First-in-human evaluation of [18F]-AlF-NOTA-neurotensin for NTSR1-targeted imaging of prostate cancer: a head-to-head comparison with [68Ga]Ga-PSMA-617 [PDF]
Annals of MedicineBackground Neurotensin receptor-1 (NTSR1) is a promising target for prostate cancer imaging. This study evaluates the first-in-human NTSR1-directed radiotracer [18F]-AlF-NOTA-neurotensin and compares it with [68Ga]Ga-PSMA-617.Methods In a single-centre ...
Jiawei He +6 more
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Unravelling the mechanism of neurotensin recognition by neurotensin receptor 1
Nature Communications, 2023 The conformational ensembles of G protein-coupled receptors (GPCRs) include inactive and active states. Spectroscopy techniques, including NMR, show that agonists, antagonists and other ligands shift the ensemble toward specific states depending on the ...
Kazem Asadollahi +11 more
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Neurotensin inhibits AMPK activity and concurrently enhances FABP1 expression in small intestinal epithelial cells associated with obesity and aging [PDF]
Experimental and Molecular MedicineWe previously demonstrated that neurotensin, a 13-amino-acid gut hormone peptide, enhances small intestinal epithelial cell fatty acid uptake through inhibition of AMPK.
Jing Li +13 more
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Characterisation of neurotensin-expressing interneurons in the mouse spinal dorsal horn [PDF]
Molecular PainThe spinal dorsal horn contains numerous excitatory interneurons, which can be assigned to functional classes based on morphological, electrophysiological and neurochemical criteria.
Erika Polgár +5 more
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Capillary Electrophoresis as a Useful Tool to Separate Isomeric Opioid–Neurotensin Hybrid Peptides [PDF]
MoleculesWe developed and validated a capillary electrophoresis (CE) method for the separation of two opioid–neurotensin hybrid peptides, recently presented as potent analgesics being decapeptides with a hybridic nature (i.e., H-Dmt-D-Lys-Phe-Phe-Lys-Lys-Pro-Phe ...
Joanna Zdunek +5 more
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Molecular dynamic of omega-3 compounds as an anti-obesity agent into GPR-120 receptor [PDF]
Pharmacia, 2023 Obesity is a cause of comorbid diseases such as type 2 diabetes mellitus, dyslipidemia, hypertension which is based on low-level chronic inflammation. The GPR-120 receptor plays a role in insulin sensitization which is related to diabetes mellitus which ...
Ida Musfiroh +4 more
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Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness states. [PDF]
PLoS ONE, 2013 Both orexin and neurotensin are expressed in the lateral hypothalamic area (LHA) and have been implicated in the regulation of feeding, motor activity and the reward system.
Naoki Furutani +7 more
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Dietary Protein Level Influences on Neurotensin-immunoreactive Cells in the Chicken Ileum
The Journal of Poultry Science, 2020 Neurotensin is secreted from intestinal N cells in response to the food ingestion. Influences of different dietary protein levels on neurotensin-immunoreactive cells in the chicken ileum were examined by using immunohistochemical and morphometrical ...
Md Salahuddin +2 more
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Frontiers in Cardiovascular Medicine, 2022 BackgroundNeurotensin is involved in fatty acid and glucose metabolism and promotes the development of obesity and diabetes. These associations appear to be more pronounced in women.
Maximilian Tscharre +16 more
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Stability of the neurotensin receptor NTS1 free in detergent solution and immobilized to affinity resin. [PDF]
PLoS ONE, 2010 Purification of recombinant membrane receptors is commonly achieved by use of an affinity tag followed by an additional chromatography step if required. This second step may exploit specific receptor properties such as ligand binding.
Jim F White, Reinhard Grisshammer
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