Results 121 to 130 of about 65,558 (345)

NIR‐II Fluorescent Protein Created by In Situ Albumin‐Tagging for Sensitive and Specific Imaging of Blood‐Brain Barrier Disruption

Advanced Science, EarlyView.
The breakdown of the blood‐brain barrier (BBB) after cerebral ischemia can cause brain injury and induce potentially fatal consequences. Currently, there exist few dependable and low‐cost imaging techniques for visualizing the BBB. This investigation effectively engineered an albumin‐specific covalently tagged near‐infrared‐II (NIR‐II) dye, serving as ...
Jiajun Xu, Yijing Du, Ningning Zhu, Jia Li, Yuewei Zhang, Ding Zhou, Shoujun Zhu   +6 more
wiley   +1 more source

Utilizing Caenorhabditis Elegans as a Rapid and Precise Model for Assessing Amphetamine‐Type Stimulants: A Novel Approach to Evaluating New Psychoactive Substances Activity and Mechanisms

Advanced Science, EarlyView.
This study uses Caenorhabditis elegans to assess the activity of amphetamine‐type stimulants (ATS) and their analogs. The research highlights the roles of dopamine and serotonin pathways, distinguishes chiral forms of ATS, and identifies structure‐activity relationships. These findings provide a rapid and cost‐effective model for evaluating the effects
Yuanpeng Li, Hongyuan Li, Hongshuang Wang, Xiaohui Wang   +3 more
wiley   +1 more source

Early exposure to flame retardants is prospectively associated with anxiety symptoms in adolescents: A prospective birth cohort study

Depression and Anxiety, Volume 39, Issue 12, Page 780-793, December 2022., 2022
Abstract Background Anxiety disorders emerge during childhood and adolescence and are frequently preceded by subsyndromal anxiety symptoms. Environmental toxicants, including gestational polybrominated diphenyl ether (PBDE) exposure, are associated with neuropsychiatric sequelae; however, the role of PBDEs as risk factors for anxiety in adolescence is ...
Jeffrey R. Strawn, Yingying Xu, Kim M. Cecil, Jane Khoury, Mekibib Altaye, Joseph M. Braun, Bruce P. Lanphear, Andreas Sjodin, Aimin Chen, Kimberly Yolton   +9 more
wiley   +1 more source

Applications, impacts and consequences of botulinum toxin usage in medicine

Journal of Education, Health and Sport
Introduction Botulinum toxin is a neurotoxin produced by the gram-positive bacteria Clostridium botulinum. Botulinum toxin has found great interest in the field of aesthetic medicine, but it has many other applications in other areas of medicine.  
Weronika Kiełt, Julia Kozłowska, Gabriela Broniec, Barbara Wajdowicz, Aleksandra Kudła, Rozalia Czapiewska, Aleksandra Dziewulska, Aleksandra Wróbel, Laura Pacek, Klaudia Kowalska   +9 more
doaj   +1 more source

Diatoms: A Novel Source for the Neurotoxin BMAA in Aquatic Environments

PLoS ONE, 2014
Amyotrophic lateral sclerosis (ALS) or Lou Gehrig’s disease is a neurological disorder linked to environmental exposure to a non-protein amino acid, β-N-methylamino-L-alanine (BMAA).
Liying Jiang, L. Eriksson, Sandra Lage, Sara Jonasson, S. Shams, Martin Mehine, L. Ilag, U. Rasmussen   +7 more
semanticscholar   +1 more source

The neurotoxicity of β-N-oxalyl-l-αβ-diaminopropionic acid, the neurotoxin from the pulse Lathyrus sativus [PDF]

, 1969
P. S. Cheema, K. Malathi, G. Padmanaban, P.S. Sarma   +3 more
openalex   +1 more source

Therapeutic Potential of Lipid Nanoparticle‐Encapsulated CD19‐Targeting mRNAs in Lupus and Rheumatoid Arthritis

Advanced Science, EarlyView.
This study develops lipid nanoparticle‐encapsulated mRNA‐encoding antibodies (mRNab‐LNPs) targeting CD19, demonstrating robust anti‐CD19 antibody production in vivo. Intramuscular injection of mRNab‐LNPs reduces CD19+ B and plasma cells in lupus and rheumatoid arthritis mice, significantly alleviating histopathological changes and tissue injuries of ...
Chipeng Guo, Yingsen Tang, Ling Zeng, Xiaomei You, Siweier Luo, Yufei Du, Le Wang, Liangchun Wang, Jianchuan Wang, Jinjin Chen, Yiming Zhou   +10 more
wiley   +1 more source

Functional consequences of brain exposure to saturated fatty acids: From energy metabolism and insulin resistance to neuronal damage

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023
Saturated fatty acids induce insulin resistance in neurons. Neuronal metabolism of palmitic acid alters mitochondrial function. Abstract Introduction Saturated fatty acids (FAs) are the main component of high‐fat diets (HFDs), and high consumption has been associated with the development of insulin resistance, endoplasmic reticulum stress and ...
Karina Sánchez‐Alegría, Clorinda Arias   +1 more
wiley   +1 more source

Presence of the Neurotoxin BMAA in Aquatic Ecosystems: What Do We Really Know?

Toxins, 2014
The neurotoxin β-N-methylamino-l-alanine (BMAA) is suspected to play a role in the neurological diseases amyotrophic lateral sclerosis, Alzheimer’s disease, and Parkinson’s disease.
E. Faassen
semanticscholar   +1 more source

PRODUCTION AND BIOLOGICAL CHARACTERISTICS OF AN EXTRACELLULAR NEUROTOXIN FROM MYCOPLASMA NEUROLYTICUM [PDF]

, 1964
Joseph G. Tully
openalex   +1 more source