Results 61 to 70 of about 538,837 (164)
Key-Protease Inhibition Regimens Promote Tumor Targeting of Neurotensin Radioligands
Pharmaceutics, 2020 Neurotensin subtype 1 receptors (NTS1R) represent attractive molecular targets for directing radiolabeled neurotensin (NT) analogs to tumor lesions for diagnostic and therapeutic purposes.
Panagiotis Kanellopoulos +5 more
doaj +1 more source
Bipolar Disorders, Volume 28, Issue 5, August 2026.ABSTRACT Background Cognitive impairment is common in bipolar disorder (BD), but the underlying pathophysiology remains unclear. This systematic review aimed to (1) summarize all literature describing relationships of biofluid biomarkers and cognition in BD and (2) identify which biofluid biomarkers correlate most consistently with cognition in BD ...
Alexandra J. M. Beunders +21 more
wiley +1 more source
Bromotyrosine-derived natural products: synthetic and biological studies [PDF]
, 2011 Bromotyrosine-derived natural products are a fascinating class of compounds that are produced by marine sponges of the order Verongida. Furthermore, they exhibit a rich variety of chemical structures and display a diverse range of bioactivities which ...
core +2 more sources
Current Research in BiotechnologyThe simultaneous activation of both neurotensin type 1 and 2 receptors (NTS1R and NTS2R) through the neuronal peptide neurotensin (NT), activating the dopamine (DA) release and DA signaling within the dopaminergic system in the brain, suggest that NTS1R ...
Kiril Kirilov +13 more
doaj +1 more source
Cell Transplantation, 1995 Mesencephalic cell suspensions were prepared from E12 wild-type (+/+) mouse embryos and stereotaxically implanted into the dorsal neostriatum of weaver mutant mice (wv/wv), which have a genetic mesostriatal dopamine (DA) deficiency.
L.C. Triarhou +6 more
doaj +1 more source
Fluorescent ligands for studying neuropeptide receptors by confocal microscopy
Brazilian Journal of Medical and Biological Research, 1998 This paper reviews the use of confocal microscopy as it pertains to the identification of G-protein coupled receptors and the study of their dynamic properties in cell cultures and in mammalian brain following their tagging with specific fluorescent ...
A. Beaudet +5 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley +1 more source
Functional Characterization of Neurotensin Receptors in Human Cutaneous T Cell Lymphoma Malignant Lymphocytes [PDF]
, 2001 Cutaneous T cell lymphomas are a clonal proliferation of CD4+ T lymphocytes primarily involving the skin. Mycosis fungoides is an epidermotropic CD4+ cutaneous T cell lymphoma, and a more aggressive form, Sezary syndrome, occurs when the malignant cells ...
Bagot, Martine +8 more
core +1 more source
Orthopaedic Surgery, Volume 18, Issue 8, Page 1641-1648, August 2026.Chewing gum did not improve early bowel recovery after lumbar fusion. ABSTRACT Objective Given the paucity of prospective randomized evidence on chewing gum for postoperative bowel recovery in elderly spinal fusion patients, this study aimed to assess the efficacy of chewing gum in improving bowel function recovery in the elderly after posterior lumbar
Fuze Liu +10 more
wiley +1 more source
Neuropeptides Exert Neuroprotective Effects in Alzheimer's Disease
Frontiers in Molecular Neuroscience, 2019 Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by cognitive deficits and neuronal loss. Deposition of beta-amyloid peptide (Aβ) causes neurotoxicity through the formation of plaques in brains of Alzheimer's disease ...
Xin-Yi Chen +3 more
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