Results 81 to 90 of about 14,599 (210)
GRKs and arrestins: Nomenclature and functions in GPCR‐dependent and ‐independent signalling
British Journal of Pharmacology, Volume 183, Issue 11, Page 2619-2633, June 2026.G protein‐coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins.
Vsevolod V. Gurevich
wiley +1 more source
Neurotensin as Modulator of Glutamatergic Signalling: Relevance in Neurodegenerative Diseases
, 2009 Rationale: Neurotensin (NT) is a tridecapeptide widely distributed in mammalian brain, where acts as a neurotransmitter or neuromodulator of classical neurotransmitters, mainly through the activation of its receptor NTS1.
Mazza, Roberta
core
Diabetes, Obesity and Metabolism, Volume 28, Issue S3, Page 3-15, June 2026.ABSTRACT The duodenum has historically been regarded as a passive digestive conduit for nutrient transit and absorption. However, emerging experimental and clinical evidence supports a revision of this view. In a contemporary model, the proximal small intestine also has roles as a metabolic sensor and endocrine signalling hub that exerts a powerful ...
David A. D’Alessio +1 more
wiley +1 more source
Desensitization of neurotensin-induced phosphoinositide hydrolysis in transfected CHO cells.
, 1996 The regulation of neurotensin-induced phosphoinositide turnover was studied in transfected CHO cells expressing the rat neurotensin receptor. Stimulation of these cells with neurotensin resulted in an important, but transient, increase in inositol ...
Maloteaux, Jean-Marie, Hermans, Emmanuel
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, 1990 This paper compares the localization of neurotensin receptors and of endopeptidase 24–16, a peptidase likely involved in the inactivation of neurotensin in primary cultures of neurons.
J Mazella +3 more
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Gastrointestinal neurotensin receptors: lack of modulation by thyrotropin releasing hormone
, 1985 To examine whether thyrotropin releasing hormone (TRH) antagonized gastrointestinal neurotensin receptors in isolated segments of the rat fundus, duodenum and ileum, tissues were superfused, mounted and the isometric tension recorded.
J Pablo Huidobro-Toro, M Veronica Donoso
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Utilizing Peptide Ligand GPCRs to Image and Treat Pancreatic Cancer
Biomedicines, 2018 It is estimated that early detection of pancreatic ductal adenocarcinoma (PDAC) could increase long-term patient survival by as much as 30% to 40% (Seufferlein, T. et al., Nat. Rev. Gastroenterol. Hepatol. 2016, 13, 74–75).
Gail L. Matters, John F. Harms
doaj +1 more source
Discovery of Highly Potent and Neurotensin Receptor 2 Selective Neurotensin Mimetics
, 2016 The neurotensin receptor subtype 2 (NTS2) is involved in the modulation of tonic pain sensitivity and psychiatric diseases and is, therefore, regarded as a highly attractive pharmacological target protein.
Cornelia Held (2204758) +6 more
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Neurotensin-like immunoreactivity in the nervous system of hydra
, 1981 Neurotensin-like immunoreactivity is found in nerve fibers present in all body regions of hydra. The nerve fibers are especially numerous in the ectoderm at the bases of the tentacles and in the ectoderm at a site just above the foot.
Sundler, F +3 more
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Neurotensin enhances glutamate excitotoxicity in mesencephalic neurons in primary culture
, 2002 The tridecapeptide neurotensin has been demonstrated to increase glutamate release in discrete rat brain regions, leading to the hypothesis of a possible involvement of the peptide in neurodegenerative pathologies.
FERRARO, Luca Nicola +8 more
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