hal Scofield, Daniel J. Wallace, Rochelle Zak, Kristie Cox, Katherine M. Hammitt, Steven Carsons, Nancy Carteron   +21 more
wiley   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Neuropsychiatric symptoms and subsyndromes in patients with different stages of dementia in primary care follow-up (NeDEM project): a cross-sectional study

BMC Geriatrics, 2022
Background The objective was to describe the prevalence and intensity of neuropsychiatric symptoms (NPSs) isolated and grouped into subsyndromes in patients with dementia in primary care (PC) to analyse their distribution based on stages of dementia and ...
Victoria García-Martín, M. Canto de Hoyos-Alonso, Gloria Ariza-Cardiel, Rosalía Delgado-Puebla, Paula García-Domingo, Erika Hernández-Melo, Javier López de Haro-de Torres, Isabel del Cura-González   +7 more
doaj   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Neuropsychiatric symptoms and celiac disease

Neuropsychiatric Disease and Treatment, 2014
Małgorzata Urban-Kowalczyk,1 Janusz Śmigielski,2 Agnieszka Gmitrowicz3 1Affective and Psychotic Disorders Department, Medical University of Łódź, Łódź, Poland; 2Department of Geriatric Medicine Medical University of Łódź ...
Urban-Kowalczyk M, Śmigielski J, Gmitrowicz A   +2 more
doaj  

Impact of Neuropsychiatric Symptoms on the Quality of Life of Subjects with Parkinson’s Disease

Journal of Parkinson’s Disease
Background: Neuropsychiatric symptoms in Parkinson’s disease (PD) are frequent. Impact of neuropsychiatric symptoms on quality of life has recently become a relevant topic of research due to its potential to develop targeted therapies to improve quality ...
Alonso Alvarado-Bolaños, Amin Cervantes-Arriaga, Mayela Rodríguez-Violante, Rodrigo Llorens-Arenas, Humberto Calderón-Fajardo, Roxanna Millán-Cepeda, Roberto Leal-Ortega, Ingrid Estrada-Bellmann, Carlos Zuñiga-Ramírez   +8 more
doaj   +1 more source

Neuropsychiatric symptoms and their impact on quality of life in multiple system atrophy

Cogent Psychology, 2016
Background: Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder characterized by severe dysautonomia and atypical Parkinsonism or cerebellar dysfunction.
R. Ceponiene, S.D. Edland, T.N. Reid, A. Al Rizaiza, I. Litvan   +4 more
doaj   +1 more source