Results 41 to 50 of about 538,837 (164)

Intravenous Oxytocin Does Not Affect Glucose‐Regulating Hormones or Markers of Bone Turnover During Graded Glucose Infusion in Healthy Men

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim Oxytocin has been proposed to exert glucose‐stabilising effects via modulation of pancreatic hormone secretion and to play a role in bone homeostasis. However, human data under controlled conditions are limited. We investigated the effects of intravenously infused oxytocin during a graded glucose infusion on glucose‐regulating hormones and
Vivian Kliim‐Hansen, Ida M. Gether, Aliya M. Thomas, Anne‐Marie Ellegaard, Miriam G. Pedersen, Jens J. Holst, Bolette Hartmann, Filip K. Knop, Lærke S. Gasbjerg, Asger B. Lund   +9 more
wiley   +1 more source

Gastrointestinal neurotensin receptors: lack of modulation by thyrotropin releasing hormone

, 1985
To examine whether thyrotropin releasing hormone (TRH) antagonized gastrointestinal neurotensin receptors in isolated segments of the rat fundus, duodenum and ileum, tissues were superfused, mounted and the isometric tension recorded.
J Pablo Huidobro-Toro, M Veronica Donoso
core   +1 more source

Conotoxins: Therapeutic Potential and Application

Marine Drugs, 2006
The pharmacological variety of conotoxins, diverse peptides found in the venoms of marine cone snails, is well recognized. Venoms from each of the estimated 500 species of cone snails contain 50 to 200 distinct biologically active peptides.
Richard T. Layer, J. Michael McIntosh
doaj   +1 more source

Ligands selectively tune the local and global motions of neurotensin receptor 1 (NTS1)

Cell Reports, 2023
Summary: Nuclear magnetic resonance (NMR) studies have revealed that fast methyl sidechain dynamics can report on entropically-driven allostery. Yet, NMR applications have been largely limited to the super-microsecond motional regimes of G protein ...
Fabian Bumbak, Miquel Pons, Asuka Inoue, Juan Carlos Paniagua, Fei Yan, Hongwei Wu, Scott A. Robson, Ross A.D. Bathgate, Daniel J. Scott, Paul R. Gooley, Joshua J. Ziarek   +10 more
doaj   +1 more source

Admixture Mapping Reveals Candidate Regions for Methotrexate Neurotoxicity Susceptibility: A Reducing Disparities in Acute Leukemia Consortium Report

Pediatric Blood &Cancer, Volume 73, Issue 10, October 2026.
ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris, Priya B. Shetty, Olga A. Taylor, Elizabeth G. Atkinson, Melissa A. Richard, M. Monica Gramatges, Mark Zobeck, Sandi Pruitt, Amy Hughes, M. Brooke Bernhardt, Ashley Chavana, Van Huynh, Kathleen Ludwig, Laura Klesse, Kenneth Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, Han Chen, Bing Yu, Philip J. Lupo, Karen R. Rabin, Michael E. Scheurer, Austin L. Brown, The REDIAL Consortium   +24 more
wiley   +1 more source

Neuropeptide G Protein-Coupled Receptors as Oncotargets

Frontiers in Endocrinology, 2018
Neuropeptide G protein-coupled receptors (GPCRs) are overexpressed on numerous cancer cells. In a number of tumors, such as small cell lung cancer (SCLC), bombesin (BB) like peptides and neurotensin (NTS) function as autocrine growth factors whereby they
Terry W. Moody, Irene Ramos-Alvarez, Robert T. Jensen   +2 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, Volume 600, Issue 17, Page 2437-2450, September 2026.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Colocalization of neurotensin receptors and of the neurotensin- degrading enzyme endopeptidase 24-16 in primary cultures of neurons

, 1990
This paper compares the localization of neurotensin receptors and of endopeptidase 24–16, a peptidase likely involved in the inactivation of neurotensin in primary cultures of neurons.
J Mazella, J Chabry, JP Vincent, F Checler   +3 more
core   +1 more source

Comparison of in vitro and in vivo Properties of HYNIC- [βAla7-Tle12] Neurotensin (5-13) Labeled with 99mTc using Two Co-ligand Systems [PDF]

Journal of Mazandaran University of Medical Sciences, 2023
Background and purpose: The selection of co-ligand has a profound effect on the labeling efficiency, biodistribution, and tumor-targeting ability of 99mTc-labeled HYNIC-conjugated peptides. This study compared the in-vitro and in-vivo properties from the
Iman Emrariani, Nourollah Sadeghzadeh, Saeid Abediankenari, Seyed Mohammad Abedi   +3 more
doaj  

Psychodermatology of the Female: Hormones, Skin and Mental Health Across the Lifespan

JEADV Clinical Practice, Volume 5, Issue 3, Page 769-776, September 2026.
Hormonal transitions across the female lifespan shape skin disease and psychiatric comorbidity through the brain–skin axis and Neuro‐Immuno‐Cutaneous‐Endocrine (NICE) network. This narrative review links puberty, menstruation, pregnancy, postpartum and menopause to dermatologic and psychosocial outcomes.
Sheila Sharifi, Jessica Gulati, Veranca Shah, Keira Barr, Mohammad Jafferany   +4 more
wiley   +1 more source