Results 31 to 40 of about 14,599 (210)

The Role of Intra-Amygdaloid Neurotensin and Dopamine Interaction in Spatial Learning and Memory

Biomedicines, 2022
Neurotransmitter and neuromodulator neurotensin (NT) has been proved to facilitate spatial and passive avoidance learning after microinjected into the rat central nucleus of amygdala (CeA).
Bettina Réka László, Erika Kertes, Tamás Ollmann, László Péczely, Anita Kovács, Zoltán Karádi, László Lénárd, Kristóf László   +7 more
doaj   +1 more source

[Ser7]neurotensin: isolation from guinea pig intestine [PDF]

, 1986
Using three antisera to neurotensin of defined regional specificity, a novel neurotensin has been identified in extracts of guinea pig brain and small intestine.
J.Michael Conlon, Lars Thim, Shaw, Christopher, Thim, Lars, Conlon, J.Michael, Christopher Shaw   +5 more
core   +1 more source

Kinase suppressor of Ras 1 and Exo70 promote fatty acid-stimulated neurotensin secretion through ERK1/2 signaling.

PLoS ONE, 2019
Neurotensin is a peptide hormone released from enteroendocrine cells in the small intestine in response to fat ingestion. Although the mechanisms regulating neurotensin secretion are still incompletely understood, our recent findings implicate a role for
Stephanie Rock, Xian Li, Jun Song, Courtney M Townsend, Heidi L Weiss, Piotr Rychahou, Tianyan Gao, Jing Li, B Mark Evers   +8 more
doaj   +1 more source

Elevated neurotensin levels among obese adolescents may be related to emotion dysregulation and impulsivity: a cross-sectional, case-control study

The Turkish Journal of Pediatrics, 2022
Background. In this study, we aimed to evaluate the serum neurotensin (NT) levels and their relationships with self-reported anxiety, emotion regulation skills and impulsivity in healthy and obese adolescents. Methods.
Gonca Özyurt, Gülten Cingöz, Yusuf Öztürk, Tuncay Küme, Bumin Nuri Dündar, Ali Evren Tufan, Gönül Çatlı   +6 more
doaj   +1 more source

PK20, a new opioid-neurotensin hybrid peptide that exhibits central and peripheral antinociceptive effects

Molecular Pain, 2010
Background The clinical treatment of various types of pain relies upon the use of opioid analgesics. However most of them produce, in addition to the analgesic effect, several side effects such as the development of dependence and addiction as well as ...
Tsuda Yuko, Van den Eynde Isabelle, Ballet Steven, Kosson Piotr, Kleczkowska Patrycja, Tourwé Dirk, Lipkowski Andrzej W   +6 more
doaj   +1 more source

Neurotensin Decreases the Proinflammatory Status of Human Skin Fibroblasts and Increases Epidermal Growth Factor Expression

International Journal of Inflammation, 2014
Fibroblasts colonization into injured areas during wound healing (WH) is responsible for skin remodelling and is also involved in the modulation of inflammation, as fibroblasts are immunologically active.
Lucília Pereira da Silva, Bruno Miguel Neves, Liane Moura, Maria Teresa Cruz, Eugénia Carvalho   +4 more
doaj   +1 more source

Neurotensin and its receptors in the control of glucose homeostasis

Frontiers in Endocrinology, 2012
The pharmacological roles of the neuropeptide neurotensin through its three known receptors are various and complex. Neurotensin is involved in several important biological functions including analgesia and hypothermia in the central nervous system and ...
Jean eMazella, Sophie eBéraud-Dufour, Christelle eDevader, Fabienne eMassa, Thierry eCoppola   +4 more
doaj   +1 more source

NTS Targeted By miR-182 Modulates the Apoptosis of Goat Endometrial Epithelial Cells

Acta Veterinaria, 2019
Neurotensin is a tridecapeptide that functions in prenatal metabolism. It is targeted and downregulated by miR-182 through binding the seed site of miR-182 to the 3′ untranslated region and reduced by a candidate tumor suppressor, testin.
Xiaopeng An, Yue Zhang, Jidan Liu, Xingna Ma, Zhaoyu Guo, Binyun Cao   +5 more
doaj   +1 more source

Identification and in vivo characterization of a brain-penetrating nanobody

Fluids and Barriers of the CNS, 2020
Background Preclinical models to determine blood to brain transport ability of therapeutics are often ambiguous. In this study a method is developed that relies on CNS target-engagement and is able to rank brain-penetrating capacities. This method led to
Y Wouters, T Jaspers, B De Strooper, M Dewilde   +3 more
doaj   +1 more source

Effect of Monoclonal Antibody Blockade of Long Fragment Neurotensin on Weight Loss, Behavior, and Metabolic Traits After High-Fat Diet Induced Obesity

Frontiers in Endocrinology, 2021
BackgroundObesity is a major public health problem of our time as a risk factor for cardiometabolic disease and the available pharmacological tools needed to tackle the obesity pandemic are insufficient.
Zherui Wu, Zherui Wu, Nicolas Stadler, Amazigh Abbaci, Jin Liu, Agnès Boullier, Nicolas Marie, Nicolas Marie, Olivier Biondi, Marthe Moldes, Marthe Moldes, Romain Morichon, Bruno Feve, Bruno Feve, Olle Melander, Olle Melander, Patricia Forgez   +16 more
doaj   +1 more source