Results 11 to 20 of about 99,329 (223)
Multilayer adaptive networks in neuronal processing [PDF]
The European Physical Journal Special Topics 227, 1039-1049 (2018), 2022 The connectome is a wiring diagram mapping all the neural connections in the brain. At the cellular level, it provides a map of the neurons and synapses within a part or all of the brain of an organism. In recent years, significant advances have been made in the study of the connectome via network science and graph theory.
arxiv +1 more source
Paired associative stimulation demonstrates alterations in motor cortical synaptic plasticity in patients with hepatic encephalopathy [PDF]
Clinical Neurophysiology, Volume 132, Issue 10, October 2021,
Pages 2332-2341, 2022 Objective: Hepatic encephalopathy (HE) is a potentially reversible brain dysfunction caused by liver failure. Altered synaptic plasticity is supposed to play a major role in the pathophysiology of HE. Here, we used paired associative stimulation with an inter-stimulus interval of 25 ms (PAS25), a transcranial magnetic stimulation (TMS) protocol, to ...
arxiv +1 more source
Long-term memory and synapse-like dynamics in two-dimensional nanofluidic channels [PDF]
Science 379, 161-167 (2023), 2022 Fine-tuned ion transport across nanoscale pores is key to many biological processes such as neurotransmission. Recent advances have enabled the confinement of water and ions to two dimensions, unveiling transport properties unreachable at larger scales and triggering hopes to reproduce the ionic machinery of biological systems.
arxiv +1 more source
Dopamine drives Drosophila sechellia adaptation to its toxic host
eLife, 2014 Many insect species are host-obligate specialists. The evolutionary mechanism driving the adaptation of a species to a toxic host is, however, intriguing.
Sofía Lavista-Llanos +6 more
doaj +1 more source
Risperidone response in patients with schizophrenia drives DNA methylation changes in immune and neuronal systems [PDF]
, 2023 Background: The choice of efficient antipsychotic therapy for schizophrenia relies on a time-consuming trial-and-error approach, whereas the social and economic burdens of the disease call for faster alternatives. Material \& methods: In a search for predictive biomarkers of antipsychotic response, blood methylomes of 28 patients were analyzed before ...
arxiv +1 more source
Increased accuracy of ligand sensing by receptor diffusion on cell surface [PDF]
Physical Review E 82, 041902 (2010), 2010 The physical limit with which a cell senses external ligand concentration corresponds to the perfect absorber, where all ligand particles are absorbed and overcounting of same ligand particles does not occur. Here we analyze how the lateral diffusion of receptors on the cell membrane affects the accuracy of sensing ligand concentration.
arxiv +1 more source
The GABA-Withdrawal Syndrome: A Model of Local Status Epilepticus
Neural Plasticity, 2000 The GABA-withdrawal syndrome (GWS) is a model of local status epilepticus following the interruption of a chronic GABA infusion into the rat somatomotor cortex.
Carmen Silva-Barrat +2 more
doaj +1 more source
Activity-dependent modulation of neural circuit synaptic connectivity
Frontiers in Molecular Neuroscience, 2009 In many nervous systems, the establishment of neural circuits is known to proceed via a two-stage process; 1) early, activity-independent wiring to produce a rough map characterized by excessive synaptic connections, and 2) subsequent, use-dependent
Charles R Tessier, Kendal Broadie
doaj +1 more source
Optical Modulation of Neurotransmission [PDF]
Biophysical Journal, 2013 The computational properties of an isolated neuron have been analyzed in detail by postsynaptic activation with caged compounds. However, new tools are needed to manipulate neurotransmission at individual synapses in order to understand how a neuron integrates physiological stimuli received from presynaptic neurons within a circuit.
Dirk Trauner +3 more
openaire +2 more sources
The role of neurosteroids in the pathogenesis of hepatic encephalopathy [PDF]
Medicinski Podmladak, 2016 Hepatic Encephalopathy (HE) represents a neuropsychiatric syndrome caused by acute or chronic liver failure. Hyperammonemia plays a pivotal role in the development of HE through modulation of neurotransmission, oxidative stress, neuroinflammation ...
Mladenović Dušan +2 more
doaj +1 more source