Results 31 to 40 of about 538,837 (164)

Dynamic tuneable G protein-coupled receptor monomer-dimer populations

Nature Communications, 2018
Evidence suggests oligomerisation of G protein-coupled receptors in membranes, but this is controversial. Here, authors use single-molecule and ensemble FRET, and spectroscopy to show that the neurotensin receptor 1 forms multiple dimer conformations ...
Patricia M. Dijkman, Oliver K. Castell, Alan D. Goddard, Juan C. Munoz-Garcia, Chris de Graaf, Mark I. Wallace, Anthony Watts   +6 more
doaj   +1 more source

The Emerging Role of Neuropeptides in Parkinson’s Disease

Frontiers in Aging Neuroscience, 2021
Parkinson’s disease (PD), the second most common age-related neurodegenerative disease, results from the loss of dopamine neurons in the substantia nigra. This disease is characterized by cardinal non-motor and motor symptoms.
Yanan Zheng, Linlin Zhang, Junxia Xie, Junxia Xie, Limin Shi, Limin Shi   +5 more
doaj   +1 more source

Interactions between neurotensin receptors and G proteins. [PDF]

, 2006
International audienceThree neurotensin (NT) receptors have been cloned to date, two of which, NTS1 and NTS2, belong to the family of seven transmembrane domain receptors coupled to G proteins (GPCRs).
Pelaprat, Didier
core   +1 more source

Ventral midbrain NTS1 receptors mediate conditioned reward induced by the neurotensin analogue, D-Tyr[11]neurotensin

Frontiers in Neuroscience, 2015
The present study was aimed at characterizing the mechanisms by which neurotensin (NT) is acting within the ventral midbrain to induce a psychostimulant-like effect. In a first experiment, we determine which subtype(s) of NT receptors is involved in the
Khalil eRouibi, Poulomee eBose, Pierre Paul eRompre, Richard A Warren   +3 more
doaj   +1 more source

Neurotensin contributes to pediatric intestinal failure-associated liver disease via regulating intestinal bile acids uptakeResearch in context

EBioMedicine, 2018
Although the pathogenesis of intestinal failure (IF)-associated liver disease (IFALD) is uncertain, IF-associated cholestasis mediated by the combination of intestinal injury and parenteral nutrition (PN) can lead to disturbed hepatocyte bile acids (BA ...
Yongtao Xiao, Weihui Yan, Ying Lu, Kejun Zhou, Wei Cai   +4 more
doaj   +1 more source

Effect of D1- and D2-like Dopamine Receptor Antagonists on the Rewarding and Anxiolytic Effects of Neurotensin in the Ventral Pallidum

Biomedicines, 2022
Background: Neurotensin (NT) acts as a neurotransmitter and neuromodulator in the central nervous system. It was shown previously that NT in the ventral pallidum (VP) has rewarding and anxiolytic effects. NT exerts its effect in interaction with dopamine
Tamás Ollmann, László Lénárd, László Péczely, Beáta Berta, Erika Kertes, Olga Zagorácz, Edina Hormay, Kristóf László, Ádám Szabó, Rita Gálosi, Zoltán Karádi, Veronika Kállai   +11 more
doaj   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie International Edition, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +1 more source

Construction optimization and functional applications of fluorescent nanodiamonds

Responsive Materials, EarlyView.
This review summarizes synthesis, surface modification and optical properties of fluorescent nanodiamonds. Their advances in quantum sensing, single‐photon emission and biomedicine are discussed, and existing challenges and future directions are presented.
Yunpeng Yang, Sen Zhang, Chao Chen, Wensi Yang, Zuanquan Chen, Rui Fan, Linlin Liu, Benjian Liu, Kang Liu, Zhibo Zhang, Bing Dai, Jiaqi Zhu   +11 more
wiley   +1 more source

Structure of the agonist-bound neurotensin receptor [PDF]

Nature, 2012
Neurotensin (NTS) is a 13-amino-acid peptide that functions as both a neurotransmitter and a hormone through the activation of the neurotensin receptor NTSR1, a G-protein-coupled receptor (GPCR). In the brain, NTS modulates the activity of dopaminergic systems, opioid-independent analgesia, and the inhibition of food intake; in the gut, NTS regulates a
White, Jim F., Noinaj, Nicholas, Shibata, Yoko, Love, James, Kloss, Brian, Xu, Feng, Gvozdenovic-Jeremic, Jelena, Shah, Priyanka, Shiloach, Joseph, Tate, Christopher G., Grisshammer, Reinhard   +10 more
openaire   +2 more sources

A Specific tRNA Half, 3'tiRNA‐GlyGCC, Regulates Hypoxic Pulmonary Artery Smooth Muscle Cell Proliferation via Myrf‐Mediated Endoplasmic Reticulum Stress

Cell Proliferation, EarlyView.
A schematic diagram illustrating how 3′tiRNA‐GlyGCC promotes the endoplasmic reticulum stress (ERS) and proliferation in hypoxic pulmonary artery smooth muscle cells (PASMCs) by inhibiting the expression of myelin regulatory factor (Myrf), ultimately leading to pulmonary hypertension (PH).
Lixin Zhang, Xiaoyu Guan, Xiangrui Zhu, Yingying Hao, Ya Xu, Hao Yuan, Danni Gao, Hongxia Du, Jiayu Li, Weiwei Cao, Cui Ma, Xiaoying Wang   +11 more
wiley   +1 more source