Results 41 to 50 of about 14,599 (210)
Comparison of in vitro and in vivo Properties of HYNIC- [βAla7-Tle12] Neurotensin (5-13) Labeled with 99mTc using Two Co-ligand Systems [PDF]
Journal of Mazandaran University of Medical Sciences, 2023 Background and purpose: The selection of co-ligand has a profound effect on the labeling efficiency, biodistribution, and tumor-targeting ability of 99mTc-labeled HYNIC-conjugated peptides. This study compared the in-vitro and in-vivo properties from the
Iman Emrariani +3 more
doaj
Pharmaceutics, 2022 Introduction: Neurotensin receptor 1 (NTSR1) is an emerging target for imaging and therapy of many types of cancer. Nuclear imaging of NTSR1 allows for noninvasive assessment of the receptor levels of NTSR1 on the primary tumor, as well as potential ...
Hailey A. Houson +5 more
doaj +1 more source
Angewandte Chemie International Edition, EarlyView.Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma +5 more
wiley +1 more source
Neurotensin induces catalepsy in mice
, 1982 Intracerebroventricular (i.c.v.) injection of neurotensin (NT) induced catalepsy in mice at doses greater than or equal to 0.02 μg. The cataleptic effect progressively increased, reaching a maximum at approx. 2 hr after injection.
Nemeroff, C.B +4 more
core +1 more source
Brain Delivery of IGF1R5, a Single-Domain Antibody Targeting Insulin-like Growth Factor-1 Receptor
Pharmaceutics, 2022 The ability of drugs and therapeutic antibodies to reach central nervous system (CNS) targets is greatly diminished by the blood–brain barrier (BBB). Receptor-mediated transcytosis (RMT), which is responsible for the transport of natural protein ligands ...
Alvaro Yogi +10 more
doaj +1 more source
Rapid Communications in Mass Spectrometry, EarlyView.ABSTRACT Rationale Recent advances in high‐throughput molecular analyses of collagen peptides, especially ZooMS (Zooarchaeology by Mass Spectrometry), have permitted breakthroughs in the analysis of archaeological material that is highly fragmented, a factor that hinders morphological identification.
Pauline Raymond +8 more
wiley +1 more source
Neurotensin: an endogenous antipsychotic?
, 2002 Despite evidence from a variety of experimental approaches implicating the neuropeptide neurotensin in both the mechanism of action of antipsychotic drugs and the pathophysiology of schizophrenia, there has been some debate as to whether a peripherally ...
Nemeroff, Charles B, Kinkead, Becky
core +1 more source
Construction optimization and functional applications of fluorescent nanodiamonds
Responsive Materials, EarlyView.This review summarizes synthesis, surface modification and optical properties of fluorescent nanodiamonds. Their advances in quantum sensing, single‐photon emission and biomedicine are discussed, and existing challenges and future directions are presented.
Yunpeng Yang +11 more
wiley +1 more source
, 1998 Neurotensin is a neurotransmitter present in the brain and gastrointestinal tract. Intracerebroventricular injection of neurotensin protects rats from gastric mucosal injury caused by cold water restraint (CWR).
Gordon L. Kauffman +2 more
core +1 more source
Frontiers in Pharmacology, 2023 Background: Paclitaxel-induced peripheral neuropathy (PN) is a serious clinical problem with no approved drug for prevention. This study aimed to examine the neuroprotective effect of metformin against paclitaxel-induced PN in breast cancer patients ...
Hala M. Bakry +3 more
doaj +1 more source