Results 131 to 140 of about 65,558 (345)

Rational Design and Organoid‐Based Evaluation of a Cocktail CAR‐γδ T Cell Therapy for Heterogeneous Glioblastoma

Advanced Science, EarlyView.
A novel “prof” cocktail therapy is designed. It screens antigens, selects personalized antigen panels, engineers optimized CAR‐Vδ1 T cells, and tests in patient‐derived GBM organoids, offering hope for effective CAR‐T drugs against heterogeneous solid tumors. Abstract Various challenges, including tumor heterogeneity and inadequate T cell infiltration,
Guidong Zhu, Zhongzheng Sun, Yingchao Liu, Jiang Liu, Linpei Guo, Guojing Pei, Ying Jiang, Baowang Miao, Zhen Li, Ping Zhang, Dongqi Tang, Wen Zhang, Chengwei Wang   +12 more
wiley   +1 more source

Advances in electrochemical detection methods for measuring contaminants of emerging concerns

Electrochemical Science Advances, Volume 2, Issue 6, December 2022., 2022
Abstract The presence of contaminants of emerging concerns (CECs) such as pharmaceuticals and personal care products, endocrine disrupting compounds (EDCs), per/poly‐fluorinated substances (PFAS), pesticides, and nanomaterials poses significant challenges to the environment and human health.
Mohamed H. Hassan, Reem Khan, Silvana Andreescu   +2 more
wiley   +1 more source

Bee Venom Neurotoxin (Apamin): Iodine Labeling and Characterization of Binding Sites [PDF]

, 1979
E. Habermann, Kurt H. Fischer
openalex   +1 more source

Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles

Aggregate, EarlyView.
Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu   +6 more
wiley   +1 more source

Phototherapy via Modulation of β‐Amyloid in Combating Alzheimer's Disease

Aggregate, EarlyView.
This review introduces the light‐regulated Aβ aggregation, highlighting four applications: photodynamic therapy (PDT), photothermal therapy (PTT), photopharmacology, and photobiomodulation (PBM) systems. It also summarizes the current issues and proposes the prospects of photo‐induced modulation of Aβ aggregation and clearance as a therapeutic strategy
Yunhua Zhang, Chengyuan Qian, Yuncong Chen, Weijiang He, Zijian Guo   +4 more
wiley   +1 more source

Utilities of Botulinum Toxins in Dermatology and Cosmetology

Clinical, Cosmetic and Investigational Dermatology, 2021
Piyu Parth Naik Department of Dermatology, Saudi German Hospital and Clinic, Dubai, United Arab EmiratesCorrespondence: Piyu Parth NaikDepartment of Dermatology, Saudi German Hospital and Clinic, Opposite Burj Al Arab, Dubai, United Arab EmiratesTel +971
Naik PP
doaj  

Clostridial neurotoxins [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2004
A, Goonetilleke, J B, Harris
openaire   +2 more sources

Bridging Mechanical Properties with Atomic Structures of Polymorphic α‐Synuclein Fibrils by Single‐Molecule Analysis and Molecular Dynamics Simulations

Aggregate, EarlyView.
α‐Synuclein fibrils exhibit distinct mechanical properties influencing their neurotoxicity and pathogenicity in synucleinopathies like Parkinson's disease. Combining optical tweezers and molecular dynamics simulations, this study builds the structure–mechanics relationships of wild‐type and two disease‐associated mutants E46K and A53T α‐Synuclein ...
Lulu Bi, Linge Li, Xiang Li, Shaojuan Wu, Xia Zhang, Yilin Zhao, Dan Li, Cong Liu, Zhonghuai Hou, Bo Sun   +9 more
wiley   +1 more source

Taipoxin, an Extremely Potent Presynaptic Neurotoxin from the Venom of the Australian Snake Taipan (Oxyuranus s. scutellatus) [PDF]

, 1976
Jan Fohlman, David Eaker, Evert Karlsson, S. Thesleff   +3 more
openalex   +1 more source

The tau isoform 1N4R confers vulnerability of MAPT knockout human iPSC‐derived neurons to amyloid beta and phosphorylated tau‐induced neuronal dysfunction

Alzheimer's &Dementia, EarlyView.
Abstract INTRODUCTION Human tau protein, composed of six brain‐specific isoforms, is a major driver of Alzheimer's disease (AD). The role of its isoforms however remains unclear and human AD models are scarce. METHODS We generated human MAPT– (tau–) knockout (KO) induced pluripotent stem cells (iPSC) using CRISPR/Cas9, differentiated these into ...
Sarah Buchholz, Mohamed Aghyad Al Kabbani, Michael Bell‐Simons, Lena Kluge, Cagla Cagmak, Jennifer Klimek, Natja Haag, Lukas C. Iohan, Audrey Coulon, Marcos R. Costa, Devrim Kilinc, Hans Zempel   +11 more
wiley   +1 more source