Results 131 to 140 of about 132,798 (382)

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, EarlyView.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

Characterization of Induced Pluripotent Stem Cell-derived Human Serotonergic Neurons

Frontiers in Cellular Neuroscience, 2017
In the brain, the serotonergic neurons located in the raphe nucleus are the unique resource of the neurotransmitter serotonin, which plays a pivotal role in the regulation of brain development and functions. Dysfunction of the serotonin system is present
Lining Cao, Rui Hu, Ting Xu, Zhen-Ning Zhang, Weida Li, Jianfeng Lu, Jianfeng Lu   +6 more
doaj   +1 more source

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Tiny Fish, Big Hope: Zebrafish Unlocking Secrets to Fight Parkinson’s Disease

Biology
Parkinson’s disease (PD) is a progressive neurological disorder marked by the gradual loss of dopamine-producing neurons in the brain. This neuronal degradation causes motor symptoms such as tremors, stiffness, and slowness of movement.
Manjunatha Bangeppagari, Akshatha Manjunath, Anusha Srinivasa, Sang Joon Lee   +3 more
doaj   +1 more source

Thermic dehorning and ear tagging as atypical portals of entry of Clostridium tetani in ruminants [PDF]

, 2011
This paper describes two infections with Clostridium tetani (C. tetani). One outbreak occurred after dehorning of calves, the second infection happened after ear tagging of a goat.
Boyen, Filip, De Schutter, Peter, Deprez, Piet, Eeckhaut, Venessa, Pardon, Bart, Valgaeren, Bonnie, Van Immerseel, Filip   +6 more
core   +1 more source

rAAV expressing recombinant neutralizing antibody for the botulinum neurotoxin type A prophylaxis [PDF]

, 2022
Artem A. Derkaev, E. I. Ryabova, I. B. Esmagambetov, Dmitry V. Shcheblyakov, Svetlana A. Godakova, I. D. Vinogradova, A. N. Noskov, Denis Y. Logunov, Boris S. Naroditsky, Gintsburg Al   +9 more
openalex   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Development of a Recombinant Fusion Vaccine Candidate Against Lethal Clostridium botulinum Neurotoxin Types A and B

Vaccines
Background: Botulinum neurotoxins (BoNTs), produced by Clostridium botulinum, are potent protein toxins that can cause botulism, which leads to death or neuroparalysis in humans by targeting the nervous system.
Eun-Sun Choi, Seong-Wook Pyo, So-Hyeon Kim, Jun-Ho Jeon, Gi-Eun Rhie, Mi-Ran Yun, Hwajung Yi, Yoon-Seok Chung   +7 more
doaj   +1 more source

Submandibular gland botulinum neurotoxin A injection for predicting the outcome of submandibular duct relocation in drooling: a retrospective cohort study [PDF]

, 2019
Saskia E. Kok, Hans F J P van Valenberg, Karen van Hulst, Peter H. Jongerius, Corrie E. Erasmus, Frank J. A. van den Hoogen   +5 more
openalex   +1 more source

SAMCEP Society consensus on the treatment of upper facial lines with botulinum neurotoxin type A: A tailored approach [PDF]

, 2023
F Braccini, Isabelle Catoni, F. Belfkira, Jacques Lagier, Emmanuel Roze, J. Paris, James Huth, V. Bronsard, Hugues Cartier, Mengel David, O. Galatoire, D. Obadia, H. Sabatier, E. Sarfati, Philippe Kestemont, Cécile Winter, Alessio Redaelli   +16 more
openalex   +1 more source