Results 91 to 100 of about 538,837 (164)

Cancer Selectivity of Tetrabranched Neurotensin Peptides Is Generated by Simultaneous Binding to Sulfated Glycosaminoglycans and Protein Receptors

, 2016
In previous papers we demonstrated that tetrabranched peptides containing the sequence of human neurotensin, NT4, are much more selective than native monomeric analogues for binding to different human cancer cells and tissues.
Andrea Bernini (188169), Lorenzo Depau (1941985), Barbara Lelli (304652), Silvia Scali (304654), Niccolò Ravenni (1941988), Chiara Falciani (304645), Jlenia Brunetti (304651), Alessandro Pini (304660), Luisa Lozzi (304647), Luisa Bracci (304657)   +9 more
core   +1 more source

Cancer selectivity of tetrabranched neurotensin peptides is generated by simultaneous binding to sulfated glycosaminoglycans and protein receptors.

, 2013
In previous papers we demonstrated that tetrabranched peptides containing the sequence of human neurotensin, NT4, are much more selective than native monomeric analogues for binding to different human cancer cells and tissues.
Lorenzo Depau, RAVENNI, NICCOLO', FALCIANI, CHIARA, Jlenia Brunetti, Barbara Lelli, Luisa Bracci, BRUNETTI, JLENIA, Andrea Bernini, BERNINI, ANDREA, LELLI, BARBARA, DEPAU, LORENZO, Chiara Falciani, Alessandro Pini, BRACCI, LUISA, Silvia Scali, Niccolò Ravenni, SCALI, SILVIA, Luisa Lozzi, LOZZI, LUISA, PINI, ALESSANDRO   +19 more
core   +1 more source

Biochemische und funktionelle Charakterisierung zellfrei exprimierter G-Protein-gekoppelter Rezeptoren des humanen Endothelin-Systems [PDF]

, 2011
G-protein coupled receptors (GPCRs) are the key players in signal perception and transduction and one of the currently most important class of drug targets.
Junge, Friederike Alessandra
core  

Neurotensin induces hypothermia by activating both neuronal neurotensin receptor 1 and astrocytic neurotensin receptor 2 in the median preoptic nucleus

Neuropharmacology, 2020
Neurotensin (NTS) is a neuropeptide acting as a neuromodulator in the brain and is a very potent hypothermic agent. However, the cellular mechanisms of actions are not fully understood. Here we report that NTS increases the firing rate of preoptic GABAergic neurons by activating both neurotensin receptor 1 (NTSR1) and neurotensin receptor 2 (NTSR2 ...
openaire   +3 more sources

In vitro pharmacological profile of new bifunctional opioid-neurotensin hybrid peptides at human opioid receptors

, 2018
Pain is a major health problem, and the main reason patients seek medical attention. Opioid drugs are the most effective analgesics, but they also produce many side effects such as respiratory depression, constipation, sedation, reward/euphoria, nausea ...
Kunze, Linda
core   +3 more sources

Radiolabeled Peptides: Valuable Tools for the Detection and Treatment of Cancer

Theranostics, 2012
Human cancer cells overexpress many peptide receptors as molecular targets. Radiolabeled peptides that bind with high affinity and specificity to the receptors on tumor cells hold great potential for both diagnostic imaging and targeted radionuclide ...
M. Fani, H. R. Maecke, S. M. Okarvi
doaj  

Improvement in blastocyst quality by neurotensin signaling via its receptors in bovine spermatozoa during in vitro fertilization

The Journal of Reproduction and Development, 2019
Previously, we reported that neurotensin (NT), which is expressed in the uterus and oviduct, enhanced bovine sperm capacitation and acrosome reactions.
Kohei UMEZU, Risa YAJIMA, Yuuki HIRADATE, Rin YANAI, Takashi NUMABE, Kenshiro HARA, Toshinori OIKAWA, Kentaro TANEMURA   +7 more
doaj   +1 more source

Characterization of high affinity neurotensin receptor NTR1 in HL-60 cells and its down regulation during granulocytic differentiation

, 1999
1 We investigated responses to neurotensin in human promyelocytic leukaemia HL-60 cells. 2 Neurotensin increased the cytosolic calcium concentration ([Ca2+](i)) in a concentration-dependent manner and also produced inositol 1,4,5-trisphosphate (InsP(3)).
Kyong-Tai Kim, Hyunjung Ha, Ha, Hyunjung, Choi, SY, Hee-Don Chae, Ha, HJ, Park, TJ, Park, Tae-Ju, Choi, Se-Young, Se-Young Choi, Kim, KT, Chae, HD, Tae-Ju Park, Kim, Kyong-Tai, Chae, Hee-Don   +14 more
core   +1 more source

Immunocytochemical identification of low-affinity NTS2 neurotensin receptors in parietal cells of human gastric mucosa.

, 2006
The biological effects of neurotensin (NT) are mediated by two distinct G protein-coupled receptors, NTS(1) and NTS(2). Although it is well established that neurotensin inhibits gastric acid secretion in man, the plasma membrane receptor mediating these ...
Schulz, S;Röcken, C;Ebert, MP;Schulz, S
core   +1 more source

Docking of virtual libraries identifies small-molecule agonists of neurotensin receptors with analgesic activity

Nature Communications
Peptide-activated G protein-coupled receptors (GPCRs) play crucial roles in numerous diseases, but remain difficult therapeutic targets due to the challenges in developing small-molecule drugs.
Nicolas Panel, Duy Duc Vo, Harald Hübner, Mattia Deluigi, Szymon Pach, Félix Bélair, Dorothee Weikert, Christoph Klenk, Mark Hilge, Niharika Shiva, Isabelle Brochu, Jean-Michel Longpré, Frida Bällgren, Aljona Saleh, Huabin Hu, Jon Kapla, Stefanie Kampen, Israel Cabeza de Vaca, Jan Kihlberg, Nina Wettschureck, Philippe Sarret, Andreas Plückthun, Peter Gmeiner, Jens Carlsson   +23 more
doaj   +1 more source