Results 101 to 110 of about 538,837 (164)

Autoradiographic and electrophysiological evidence for the existence of neurotensin receptors on cultured astrocytes.

, 1995
By means of autoradiography we have studied the cellular localization of binding sites for [3H]neurotensin and its nonpeptide receptor antagonist [3H]SR-48692 in explant cultures of rat neocortex, striatum, brain stem and spinal cord.
Hösli E, Stauffer S, Hösli L
core   +1 more source

Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs

International Journal of Nanomedicine, 2014
Antonella Accardo,1 Luigi Aloj,2 Michela Aurilio,2 Giancarlo Morelli,1 Diego Tesauro11Centro interuniversitario di Ricerca sui Peptidi Bioattivi (CIRPeB), Department of Pharmacy and Istituto di Biostrutture e Bioimmagini - Consiglio Nazionale delle ...
Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D   +4 more
doaj  

Neurotensin and cholecystokinin octapeptide control synergistically dopamine release and dopamine D2 receptor affinity in rat neostriatum

, 1993
Combined perfusion of the neostriatum with 1 nM of cholecystokinin octapeptide (CCK-8) and 0.01, 0.1 or 1 nM of neurotensin was done in the halothane-anesthetized rat after systemic apomorphine treatment (0.05 mg/kg, s.c.). Neurotensin (1 nM) plus CCK-8 (
BIANCHI, Clementina, FERRARO, Luca Nicola, VON EULER G, LI XM, TANGANELLI, Sergio, BEANI, Lorenzo, O'CONNOR WT, FUXE K.   +7 more
core   +1 more source

High affinity receptors but not low affinity receptors for neurotensin are involved in neuronal Na/K-ATPase inhibition by the peptide [PDF]

, 2013
Neurotensin acts as a neuromodulator or as a neurotransmitter that binds to a group of receptors. Two of the receptors, namely NTS1 and NTS2, bind to neurotensin with high affinity and low affinity, respectively.
Gutnisky, Alicia, Rodriguez, Georgina Emma, Alvarez Juliá, Anabel, López Ordieres, María Graciela   +3 more
core   +1 more source

Identification of Variable Lymphocyte Receptors That Target the Human Blood–Brain Barrier

Pharmaceutics
Background/Objectives: Receptor-mediated transcytosis utilizing the native transporters at the blood–brain barrier (BBB) is a growing strategy for the delivery of therapeutics to the brain.
Moriah E. Katt, Elizabeth A. Waters, Benjamin D. Gastfriend, Brantley R. Herrin, Max D. Cooper, Eric V. Shusta   +5 more
doaj   +1 more source

A single class of neurotensin receptors with high affinity in neuroblastoma X glioma NG108-15 hybrid cells that mediate facilitation of synaptic transmission

, 1984
Receptor binding of [3H]neurotensin was examined on membrane preparations derived from neuroblastoma X glioma NG108–15 hybrid cells. The specific binding was saturable and reversible, and a dissociation constant (Kd) was calculated to be about 0.24 nM ...
H Higashida, Y Nakagawa, N Miki
core   +1 more source

Characterization of brain neurotensin receptors using a new tool : levocabastine

, 1989
Levocabastine, a non-peptide antihistamine compound, inhibits, with high affinity and selectivity, neurotensin binding to the low affinity neurotensin sites (NTL-sites) in rat, mouse and hamster brain but not in various other mammalian species including ...
Schotte, Alain
core  

RhoA-mediated G12-G13 signaling maintains muscle stem cell quiescence and prevents stem cell loss

Cell Discovery
Multiple processes control quiescence of muscle stem cells (MuSCs), which is instrumental to guarantee long-term replenishment of the stem cell pool.
Yundong Peng, Jingjing Du, Rui Li, Stefan Günther, Nina Wettschureck, Stefan Offermanns, Yan Wang, Andre Schneider, Thomas Braun   +8 more
doaj   +1 more source

Structure-based design of macrocyclic peptides to generate functional antibodies against G protein-coupled receptors

Nature Communications
G protein-coupled receptors (GPCRs) are critical to a variety of pathophysiological processes, making them attractive targets for the development of drugs or relevant diagnostic tools.
Marie-Edith Nepveu-Traversy, Malihe Hassanzadeh, Laurent Bruneau-Cossette, Élie Besserer-Offroy, Rebecca Brouillette, Sandra Morissette, Hassan Traboulsi, Karyn Kirby, Alexandre Murza, Jean-Michel Longpré, Billy Breton, Fernand-Pierre Gendron, Simon Gaudreau, Pierre-Luc Boudreault, Philippe Sarret   +14 more
doaj   +1 more source

Regulation of the neurotensin NT(1) receptor in the developing rat brain following chronic treatment with the antagonist SR 48692.

, 2000
International audienceThe aim of the present study was to investigate the role of neurotensin in the regulation of NT(1) receptors during postnatal development in the rat brain.
Lépée-Lorgeoux, Isabelle, Betancur, Catalina, Souazé, Frédérique, Bérod, Anne, Rostène, William, Pélaprat, Didier   +5 more
core   +2 more sources