Results 21 to 30 of about 538,837 (164)

Oncogenic role of neurotensin and neurotensin receptors in various cancers [PDF]

Clinical and Experimental Pharmacology and Physiology, 2017
SummaryNeurotensin (NTS) has long been recognized as a neurotransmitter or neuromodulator in the central nervous system and as an endocrine agent in the periphery via actions mediated through neurotensin receptors (NTSRs). Many studies support a role for NTS in the endocrine, autocrine and paracrine growth stimulation of cancer, with oncogenic actions ...
Qing Ouyang, Ji Zhou, Wei Yang, Hongjuan Cui, Minhui Xu, Liang Yi   +5 more
openaire   +2 more sources

Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK1/2and cell proliferationviaGαq-mediated mechanism [PDF]

, 2014
Dimerization of G protein-coupled receptors (GPCRs) is crucial for receptor function including agonist affinity, efficacy, trafficking and specificity of signal transduction, including G protein coupling.
Cai, X, Jiang, Y, Karteris, E, Bai, B, Chen, J, Karteris, Emmanouil, Bai, Bo, Jiang, Yunlu, Cai, Xin, Chen, Jing   +9 more
core   +1 more source

Regulation of fat-stimulated neurotensin secretion in healthy subjects [PDF]

, 2008
CONTEXT: Cholecystokinin (CCK) and neurotensin are stimulated during meal intake by the presence of fat in the small intestine. The sequence of events suggests that fat hydrolysis is crucial for triggering the release.
Drewe, J., Beglinger, C., Mihailovic, S., D'Amato, M.   +3 more
core   +1 more source

Thermostabilization of the Neurotensin Receptor NTS1

Journal of Molecular Biology, 2009
Structural studies on G-protein-coupled receptors have been hampered for many years by their instability in detergent solution and by the number of potential conformations that receptors can adopt. Recently, the structures of the beta(1) and beta(2) adrenergic receptors and the adenosine A(2a) receptor were determined in the antagonist-bound state, a ...
Shibata, Yoko, White, Jim F., Serrano Vega, Maria J., Aloia, Amanda L., Grisshammer, Reinhard, Tate, Christopher G., MAGNANI, FRANCESCA   +6 more
openaire   +3 more sources

The Role of Intra-Amygdaloid Neurotensin and Dopamine Interaction in Spatial Learning and Memory

Biomedicines, 2022
Neurotransmitter and neuromodulator neurotensin (NT) has been proved to facilitate spatial and passive avoidance learning after microinjected into the rat central nucleus of amygdala (CeA).
Bettina Réka László, Erika Kertes, Tamás Ollmann, László Péczely, Anita Kovács, Zoltán Karádi, László Lénárd, Kristóf László   +7 more
doaj   +1 more source

Neurotensin: A role in substance use disorder? [PDF]

, 2016
Neurotensin is a tridecapeptide originally identified in extracts of bovine hypothalamus. This peptide has a close anatomical and functional relationship with the mesocorticolimbic and nigrostriatal dopamine system. Neural circuits containing neurotensin
Ferraro, Luca, FERRARO, Luca Nicola, Tiozzo Fasiolo, Laura, Antonelli, Tiziana, Pomierny-Chamioło, Lucyna, Frankowska, Małgorzata, Tomasini, Maria C., Fuxe, Kjell, Beggiato, Sarah, Borelli, Andrea C., Pomierny Chamiolo, L, TOMASINI, Maria Cristina, Filip, M., Frankowska, M, Filip, Małgorzata, BORELLI, Andrea Celeste, Fuxe, K   +16 more
core   +2 more sources

Peptide ligand recognition by G protein-coupled receptors

Frontiers in Pharmacology, 2015
The past few years have seen spectacular progress in the structure determination of G protein-coupled receptors (GPCRs). We now have structural representatives from classes A, B, C, and F.
Brian E Krumm, Reinhard eGrisshammer
doaj   +1 more source

Neurotensin analogs by fluoroglycosylation at N ω-carbamoylated arginines for PET imaging of NTS1-positive tumors

Scientific Reports, 2022
Since neurotensin (NT) receptors of subtype-1 (NTS1) are expressed by different types of malignant tumors, such as pancreatic adenocarcinoma, colorectal and prostate carcinoma, they represent an interesting target for tumor imaging by positron emission ...
Lisa Schindler, Katrin Wohlfahrt, Lara Gluhacevic von Krüchten, Olaf Prante, Max Keller, Simone Maschauer   +5 more
doaj   +1 more source

Sortilin in Glucose Homeostasis: From Accessory Protein to Key Player?

Frontiers in Pharmacology, 2019
The pharmacological properties and physiological roles of the type I receptor sortilin, also called neurotensin receptor-3, are various and complex.
Nicolas Blondeau, Sophie Béraud-Dufour, Patricia Lebrun, Céline Hivelin, Thierry Coppola   +4 more
doaj   +1 more source

Neurotensin Decreases the Proinflammatory Status of Human Skin Fibroblasts and Increases Epidermal Growth Factor Expression

International Journal of Inflammation, 2014
Fibroblasts colonization into injured areas during wound healing (WH) is responsible for skin remodelling and is also involved in the modulation of inflammation, as fibroblasts are immunologically active.
Lucília Pereira da Silva, Bruno Miguel Neves, Liane Moura, Maria Teresa Cruz, Eugénia Carvalho   +4 more
doaj   +1 more source