Results 51 to 60 of about 538,837 (164)

Neurotensin receptors in Parkinson's disease and progressive supranuclear palsy: an autoradiographic study in basal ganglia.

, 1990
The technique of receptor autoradiography was used to study the distribution of neurotensin receptors in post mortem brain tissues from patients affected by Parkinson's disease, progressive supranuclear palsy and from age-matched controls.
Palacios JM, Chinaglia G, Probst A
core   +1 more source

The transfection of BDNF to dopamine neurons potentiates the effect of dopamine D3 receptor agonist recovering the striatal innervation, dendritic spines and motor behavior in an aged rat model of Parkinson's disease.

PLoS ONE, 2015
The progressive degeneration of the dopamine neurons of the pars compacta of substantia nigra and the consequent loss of the dopamine innervation of the striatum leads to the impairment of motor behavior in Parkinson's disease.
Luis F Razgado-Hernandez, Armando J Espadas-Alvarez, Patricia Reyna-Velazquez, Arturo Sierra-Sanchez, Veronica Anaya-Martinez, Ismael Jimenez-Estrada, Michael J Bannon, Daniel Martinez-Fong, Jorge Aceves-Ruiz   +8 more
doaj   +1 more source

Cancer Neuroscience: From Local Neuro–Immune Microenvironments to Systemic Brain–Body Circuitry

MedComm, Volume 7, Issue 9, September 2026.
This review outlines the cancer neuroscience paradigm, spanning systemic brain–body circuitry and local neuro–immune–tumor microenvironments. We discuss how tumors promote axonogenesis and pseudo‐synapse formation, and how sensory neuropeptides, such as CGRP, contribute to CD8+ T‐cell exhaustion.
Mingxuan Xie, Yu Zhao, Xinruo Xing, Yuqiang Liu, Jungang Zhao, Maojin Yao, Jun Tang, Jianzhu Zhao   +7 more
wiley   +1 more source

Altered neural electrophysiological properties in the anterior cingulate cortex in a mouse model of Prader‐Willi syndrome

The Journal of Physiology, Volume 604, Issue 17, Page 7313-7336, 1 September 2026.
Abstract figure legend Prader‐Willi syndrome (PWS) originates from deficiencies in chromosome 15q11‐13 region clustering around a critical region containing multiple‐repeat non‐coding RNA gene Snord116, resulting in metabolic and behavioural abnormalities leading to hyperphagia and obesity.
Volodymyr Rybalchenko, Ryan Butler
wiley   +1 more source

Rapid agonist-induced decrease of neurotensin receptors from the cell surface in rat cultured neurons

, 1991
The regulation of neurotensin receptors was studied in vitro in primary cultures of neuronal cells. High affinity receptors for [3H]neurotensin were found in homogenates and at the cell surface of intact neurons cultured from the brain of rat embryos ...
Maloteaux, Jean-Marie, Octave, Jean-Noël, Vanisberg, Marie-Agnès, Laduron, Pierre M.   +3 more
core   +1 more source

Developmental dynamics of neurotensin binding sites in the human hypothalamus during the first postnatal year

Frontiers in Cellular Neuroscience, 2014
The aim of the present study was to determine a detailed mapping of neurotensin (NT) in the human hypothalamus during the first postnatal year using an in vitro quantitative autoradiography technique and the selective radioligand monoiodo-Tyr3 ...
Mohamed eNajimi, Alain eSarrieau, Nicolas eKopp, Fatiha eChigr   +3 more
doaj   +1 more source

Comparative analysis of microRNAs in bovine colostrum and neonatal calf blood

Journal of the Science of Food and Agriculture, Volume 106, Issue 10, Page 5799-5809, 15 August 2026.
Abstract BACKGROUND MicroRNAs (miRNAs) are short non‐coding RNAs that participate in a wide range of biological processes. MiRNAs are present in high concentrations in colostrum, and these may be potentially transferred to newborn calves being fed colostrum.
Do T Hue, Kiro Petrovski, Yan Ren, John L Williams, Tong Chen, Wai Y Low, Thien D Van, Cynthia D K Bottema   +7 more
wiley   +1 more source

Synthesis and Characterization of Tritium‐Labeled Neuropeptide Y Y5 Receptor Ligands Derived From CGP71683A

Archiv der Pharmazie, Volume 359, Issue 8, August 2026.
From a synthesized series of 2,4‐diaminoquinazoline‐type Y5R ligands, three were prepared as tritium‐labeled compounds and characterized by saturation equilibrium binding at HEC‐1B‐hY5R cells. [3H]32 was further applied in a competition binding assay. High non‐specific binding of the radioligands prompted investigation of material‐dependent adsorption.
Franziska Schettler, Pierre Koch, Max Keller   +2 more
wiley   +1 more source

Interaction of lipids with the neurotensin receptor 1

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2016
Information about lipid-protein interactions for G protein-coupled receptors (GPCRs) is scarce. Here, we use electron spin resonance (ESR) and spin-labelled lipids to study lipid interactions with the rat neurotensin receptor 1 (NTS1). A fusion protein containing rat NTS1 fully able to bind its ligand neurotensin was reconstituted into ...
Bolivar, Juan H., Muñoz-García, Juan C., Castro-Dopico, Tomas, Dijkman, Patricia M., Stansfeld, Phillip J., Watts, Anthony   +5 more
openaire   +3 more sources

Involvement of the Neurotensin Receptor-3 in the Neurotensin-Induced Migration of Human Microglia [PDF]

The Journal of Neuroscience, 2003
Microglia motility plays a crucial role in response to lesion or exocytotoxic damage of the cerebral tissue. We used two in vitro assays, a wound-healing model and a chemotaxis assay, to show that the neuropeptide neurotensin elicited the migration of the human microglial cell line C13NJ by a mechanism dependent on both phosphatidylinositol 3-kinase ...
Stephane, Martin, Jean-Pierre, Vincent, Jean, Mazella   +2 more
openaire   +2 more sources