Results 91 to 100 of about 25,999 (347)

Central Nervous System Complications in Children Receiving Chemotherapy or Hematopoietic Stem Cell Transplantation

open access: yesFrontiers in Pediatrics, 2017
Therapy-related neurotoxicity greatly affects possibility of survival and quality of life of pediatric patients treated for cancer. Central nervous system (CNS) involvement is heterogeneous, varying from very mild and transient symptoms to extremely ...
Duccio Maria Cordelli   +7 more
doaj   +1 more source

Interleukin‐5, Eosinophils, and Interleukin‐5 Pathway Inhibitors in Eosinophilic Granulomatosis With Polyangiitis

open access: yesArthritis &Rheumatology, EarlyView.
Interlukin‐5 (IL‐5) plays a crucial role in the pathogenesis of eosinophilic granulomatosis with polyangiitis (EGPA) by promoting eosinophil differentiation, activation, and survival. We present here a typical case of EGPA in which treatment with IL‐5 pathway inhibitors is prescribed, showing to be beneficial for the patient.
Alvise Berti, Christian Pagnoux
wiley   +1 more source

Nelarabine-associated central nervous neurotoxicity inducing Guillain-Barre-like/myelopathy: inpatient rehabilitation and functional outcomes

open access: yesJournal of Rehabilitation Medicine - Clinical Communications
Objective: Nelarabine is an antineoplastic agent used in the treatment of acute T-cell lymphoblastic lymphoma with inadequate clinical response to prior chemotherapeutic treatments.
Rachel M. Santiago   +4 more
doaj   +1 more source

Leveraging Epidemiology to Improve Risk Assessment. [PDF]

open access: yes, 2011
The field of environmental public health is at an important crossroad. Our current biomonitoring efforts document widespread exposure to a host of chemicals for which toxicity information is lacking.
Burke, Thomas A   +5 more
core  

Synaptic Plasticity and Neurological Disorders in Neurotropic Viral Infections [PDF]

open access: yes, 2015
Based on the type of cells or tissues they tend to harbor or attack, many of the viruses are characterized. But, in case of neurotropic viruses, it is not possible to classify them based on their tropism because many of them are not primarily neurotropic.
Atluri, Venkata   +4 more
core   +2 more sources

Tacrolimus exposure during pregnancy in kidney and liver transplantation recipients: A comparison between whole blood and plasma concentration‐to‐dose ratios

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tacrolimus monitoring is generally performed in whole blood (WB). Most (>85%) of circulating tacrolimus is bound to red blood cells. During pregnancy, WB monitoring might be suboptimal because of physiological changes including increased plasma volume and decreased haematocrit.
Jildau R. Meinderts   +7 more
wiley   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher   +7 more
wiley   +1 more source

Early intervention for obsessive compulsive disorder : An expert consensus statement [PDF]

open access: yes, 2019
© 2019 Elsevier B.V.and ECNP. All rights reserved.Obsessive-compulsive disorder (OCD) is common, emerges early in life and tends to run a chronic, impairing course. Despite the availability of effective treatments, the duration of untreated illness (DUI)
Albert, Umberto   +24 more
core   +5 more sources

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