Results 71 to 80 of about 14,599 (210)

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

Neurotensin colocalizes with orexin in LHA neurons.

, 2013
A, Immunostaining of neurotensin in a coronal section of mouse brain. Dense staining of neurotensin-like immunoreactivity is observed in the central nucleus of the amygdala (CeA), lateral hypothalamic area (LHA) and zona incerta (ZI).
Seiji Shioda (204796), Natsuko Tsujino (169784), Masashi Yanagisawa (224823), Mari Hondo (204857), Haruaki Kageyama (404473), Michihiro Mieda (219471), Naoki Furutani (169799), Takeshi Sakurai (144574)   +7 more
core   +1 more source

Effect of Chewing Gum on Bowel Function Recovery in Elderly Patients Following Posterior Lumbar Fusion Surgery: A Randomized Controlled Trial

Orthopaedic Surgery, Volume 18, Issue 8, Page 1641-1648, August 2026.
Chewing gum did not improve early bowel recovery after lumbar fusion. ABSTRACT Objective Given the paucity of prospective randomized evidence on chewing gum for postoperative bowel recovery in elderly spinal fusion patients, this study aimed to assess the efficacy of chewing gum in improving bowel function recovery in the elderly after posterior lumbar
Fuze Liu, Yifei Li, Gaoyang Li, Xiaoyan He, Lin Zhang, Meijia Zhang, Tian Liu, Ying Jiang, Qinlu Wang, Yaping Chen, Hai Wang   +10 more
wiley   +1 more source

Phospholipase C activation by neurotensin and neuromedin N in Chinese hamster ovary cells expressing the rat neurotensin receptor.

, 1992
The rat neurotensin receptor cDNA sequence was transfected in Chinese hamster ovary cells and cellular clones which stably express the corresponding protein were isolated and characterized.
Maloteaux, Jean-Marie, Hermans, Emmanuel, Octave, Jean-Noël   +2 more
core   +1 more source

Improvement in blastocyst quality by neurotensin signaling via its receptors in bovine spermatozoa during in vitro fertilization

The Journal of Reproduction and Development, 2019
Previously, we reported that neurotensin (NT), which is expressed in the uterus and oviduct, enhanced bovine sperm capacitation and acrosome reactions.
Kohei UMEZU, Risa YAJIMA, Yuuki HIRADATE, Rin YANAI, Takashi NUMABE, Kenshiro HARA, Toshinori OIKAWA, Kentaro TANEMURA   +7 more
doaj   +1 more source

Serum neurotensin in human pancreatic cancer

, 1996
The role of neurotensin as a physiologic regulator of exocrine pancreatic secretion is known, but the hormone has only recently been recognized as important mitogen in vitro for human cancer cells.
Del Favero G, Meggiato T, PLEBANI, MARIO, De Paoli M, Ferrara C, Naccarato R., Tessari G   +6 more
core   +2 more sources

Novel opioid-neurotensin-based hybrid peptide with spinal long-lasting antinociceptive activity and a propensity to delay tolerance development

Acta Pharmaceutica Sinica B, 2020
The behavioral responses exerted by spinal administration of the opioid-neurotensin hybrid peptide, PK23, were studied in adult male rats. The antinociceptive effect upon exposure to a thermal stimulus, as well as tolerance development, was assessed in ...
Karolina Frączek, Mattia Ferraiolo, Emmanuel Hermans, Magdalena Bujalska-Zadrozny, Kaja Kasarello, Anna Erdei, Kamila Kulik, Agnieszka Kowalczyk, Piotr Wojciechowski, Dorota Sulejczak, Piotr Sosnowski, Sebastian Granica, Sandor Benyhe, Katarzyna Kaczynska, Lukasz Nagraba, Artur Stolarczyk, Agnieszka Cudnoch-Jedrzejewska, Patrycja Kleczkowska   +17 more
doaj   +1 more source

Intrinsic conformational equilibria position arrestin‐2 for activation

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Arrestins regulate G protein‐coupled receptor (GPCR) signaling by undergoing large‐scale conformational rearrangements, yet the solution‐state equilibria that underlie arrestin pre‐activation remain poorly defined. While prior studies identified slow conformational exchange at the interdomain interface, these minor states could not be ...
Tucker J. Shriver, Kerem Kahraman, Mingzhe Pan, Çağdaş Dağ, Marco Tonelli, Scott A. Robson, Joshua J. Ziarek   +6 more
wiley   +1 more source

Neurotensin, a biologically active peptide

, 1978
Neurotensin, a tridecapeptide appears to be localized in various parts of the brain and gut. A high affinity binding component of neurotensin to brain membranes, synaptosomes and mast cells has been reported.
Manberg, Paul, Prange, Arthur J, Nemeroff, Charles B, Bissette, Garth   +3 more
core   +1 more source

Theranostic Value of Multimers: Lessons Learned from Trimerization of Neurotensin Receptor Ligands and Other Targeting Vectors

Pharmaceuticals, 2017
Neurotensin receptor 1 (NTS1) is overexpressed on a variety of cancer entities; for example, prostate cancer, ductal pancreatic adenocarcinoma, and breast cancer.
Simone Maschauer, Jürgen Einsiedel, Dominik Reich, Harald Hübner, Peter Gmeiner, Hans-Jürgen Wester, Olaf Prante, Johannes Notni   +7 more
doaj   +1 more source