Results 221 to 230 of about 537,273 (282)

O‐Terphenyl‐basierte Familie konjugierter Makrozyklen: Selektive Erkennung von Phenylalanin im Wasser und Interaktion mit Insulin

open access: yesAngewandte Chemie, EarlyView.
Diese Studie beschreibt die Herstellung und Eigenschaften einer neuen Familie von o‐Terphenyl‐basierten Makrozyklen, TP[n] (n = 2‐8). Der Trimer bindet Phenylalanin in Wasser sehr effizient und ist dabei zehnmal selektiver als bei anderen Aminosäuren und aromatischen Neurotransmittern.
Swapnil Ghule   +5 more
wiley   +1 more source

Protein‐Driven Copper Redox Regulation: Uncovering the Role of Disulphide Bonds and Allosteric Modulation

open access: yesAngewandte Chemie International Edition, EarlyView.
Copper binding triggers structural changes that expose a reactive disulphide bridge, enabling intrinsic Cu(II) reduction in folded proteins. SAXS, XAS, and QM/MM simulations reveal how globular proteins such as HSA and SOD1 employ disulphide‐mediated dynamics to modulate site accessibility and control copper redox chemistry.
Rebecca Sternke‐Hoffmann   +9 more
wiley   +1 more source

The dual face of human chorionic gonadotropin in the CNS: neuroprotection, signaling, and possible pathological effects. [PDF]

open access: yesArch Gynecol Obstet
Hosseini S   +5 more
europepmc   +1 more source

o‐Terphenyl‐Based Family of Conjugated Macrocycles: Selective Recognition of Phenylalanine in Water and Interaction With Insulin

open access: yesAngewandte Chemie International Edition, EarlyView.
This study presents the synthesis and binding properties of a new family of o‐terphenyl‐based macrocycles, TP[n] (n = 2‐8). The trimer variant efficiently binds phenylalanine in water with a 10‐fold selectivity compared to other amino acids and aromatic neurotransmitters.
Swapnil Ghule   +5 more
wiley   +1 more source

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