Impairing one sensory modality enhances another by reconfiguring peptidergic signalling in Caenorhabditis elegans [PDF]
eLife, 2022 Animals that lose one sensory modality often show augmented responses to other sensory inputs. The mechanisms underpinning this cross-modal plasticity are poorly understood. We probe such mechanisms by performing a forward genetic screen for mutants with
Giulio Valperga, Mario de Bono
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E. coli infection disrupts the epithelial barrier and activates intrinsic neurosecretory reflexes in the pig colon [PDF]
Frontiers in Physiology, 2023 This study aims to assess the barrier integrity and possible activation of enteric neural pathways associated with secretion and motility in the pig colon induced by an enterotoxigenic Escherichia coli (ETEC) challenge.
Sara Traserra +5 more
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V-ATPase modulates exocytosis in neuroendocrine cells through the activation of the ARNO-Arf6-PLD pathway and the synthesis of phosphatidic acid [PDF]
Frontiers in Molecular Biosciences, 2023 Although there is mounting evidence indicating that lipids serve crucial functions in cells and are implicated in a growing number of human diseases, their precise roles remain largely unknown.
Qili Wang +8 more
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Designing New Natural‐Mimetic Phosphatidic Acid: A Versatile and Innovative Synthetic Strategy for Glycerophospholipid Research [PDF]
Angewandte Chemie, Volume 137, Issue 36, September 1, 2025.We report the role of the fatty acyl chains in biological activities of phosphatidic acids (PA). Several PA probes having two different fatty acyl chains were synthesized through a multi‐steps synthesis and bearing various fluorophores or photo‐cross‐linkers (PCL).
Antoine Schlichter +29 more
wiley +3 more sources
Aluminum Exposure Impairs Electrochemically Measured Vesicular Storage and Exocytosis via Iron Homeostasis Dysregulation [PDF]
Angewandte Chemie, Volume 137, Issue 48, November 24, 2025.Al3+ competes with Fe3+ for transferrin (Tf) binding and enters cells via transferrin receptor (TfR)‐mediated endocytosis, disrupting cellular iron homeostasis. Intracellular vesicle impact electrochemical cytometry (IVIEC) and single‐cell amperometry (SCA), which record the oxidation of dopamine, reveal increased neurotransmitter storage and ...
Shi‐Hua Chen +3 more
wiley +3 more sources
The Role of Vti1a in Biological Functions and Its Possible Role in Nervous System Disorders [PDF]
Frontiers in Molecular Neuroscience, 2022 Vesicle transport through interaction with t-SNAREs 1A (Vti1a), a member of the N-ethylmaleimide-sensitive factor attachment protein receptor protein family, is involved in cell signaling as a vesicular protein and mediates vesicle trafficking.
Fajuan Tang +11 more
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Presynaptic Acetylcholine Receptors Modulate the Time Course of Action Potential-Evoked Acetylcholine Quanta Secretion at Neuromuscular Junctions [PDF]
Biomedicines, 2022 For effective transmission of excitation in neuromuscular junctions, the postsynaptic response amplitude must exceed a critical level of depolarization to trigger action potential spreading along the muscle-fiber membrane.
Ellya A. Bukharaeva +3 more
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The Role of Nicotinic Receptors on Ca2+ Signaling in Bovine Chromaffin Cells [PDF]
Current Issues in Molecular BiologyChromaffin cells have been used as a physiological model to understand neurosecretion in mammals for many years. Nicotinic receptors located in the cells’ membrane are stimulated by acetylcholine, and they participate in the exocytosis of chromaffin ...
Amparo Gil +3 more
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Brevenal inhibits pacific ciguatoxin-1B-induced neurosecretion from bovine chromaffin cells.
PLoS ONE, 2008 Ciguatoxins and brevetoxins are neurotoxic cyclic polyether compounds produced by dinoflagellates, which are responsible for ciguatera and neurotoxic shellfish poisoning (NSP) respectively. Recently, brevenal, a natural compound was found to specifically
César Mattei +9 more
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Substance P immunoreactivity exhibits frequent colocalization with kisspeptin and neurokinin B in the human infundibular region. [PDF]
PLoS ONE, 2013 Neurons synthesizing neurokinin B (NKB) and kisspeptin (KP) in the hypothalamic arcuate nucleus represent important upstream regulators of pulsatile gonadotropin-releasing hormone (GnRH) neurosecretion.
Erik Hrabovszky +8 more
doaj +3 more sources