Results 121 to 130 of about 60,284 (256)
Tetrahydrobiopterin regulates monoamine neurotransmitter sulfonation
, 2017 Significance Human cytosolic sulfotransferases (SULTs) regulate hundreds of signaling small molecules, yet little is known regarding their small-molecule regulation.
Ian Cook, Ting Wang, Thomas S. Leyh
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Advanced Science, EarlyView.Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li +23 more
wiley +1 more source
Advanced Science, EarlyView.The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang +12 more
wiley +1 more source
, 2006 Questions, comments or suggestions about this model may be sent to Dr. Leigh Little, llittle@brockport.edu, The College at Brockport.Students will be able to observe the movement of neurotransmitter molecules across axon terminal membrane into ...
Ibezin, Samuel
core
Cerebral blood flow predicts differential neurotransmitter activity
, 2017 Application of metabolic magnetic resonance imaging measures such as cerebral blood flow in translational medicine is limited by the unknown link of observed alterations to specific neurophysiological processes. In particular, the sensitivity of cerebral
Garry D Honey +24 more
core +1 more source
Advanced Science, EarlyView.Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong +8 more
wiley +1 more source
Permeation Properties of Neurotransmitter Transporters
, 1994 The neurotransmitter transporters belong to three known families of intrinsic membrane proteins (Figure 1). The energy for transport, which is often against the neurotransmitter concentration gradient, is derived from the cotransport (and in some ...
Lester, Henry A. +3 more
core
Advanced Science, EarlyView.A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang +14 more
wiley +1 more source
, 2017 In this study, Serrano-Saiz et al. map the neurotransmitter identity of neurons in the Caenorhabditis elegans male nervous system, thereby providing...
Pereira, Laura +15 more
core +1 more source