Results 41 to 50 of about 5,802 (234)
eLife, 2020 Eukaryotic 5’−3’ mRNA decay plays important roles during development and in response to stress, regulating gene expression post-transcriptionally. In Caenorhabditis elegans, deficiency of DCAP-1/DCP1, the essential co-factor of the major cytoplasmic mRNA
Fivos Borbolis +10 more
doaj +1 more source
Forgetting in C. elegans Is Accelerated by Neuronal Communication via the TIR-1/JNK-1 Pathway
Cell Reports, 2013 The control of memory retention is important for proper responses to constantly changing environments, but the regulatory mechanisms underlying forgetting have not been fully elucidated. Our genetic analyses in C. elegans revealed that mutants of the TIR-
Akitoshi Inoue +7 more
doaj +1 more source
MECHANISMS OF DISEASE Acute Oxygen-Sensing Mechanisms [PDF]
, 2005 JOSEPH PRIESTLEY, ONE OF THE THREE SCIENTISTS CREDITED WITH THE discovery of oxygen, described the death of mice that were deprived of oxygen. However, he was also well aware of the toxicity of too much oxygen, stating, “For as a candle burns much faster
Buckler, Keith J. +3 more
core
Rapid Nongenomic Effects of Oestradiol on Gonadotrophin‐Releasing Hormone Neurones [PDF]
, 2012 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/89550/1/j.1365-2826.2011.02135.x ...
Abe +45 more
core +1 more source
Scientific Reports, 2023 The study aimed to reveal physical exercise conditions and catecholamine response-dependent differences while an individual experiences a flow state (FS) following noncompetitive and competitive running drills.
István Karsai +8 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2020 Autophagy and endolysosomal trafficking are crucial in neuronal development, function and survival. These processes ensure efficient removal of misfolded aggregation-prone proteins and damaged organelles, such as dysfunctional mitochondria, thus allowing
Silvia Giovedì +9 more
doaj +1 more source
Loss of the transcriptional repressor PAG-3/Gfi-1 results in enhanced neurosecretion that is dependent on the dense-core vesicle membrane protein IDA-1/IA-2. [PDF]
PLoS Genetics, 2009 It is generally accepted that neuroendocrine cells regulate dense core vesicle (DCV) biogenesis and cargo packaging in response to secretory demands, although the molecular mechanisms of this process are poorly understood.
Tao Cai +6 more
doaj +1 more source
Enteric neuropathy and the vagus nerve: Therapeutic implications
Neurogastroenterology &Motility, Volume 37, Issue 8, August 2025.Abstract Enteric neuropathies are characterized by abnormalities of gut innervation, which includes the enteric nervous system, inducing severe gut dysmotility among other dysfunctions. Most of the gastrointestinal tract is innervated by the vagus nerve, the efferent branches of which have close interconnections with the enteric nervous system and ...
Bruno Bonaz
wiley +1 more source
In vivo analysis of conserved C. elegans tomosyn domains. [PDF]
PLoS ONE, 2011 Neurosecretion is critically dependent on the assembly of a macromolecular complex between the SNARE proteins syntaxin, SNAP-25 and synaptobrevin. Evidence indicates that the binding of tomosyn to syntaxin and SNAP-25 interferes with this assembly ...
Anna O Burdina +4 more
doaj +1 more source
Journal of Extracellular Vesicles, Volume 14, Issue 6, June 2025.ABSTRACT Stroke is a leading cause of death and disability. The therapeutic potential of mesenchymal stem cell‐derived extracellular vesicles (MSC‐EVs) has shown considerable promise in rodent models of stroke. However, the therapeutic efficacy and safety of clinical‐scale MSC‐EVs for ischemic stroke are not well elucidated, especially in non‐human ...
Eun Hee Kim +7 more
wiley +1 more source