Results 111 to 120 of about 538,837 (164)
Neurotensin Agonist Induces Differential Regulation of Neurotensin Receptor mRNA [PDF]
Journal of Biological Chemistry, 1997 Frédérique Souazé +2 more
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Characterization of neurotensin bound to the neurotensin receptor: An NMR study.
, 2016 Williamson, P +4 more
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Mechanisms of Regulation of Neurotensin Receptors
Pharmacology & Therapeutics, 1998 Since its discovery in 1973, the neuropeptide neurotensin has been demonstrated to be involved in the control of a broad variety of physiological activities in both the central nervous system and in the periphery.
Emmanuel Hermans, Jean-Marie Maloteaux
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Neurotensin and neurotensin receptors
Trends in Pharmacological Sciences, 1999Neurotensin is a brain and gastrointestinal peptide that fulfils many central and peripheral functions through its interaction with specific receptors. Three subtypes of neurotensin receptors have been cloned. Two of them belong to the family of G protein-coupled receptors, whereas the third one is an entirely new type of neuropeptide receptor and is ...
Jean Mazella, P Kitabgi, J P Vincent
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Characterization of Neurotensin Receptors
Current Protocols in Pharmacology, 2004AbstractThis unit describes procedures for performing competition binding assays with neurotensin receptor subtypes 1 and 2 (NTS1 and NTS2). Binding assays using cloned receptors, brain membranes, and primary cultured mesencephalic neurons are presented. NTS1 binding assays employing either radiolabeled neurotensin or SR 48692 (a nonpeptide neurotensin
Patrick, Kitabgi, Didier, Pélaprat
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Neurotensin and the neurotensin receptor‐3 in microglial cells
Journal of Neuroscience Research, 2005AbstractMicroglia motility plays a crucial role in response to lesion or exocytotoxic damage of the cerebral tissue. The neuropeptide neurotensin elicited the migration of the human microglial cell line C13NJ by a mechanism dependent on both phosphatidylinositol‐3 kinase (PI3 kinase) and mitogen‐activated protein (MAP) kinases pathways.
Stéphane, Martin +3 more
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Neurotensin receptors in the rat bronchi
Regulatory Peptides, 1982The isolated, circular preparations of the left and right bronchi of the rat were examined for mechanical responses to neurotensin (NT) and other vasoactive peptides. NT caused concentration-dependent increases in the isometric tension of the unstimulated preparations, with an apparent affinity higher than for the cholinergic agonists but with ...
P, Aas, K B, Helle
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Therapeutic approaches targeting the neurotensin receptors
Expert Opinion on Therapeutic Patents, 2021Introduction: Neurotensin is a gut-brain peptide hormone, a 13 amino acid neuropeptide found in the central nervous system and in the GI tract. The neurotensinergic system is implicated in various physiological and pathological processes related to neuropsychiatric and metabolic machineries, cancer growth, food, and drug intake.
Malliga R. Iyer, George Kunos
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Neurotensin Receptor Antagonists
Current Pharmaceutical Design, 1995Neurotensin (NT), a peptide hormone widely distributed in the CNS and GI tract of mammals, participates in a wide spectrum of central and peripheral biological functions by interacting with specific membrane bound receptors. Recently, NT receptors related to rat brain and human brain have been cloned and sequenced, and has been shown to belong to the
Prasun K. Chakravarty, Richard W. Ransom
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Receptors for neurotensin in canine small intestine
Peptides, 1991We have previously characterized the neurotensin receptors on the circular smooth muscle (CM) of the canine small intestine (1). In the present studies, using radioligand binding technique, neurotensin receptors were localized on the membranes from deep muscular (DMP) and the submucous plexus while no binding was observed on either the longitudinal ...
S, Ahmad, E E, Daniel
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