Results 31 to 40 of about 77,752 (388)

Quantitative Mass Spectrometry for Bacterial Protein Toxins — A Sensitive, Specific, High-Throughput Tool for Detection and Diagnosis

Molecules, 2011
Matrix-assisted laser-desorption time-of-flight (MALDI-TOF) mass spectrometry (MS) is a valuable high-throughput tool for peptide analysis. Liquid chromatography electrospray ionization (LC-ESI) tandem-MS provides sensitive and specific quantification of
Suzanne Kalb, Conrad P. Quinn, John R. Barr, Hercules Moura, Renato C. Lins, Zsuzsanna Kuklenyik, Adrian Woolfitt, Maribel Gallegos-Candela, Anne E. Boyer   +8 more
doaj   +1 more source

CXCL12/SDF-1 from perisynaptic Schwann cells promotes regeneration of injured motor axonterminals [PDF]

, 2017
The neuromuscular junction has retained through evolution the capacity to regenerate after damage, but little is known on the inter-cellular signals involved in its functional recovery from trauma, autoimmune attacks, or neurotoxins.
Aram Megighian, Bagri A, Cesare Montecucco, Chiara M Mazzanti, Egle Radice, Elisa Duregotti, Elisanna Bergamin, Francesca Lessi, Guyon A, Marco La Ferla, Marco Pirazzini, Marcus Thelen, Michela Rigoni, Michele Menicagli, Paolo Aretini, Samuele Negro, Sara Franceschi, Shellard A   +17 more
core   +1 more source

Tables of Toxicity of Botulinum and Tetanus Neurotoxins

Toxins, 2019
Tetanus and botulinum neurotoxins are the most poisonous substances known, so much so as to be considered for a possible terrorist use. At the same time, botulinum neurotoxin type A1 is successfully used to treat a variety of human syndromes ...
O. Rossetto, C. Montecucco
semanticscholar   +1 more source

Druggability of Voltage-Gated Sodium Channels—Exploring Old and New Drug Receptor Sites

Frontiers in Pharmacology, 2022
Voltage-gated ion channels are important drug targets because they play crucial physiological roles in both excitable and non-excitable cells. About 15% of clinical drugs used for treating human diseases target ion channels.
Goragot Wisedchaisri, Tamer M. Gamal El-Din   +1 more
doaj   +1 more source

Reductive chain separation of botulinum A toxin — a prerequisite to its inhibitory action on exocytosis in chromaffin cells [PDF]

, 1989
Cleavage of the disulfide bond linking the heavy and the light chains of tetanus toxin is necessary for its inhibitory action on exocytotic release ofcatecholamines from permeabi1ized chromaffin cells [(1989) FEBS Lett. 242, 245-248; (1989) J. Neurochern.
Ahnert-Hilger, Ahnert-Hilger, Ahnert-Hilger, Ahnert-Hilger, Ammann, B. Stecher, Bhakdi, Bhakdi, Bittner, Dreyer, Eisel, G. Ahnert-Hilger, Habermann, Habermann, Knight, Knight, Livett, M. Gratzl, Maisey, Marxen, Mellanby, Penner, Poulain, Sellin, Simpson, Weller   +25 more
core   +1 more source

Diversity of the Genomes and Neurotoxins of Strains of Clostridium botulinum Group I and Clostridium sporogenes Associated with Foodborne, Infant and Wound Botulism

Toxins, 2020
Clostridium botulinum Group I and Clostridium sporogenes are closely related bacteria responsible for foodborne, infant and wound botulism. A comparative genomic study with 556 highly diverse strains of C. botulinum Group I and C.
J. Brunt, A. H. V. van Vliet, A. T. Carter, S. Stringer, C. Amar, K. Grant, G. Godbole, M. Peck   +7 more
semanticscholar   +1 more source

The light chain but not the heavy chain of botulinum A toxin inhibits exocytosis from permeabilized adrenal chromaffin cells [PDF]

, 1989
The heavy and light chains of botulinum A toxin were separated by anion exchange chromatography. Their intracellular actions were studied using bovine adrenal chromaffin cells permeabilized with streptolysin O.
Ahnert-Hilger, G., Gratzl, Manfred, Habermann, E., Stecher, B., Weller, U.   +4 more
core   +1 more source

Venomics Approach Reveals a High Proportion of Lactrodectus-Like Toxins in the Venom of the Noble False Widow Spider Steatoda nobilis

Toxins, 2020
The noble false widow spider Steatoda nobilis originates from the Macaronesian archipelago and has expanded its range globally. Outside of its natural range, it may have a negative impact on native wildlife, and in temperate regions it lives in ...
John P. Dunbar, Antoine Fort, Damien Redureau, Ronan Sulpice, Michel M. Dugon, Loïc Quinton   +5 more
doaj   +1 more source

Considerations for the Use of Minimally Invasive Aesthetic Procedures for Facial Remodeling in Transgender Individuals

Clinical, Cosmetic and Investigational Dermatology, 2021
Koenraad De Boulle,1 Nobutaka Furuyama,2 Izolda Heydenrych,3,4 Terrence Keaney,5 Alexander Rivkin,6 Vincent Wong,7 Michael Silberberg8 1Aalst Dermatology Clinic, Aalst, Belgium; 2Jiyugaoka Clinic, Medical Corporation, Tokyo, Japan; 3Cape Town Cosmetic ...
De Boulle K, Furuyama N, Heydenrych I, Keaney T, Rivkin A, Wong V, Silberberg M   +6 more
doaj  

Mitochondrial ROS cause motor deficits induced by synaptic inactivity:implications for synapse pruning [PDF]

, 2018
Developmental synapse pruning refines burgeoning connectomes. The basic mechanisms of mitochondrial reactive oxygen species (ROS) production suggest they select inactive synapses for pruning: whether they do so is unknown.
Batinic-Haberle, Ines, Cobley, James N., Gibson, Jack W., Megson, Ian L., Moult, Peter R., Murphy, Michael P., Sidlauskaite, Eva, Tovmasyan, Artak, Whitfield, Philip D.   +8 more
core   +4 more sources