Results 61 to 70 of about 1,522,567 (255)

Persisting neuropsychiatric symptoms, Alzheimer’s disease, and cerebrospinal fluid cortisol and dehydroepiandrosterone sulfate

Alzheimer’s Research & Therapy, 2022
Introduction Neuropsychiatric symptoms are important treatment targets in the management of dementia and can be present at very early clinical stages of neurodegenerative diseases.
Sami Ouanes, Miriam Rabl, Christopher Clark, Clemens Kirschbaum, Julius Popp   +4 more
doaj   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Beyond Neuropsychiatric Diagnotics: Symptoms not Disorders

, 2009
Beyond Neuropsychiatric Diagnosis: Symptoms Not Disorders” was fertilized, confined, nourished and delivered on the 17th October (2007) with a particular type of neurodevelopmental maturity on the 21st October 2007: in gestation, an elephant, in life ...
Archer, Trevor,, Kostrzewa, RM, Palomo, T, Beninger, R.J.   +3 more
core  

Neuropsychiatric symptoms in dementia: long-term course and neuropathology [PDF]

, 2019
Aim: Neuropsychiatric symptoms (NPS) such as anxiety, apathy, and psychosis are important manifestations of dementia that have a major impact on the patient’s quality of life, carer burden, and risk of institutionalisation.
Vik-Mo, Audun Osland
core   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Neuropsychiatric symptoms in patients with aortic aneurysms [PDF]

, 2011
Neuropsychiatric symptoms in patients with aortic ...
F Quirk (13320951), J Golledge (13320918), BT Baune (7723655), SJ Unwin (14540930)   +3 more
core   +3 more sources

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Sundown syndrome in patients with Alzheimer’s disease dementia

Dementia & Neuropsychologia, 2019
The sundown syndrome is a complex neurobehavioral disorder in patients with dementia associated with high financial cost and significant caregiver burden.
Cristiani Sartorio Menegardo, Fernanda Alencar Friggi, Julia Baldon Scardini, Tais Souza Rossi, Thais dos Santos Vieira, Alessandra Tieppo, Renato Lirio Morelato   +6 more
doaj   +1 more source

Neuropsychiatric symptoms in untreated Parkinson’s disease

, 2017
Szabolcs Szatmari,1–3 Ben Min-Woo Illigens,4 Timo Siepmann,5,6 Alexandra Pinter,5,7 Annamaria Takats,8 Daniel Bereczki8 1Department of Neurology, Sibiu County Emergency Hospital, Sibiu, 22nd Department of Neurology, Targu Mures Emergency Clinical ...
Takats A, Illigens BM, Szatmari S, Siepmann T, Bereczki D, Pinter A   +5 more
core  

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source