Results 121 to 130 of about 105,668 (383)

Safety and Pharmacokinetics of a Four Monoclonal Antibody Combination Against Botulinum C and D Neurotoxins. [PDF]

, 2019
Botulism is caused by botulinum neurotoxin (BoNT), the most poisonous substance known. BoNTs are also classified as Tier 1 biothreat agents due to their high potency and lethality.
Cobb, Ronald R, Conrad, Fraser, Espinoza, Yero, Garcia-Rodriguez, Consuelo, Kimbler, Angie, Kraus, Carl N, Marks, James D, Martinez, Zachary, Pham, Khanh, Riling, Kathryn, Snow, Doris M, Tomic, Milan T, Wong, David   +12 more
core  

Characterization of the spore surface and exosporium proteins of Clostridium sporogenes; implications for Clostridium botulinum group I strains. [PDF]

, 2016
Clostridium sporogenes is a non-pathogenic close relative and surrogate for Group I (proteolytic) neurotoxin-producing Clostridium botulinum strains.
Bullough, Per A., Fagan, Robert P., Hobbs, Jamie K., Janganan, Thamarai K., Moir, Anne, Mullin, Nic, Stringer, Sandra, Tzokov, Svetomir B.   +7 more
core   +2 more sources

The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges

Advanced Science, EarlyView.
This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li, Ying Zhang, Zhenyu Xiao, Jieyu Qi   +3 more
wiley   +1 more source

Saxitoxin Poisoning in Green Turtles (Chelonia mydas) Linked to Scavenging on Mass Mortality of Caribbean Sharpnose Puffer Fish (Canthigaster rostrata-Tetraodontidae)

Frontiers in Veterinary Science, 2019
Fish within the family Tetraodontidae are potential sources of both endogenous tetrodotoxins (TTXs) and dietary derived saxitoxins (STXs). Ingestion of fish tissues containing these toxins by other vertebrates can lead to severe illness and death.
Rocío González Barrientos, Gabriela Hernández-Mora, Fernando Alegre, Theresa Field, Leanne Flewelling, Sara McGrath, Jonathan Deeds, Yajaira Salazar Chacón, Karla Rojas Arrieta, Emilia Calvo Vargas, Karen Berrocal Artavia, Brian A. Stacy   +11 more
doaj   +1 more source

Methylmercury varies more than one order of magnitude in commercial European rice [PDF]

, 2017
P.M. thanks the Royal Thai Government for funding and C.C.B.
Brombach, Christoph-Cornelius, Chen, Bin, Corns, Warren T, Ezzeldin, Mohamed Farouk, Feldmann, Jorg, Kolambage-Dona, Piumi P.P., Krupp, Eva Maria, Manorut, Parinda   +7 more
core   +1 more source

Tumor‐Associated Sympathetic Nerves Promote the Progression of Epstein‐Barr Virus‐Positive Diffuse Large B‐Cell Lymphoma

Advanced Science, EarlyView.
Sympathetic nerve innervation promotes the progression of Epstein‐Barr virus‐positive diffuse large B‐cell lymphoma (EBV+ DLBCL) via β2‐adrenergic receptors. The discovery of enhanced nerve infiltration and β2AR expression reveals a novel mechanism and highlights the sympathetic–β2AR axis as a promising target for therapeutic intervention in EBV+ DLBCL.
Silan Huang, Dexin Lei, Linbin Yang, Aiwei Bi, Yanlou Wang, Peng Zhang, Dongyu Zhuang, Honglian Liu, Qingqing Cai, Man Nie, Yi Xia   +10 more
wiley   +1 more source

Neurotoxinas de invertebrados como alternativas terapéuticas y herramientas en investigación básica Neurotoxins from invertebrates as alternative therapeutic agents and tools in basic research

Vitae, 2009
Los venenos que producen los animales son una mezcla compleja de proteínas, péptidos, enzimas y trazas de elementos no proteicos tales como carbohidratos y sales, cuya finalidad es inmovilizar la presa y comenzar a digerirla.
Jaime A PEREAÑEZ, Leidy J VARGAS
doaj  

Subtype Specificity of β-Toxin Tf1a from Tityus fasciolatus in Voltage Gated Sodium Channels

Toxins, 2018
Scorpion venoms are a complex mixture of components. Among them the most important are peptides, which presents the capacity to interact and modulate several ion channel subtypes, including voltage-gated sodium channels (NaV).
Daniel Oliveira da Mata, Diogo Vieira Tibery, Leandro Ambrósio Campos, Thalita Soares Camargos, Steve Peigneur, Jan Tytgat, Elisabeth Ferroni Schwartz   +6 more
doaj   +1 more source

Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of TLR4 mRNA

Advanced Science, EarlyView.
Alzheimer's disease (AD) progression is influenced by microglia‐mediated neuroinflammation. Here, it is demonstrated that Listerin suppresses neuroinflammatory signaling and cognitive impairment in AD models by triggering IRE1α‐mediated TLR4 mRNA decay. Adenoviral Listerin delivery reduces amyloid‐β pathology, positioning it as a new therapeutic target.
Fei Qin, Runyu Cao, Xuemei Bai, Jiahua Yuan, Wanwei Sun, Yi Zheng, Xiaopeng Qi, Wei Zhao, Bingyu Liu, Chengjiang Gao   +9 more
wiley   +1 more source

Conflicting Clinical Presentation of Infection with Clostridium botulinum and Clostridium perfringens in a 5-Month-Old Infant

Journal of Pediatrics: Clinical Practice
We present a 5-month-old infant with a 1-day history of poor feeding and sudden progression into generalized weakness including septic shock syndrome after consumption of homemade food. Botulism and sepsis symptoms could be explained by the presence of a
Barbara Schaub, MD, Carolyn Luhman-Lunt, MD, Andrea Ott, MD, Maren Krüger, DSc, Martin Skiba, PhD, Sylvia Worbs, PhD, Brigitte G. Dorner, PhD, Michael Buettcher, MD, Martin B. Dorner, PhD   +8 more
doaj