Results 1 to 10 of about 122 (89)

Preparation and Preliminary Evaluation of Neurotensin Radiolabelled with ⁶⁸Ga and ¹⁷⁷Lu as Potential Theranostic Agent for Colon Cancer

Pharmaceutics, 2021
The neurotensin is a tridecapeptide involved in the proliferation of colon cancer, the overexpression of neurotensin receptors occurring at an early stage development of many tumours.
Radu Anton Leonte, Livia Elena Chilug, Radu Șerban, Cosmin Mustăciosu, Alina Raicu, Gina Manda, Dana Niculae   +6 more
doaj   +1 more source

Stability of the neurotensin receptor NTS1 free in detergent solution and immobilized to affinity resin. [PDF]

PLoS ONE, 2010
Purification of recombinant membrane receptors is commonly achieved by use of an affinity tag followed by an additional chromatography step if required. This second step may exploit specific receptor properties such as ligand binding.
Jim F White, Reinhard Grisshammer
doaj   +1 more source

Unravelling the mechanism of neurotensin recognition by neurotensin receptor 1

Nature Communications, 2023
The conformational ensembles of G protein-coupled receptors (GPCRs) include inactive and active states. Spectroscopy techniques, including NMR, show that agonists, antagonists and other ligands shift the ensemble toward specific states depending on the ...
Kazem Asadollahi, Sunnia Rajput, Lazarus Andrew de Zhang, Ching-Seng Ang, Shuai Nie, Nicholas A. Williamson, Michael D. W. Griffin, Ross A. D. Bathgate, Daniel J. Scott, Thomas R. Weikl, Guy N. L. Jameson, Paul R. Gooley   +11 more
doaj   +1 more source

The role of Neurotensin and its receptors in non-gastrointestinal cancers: a review

Cell Communication and Signaling, 2020
Background Neurotensin, originally isolated in 1973 has both endocrine and neuromodulator activity and acts through its three main receptors. Their role in promoting tumour cell proliferation, migration, DNA synthesis has been studied in a wide range of ...
Stella Nikolaou, Shengyang Qiu, Francesca Fiorentino, Constantinos Simillis, Shahnawaz Rasheed, Paris Tekkis, Christos Kontovounisios   +6 more
doaj   +1 more source

Visualization of real-time receptor endocytosis in dopamine neurons enabled by NTSR1-Venus knock-in mice

Frontiers in Cellular Neuroscience, 2022
Dopamine (DA) neurons are primarily concentrated in substantia nigra (SN) and ventral tegmental area (VTA). A subset of these neurons expresses the neurotensin receptor NTSR1 and its putative ligand neurotensin (Nts). NTSR1, a G protein-coupled receptor (
Aliza T. Ehrlich, Aliza T. Ehrlich, Pierre Couvineau, Selin Schamiloglu, Stefan Wojcik, Dillon Da Fonte, Amina Mezni, Mark von Zastrow, Kevin J. Bender, Michel Bouvier, Brigitte L. Kieffer, Brigitte L. Kieffer   +11 more
doaj   +1 more source

Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer

Communications Biology, 2021
Budzinski et al use bivalent ligands, BRET assays and radioligand competition to demonstrate a specific interaction between two receptors associated with neuropsychiatric diseases and addiction, dopamine D3 (D3R) and neurotensin receptor 1.
Julian Budzinski, Simone Maschauer, Hiroyuki Kobayashi, Pierre Couvineau, Hannah Vogt, Peter Gmeiner, Anna Roggenhofer, Olaf Prante, Michel Bouvier, Dorothee Weikert   +9 more
doaj   +1 more source

Data set describing the in vitro biological activity of JMV2009, a novel silylated neurotensin(8–13) analog

Data in Brief, 2020
Neurotensin (NT) is a tridecapeptide displaying interesting antinociceptive properties through its action on its receptors, NTS1 and NTS2. Neurotensin-like compounds have been shown to exert better antinociceptive properties than morphine at equimolar ...
Élie Besserer-Offroy, Pascal Tétreault, Rebecca L Brouillette, Adeline René, Alexandre Murza, Roberto Fanelli, Karyn Kirby, Alexandre Parent, Isabelle Dubuc, Nicolas Beaudet, Jérôme Côté, Jean-Michel Longpré, Jean Martinez, Florine Cavelier, Philippe Sarret   +14 more
doaj   +1 more source

A Marine Analgesic Peptide, Contulakin-G, and Neurotensin are Distinct Agonists for Neurotensin Receptors: Uncovering Structural Determinants of Desensitization Properties

Frontiers in Pharmacology, 2015
Neurotensin receptors have been studied as molecular targets for the treatment of pain, schizophrenia, addiction, or cancer. Neurotensin (NT) and Contulakin-G, a glycopeptide isolated from a predatory cone snail Conus geographus, share a sequence ...
Hee-Kyoung eLee, Liuyin eZhang, Misty D Smith, Aleksandra eWalewska, Aleksandra eWalewska, Nadeem eVellore, Riccardo eBaron, J Michael eMcIntosh, H Steve eWhite, Baldomero M Olivera, Grzegorz eBulaj   +10 more
doaj   +1 more source

Bright fluorescence monitoring system utilizing Zoanthus sp. green fluorescent protein (ZsGreen) for human G-protein-coupled receptor signaling in microbial yeast cells. [PDF]

PLoS ONE, 2013
G-protein-coupled receptors (GPCRs) are currently the most important pharmaceutical targets for drug discovery because they regulate a wide variety of physiological processes.
Yasuyuki Nakamura, Jun Ishii, Akihiko Kondo   +2 more
doaj   +1 more source

The Anti-Apoptotic Role of Neurotensin

Cells, 2013
The neuropeptide, neurotensin, exerts numerous biological functions, including an efficient anti-apoptotic role, both in the central nervous system and in the periphery.
Jean Mazella, Thierry Coppola, Sophie Béraud-Dufour, Christelle Devader   +3 more
doaj   +1 more source