Results 51 to 60 of about 12,549 (250)

Metabolic profiling of human plasma and urine in chronic kidney disease by hydrophilic interaction liquid chromatography coupled with time-of-flight mass spectrometry : a pilot study [PDF]

, 2017
A typical characteristic of chronic kidney disease (CKD) is the progressive loss in renal function over a period of months or years with the concomitant accumulation of uremic retention solutes in the body.
Boelaert, Jente, Glorieux, Griet, Lynen, Frederic, Neirynck, Nathalie, Schepers, Eva, Vanholder, Raymond   +5 more
core   +1 more source

Women with epilepsy: Evidence‐based counseling across the lifespan

Epilepsia, EarlyView.
Abstract Women with epilepsy (WWE) encounter distinct and evolving challenges across the lifespan that require clinical management extending beyond seizure control alone. Although awareness of sex‐specific aspects of epilepsy has increased, important gaps remain in their integration into routine care.
Barbara Tettenborn, Georgia Ramantani, Dominique Flügel, Verena Gaus, Susanne Schubert‐Bast, Elisabeth Sellitto, Jennifer Bausch, Bettina Schmitz   +7 more
wiley   +1 more source

Endogenous neurosteroids influence synaptic GABA_A receptors during post-natal development [PDF]

, 2017
GABA plays a key role in both embryonic and neonatal brain development. For example, during early neonatal nervous system maturation, synaptic transmission, mediated by GABA A receptors (GABA ARs), undergoes a temporally specific form of synaptic ...
Agis-Balboa, Agis-Balboa, Agmon, Akk, Akk, Atack, Atack, Bahari-Javan, Banke, Baram, Belelli, Belelli, Belelli, Belelli, Ben-Ari, Ben-Ari, Ben-Ari, Ben-Ari, Bicikova, Blaesse, Bosman, Bourg, Brinton, Brown, Brown, Brown, Butt, Callachan, Cannon, Cellot, Chisari, Cossart, Craig, Crestani, Darbra, Dehorter, Deidda, Del Rio, Do Rego, Do Rego, Doischer, Farrant, Forte, Francis, Franklin, Frau, Fritschy, Gee, Girolamo, Gizerian, Glickfeld, Goldstein, Grobin, Grobin, Grobin, Grobin, Gunn, Gunn, Gunn, Harrison, Hausrat, Heim, Herd, Herd, Hoftman, Hosie, Huntsman, Ivy, Jacob, Jacobson, Jevtovic-Todorovic, Jones, Jones, Jüttner, Kanes, Kessler, Kilb, Kirmse, Korosi, Laurie, Lavoie, Le Magueresse, Lee, Lobo, Locci, Luhmann, Luhmann, Majewska, Maris, Marques-Smith, Melcangi, Mesbah-Oskui, Mody, Mòdol, Nakamura, Neuchterlein, Oh, Okada, Olsen, Olsen, Owens, Panzica, Papadopoulos, Papadopoulos, Patchev, Paysan, Peden, Peters, Pinna, Pinna, Porcu, Purdy, Reddy, Reddy, Reddy, Rice, Rovo, Rudy, Saalmann, Sauer, Schmidt, Schüle, Scioli-Salter, Sernagor, Shu, Shu, Stephens, Takahashi, Tamamaki, Teicher, Thomas, Tokuda, Tremblay, Vallée, Vallée, Vicini, Vida, Volkow, Walker, Wang, Xiao-Jing, Ye, Zhu, Zilberter, Zorumski   +144 more
core   +2 more sources

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Combined liquid and solid-phase extraction improves quantification of brain estrogen content

Frontiers in Neuroanatomy, 2011
Accuracy in quantifying brain-derived steroid hormones (‘neurosteroids’) has become increasingly important for understanding the modulation of neuronal activity, development, and physiology.
Andrew eChao, Andrew eChao, Barney A Schlinger, Luke eRemage-Healey, Luke eRemage-Healey   +4 more
doaj   +1 more source

Clock-Controlled Mitochondrial Dynamics Correlates with Cyclic Pregnenolone Synthesis

Cells, 2020
Neurosteroids are steroids synthetized in the nervous system, with the first step of steroidogenesis taking place within mitochondria with the synthesis of pregnenolone. They exert important brain-specific functions by playing a role in neurotransmission,
Melissa Witzig, Amandine Grimm, Karen Schmitt, Imane Lejri, Stephan Frank, Steven A. Brown, Anne Eckert   +6 more
doaj   +1 more source

Alfaxalone population pharmacokinetics in the rat: Model application for pharmacokinetic and pharmacodynamic design in inbred and outbred strains and sexes

Pharmacology Research & Perspectives, 2022
The translation of new injectable anesthetic drugs from rodent to humans remains slow, despite the realization that reliance on the volatile agents is unsustainable from an environmental perspective. The aim of this study was to investigate the influence
Kate White, Mohammed Aldurdunji, John Harris, Catherine Ortori, Stuart Paine   +4 more
doaj   +1 more source

Microglial Cell Morphology and Phagocytic Activity Are Critically Regulated by the Neurosteroid Allopregnanolone: A Possible Role in Neuroprotection

Cells, 2021
Microglial cells are key players in neural pathogenesis and microglial function regulation appears to be pivotal in controlling neuroinflammatory/neurological diseases.
Valérie Jolivel, Susana Brun, Fabien Binamé, Jérémie Benyounes, Omar Taleb, Dominique Bagnard, Jérôme De Sèze, Christine Patte-Mensah, Ayikoe-Guy Mensah-Nyagan   +8 more
doaj   +1 more source

An iEEG investigation on sex‐specific differences in seizure duration

Epilepsia Open, EarlyView.
Abstract Objective Male people with epilepsy (mPWE) are at higher risk for bilateral tonic–clonic seizures (BTCs) and sudden unexpected death in epilepsy (SUDEP) compared to female people with epilepsy (fPWE). Despite major clinical and personal implications, little is known about sex‐specific differences in seizure propagation and termination ...
Paula Albert I Gracenea, Alexandra Muss, Magdalena Seethaler, Jan Rémi, Elisabeth Kaufmann   +4 more
wiley   +1 more source

Neuroactive Steroids Reverse Tonic Inhibitory Deficits in Fragile X Syndrome Mouse Model

Frontiers in Molecular Neuroscience, 2019
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. A reduction in neuronal inhibition mediated by γ-aminobutyric acid type A receptors (GABAARs) has been implicated in the pathophysiology of FXS.
Amit Modgil, Thuy N. Vien, Michael A. Ackley, James J. Doherty, Stephen J. Moss, Stephen J. Moss, Paul A. Davies   +6 more
doaj   +1 more source