Results 71 to 80 of about 538,837 (164)

The hindbrain‐hypothalamic noradrenergic pathway controls homeostatic food intake but not cue‐induced appetitive behaviors

Journal of Neuroendocrinology, Volume 38, Issue 7, July 2026.
Abstract Nucleus of the solitary tract (NTS) A2 noradrenergic neurons are critical in regulating food intake. In addition to their well‐established role in homeostatic feeding, there is also evidence indicating their contribution in non‐homeostatic feeding behaviors. However, whether their control of homeostatic and non‐homeostatic feeding behaviors is
Colin Vuong, Jo Ann Yap, Helen Yi Sha Gu, Hun Yee Lai, Zhi Yi Ong   +4 more
wiley   +1 more source

A Review of the Role of Neurotensin and Its Receptors in Colorectal Cancer

Gastroenterology Research and Practice, 2017
Neurotensin (NTS) is a physiologically occurring hormone which affects the function of the gastrointestinal (GI) tract. In recent years, NTS, acting through its cellular receptors (NTSR), has been implicated in the carcinogenesis of several cancers.
Shengyang Qiu, Gianluca Pellino, Francesca Fiorentino, Shahnawaz Rasheed, Ara Darzi, Paris Tekkis, Christos Kontovounisios   +6 more
doaj   +1 more source

Effect of neurotensin on cultured mouse preimplantation embryos

The Journal of Reproduction and Development, 2020
Previously, we revealed that neurotensin (NTS) derived from the oviduct and uterus can function during fertilization. However, little is known about NTS actions on the pre-implantation embryo after fertilization.
Yuki HIRADATE, Kenshiro HARA, Kentaro TANEMURA   +2 more
doaj   +1 more source

Intrinsic conformational equilibria position arrestin‐2 for activation

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Arrestins regulate G protein‐coupled receptor (GPCR) signaling by undergoing large‐scale conformational rearrangements, yet the solution‐state equilibria that underlie arrestin pre‐activation remain poorly defined. While prior studies identified slow conformational exchange at the interdomain interface, these minor states could not be ...
Tucker J. Shriver, Kerem Kahraman, Mingzhe Pan, Çağdaş Dağ, Marco Tonelli, Scott A. Robson, Joshua J. Ziarek   +6 more
wiley   +1 more source

GRKs and arrestins: Nomenclature and functions in GPCR‐dependent and ‐independent signalling

British Journal of Pharmacology, Volume 183, Issue 11, Page 2619-2633, June 2026.
G protein‐coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins.
Vsevolod V. Gurevich
wiley   +1 more source

The Duodenal Mucosa Plays a Key Role in Metabolic Regulation: Emerging Physiology and New Opportunities for Cell‐Directed and Barrier‐Related Interventions for the Treatment of Diabetes and Obesity

Diabetes, Obesity and Metabolism, Volume 28, Issue S3, Page 3-15, June 2026.
ABSTRACT The duodenum has historically been regarded as a passive digestive conduit for nutrient transit and absorption. However, emerging experimental and clinical evidence supports a revision of this view. In a contemporary model, the proximal small intestine also has roles as a metabolic sensor and endocrine signalling hub that exerts a powerful ...
David A. D’Alessio, Jonathan E. Campbell   +1 more
wiley   +1 more source

Neurotensin as Modulator of Glutamatergic Signalling: Relevance in Neurodegenerative Diseases

, 2009
Rationale: Neurotensin (NT) is a tridecapeptide widely distributed in mammalian brain, where acts as a neurotransmitter or neuromodulator of classical neurotransmitters, mainly through the activation of its receptor NTS1.
Mazza, Roberta
core  

Neurotensin reduces the affinity of dopamine D2 receptors in membranes from post mortem human caudate-putamen

, 1990
The effects of neurotensin in vitro were investigated on the binding characteristics of N-[3H]propylnorapomorphine ([3H]NPA) binding sites in crude membrane preparations from post mortem human caudate-putamen, obtained within 10 h after death from 3 ...
Fuxe, Kjell, VONEULER, G, Vanderhaeghen, Jean-Jacques, MAILLEUX, P, FUXE, K, Mailleux, Pierre, von Euler, Gabriel, VANDERHAEGHEN, JJ   +7 more
core   +1 more source

Conformational Changes in Tyrosine 11 of Neurotensin Are Required to Activate the Neurotensin Receptor 1

ACS Pharmacology & Translational Science, 2020
Cell-cell communication via endogenous peptides and their receptors is vital for controlling all aspects of human physiology and most peptides signal through G protein-coupled receptors (GPCRs). Disordered peptides bind GPCRs through complex modes for which there are few representative crystal structures.
Fabian Bumbak, Trayder Thomas, Billy J. Noonan-Williams, Tasneem M. Vaid, Fei Yan, Alice R. Whitehead, Shoni Bruell, Martina Kocan, Xuan Tan, Margaret A. Johnson, Ross A. D. Bathgate, David K. Chalmers, Paul R. Gooley, Daniel J. Scott   +13 more
openaire   +5 more sources

INCREASED BRAIN NEUROTENSIN AND NTSR2 LEAD TO WEAK NOCICEPTION IN NTSR3/SORTILIN KNOCKOUT MICE

Frontiers in Neuroscience, 2016
The neuropeptide neurotensin (NT) elicits numerous pharmacological effects through three different receptors (NTSR1, NTSR2 and NTSR3 also called sortilin).
Christelle Devader, Sébastien Moreno, Morgane Roulot, Emmanuel Deval, Thomas Dix, Carlos Morales, Jean Mazella   +6 more
doaj   +1 more source