Results 81 to 90 of about 470,740 (429)
CNS Mitochondria‐Derived Vesicle in Blood: Potential Biomarkers for Brain Mitochondria Dysfunction
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial dysfunction is a hallmark of neurodegenerative diseases like Alzheimer's (AD) and Parkinson's (PD). Our goal was to develop practical, noninvasive methods to assess mitochondrial status through the detection of mitochondria‐derived vesicles (MDVs).
Qi Liu +12 more
wiley +1 more source
Sargassum horneri Extract Attenuates Depressive-like Behaviors in Mice Treated with Stress Hormone
Antioxidants, 2023 Sargassum horneri, a brown seaweed, is known for its various health benefits; however, there are no reports on its effects on depression. This study aimed to investigate the antidepressant effects of S. horneri ethanol extract (SHE) in mice injected with
Inhye Park +8 more
doaj +1 more source
ATP as a presynaptic modulator [PDF]
, 2000 © 2000 Elsevier Science Inc.There is considerable evidence that ATP acts as a fast transmitter or co-transmitter in autonomic and sensory nerves mostly through activation of ionotropic P2X receptors but also through metabotropic P2Y receptors. By analogy,
Cunha, Rodrigo A., Ribeiro, J. A.
core +1 more source
Arthritis Care &Research, EarlyView.As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox +3 more
wiley +1 more source
ASTROCYTIC CONTROL OF BIOSYNTHESIS AND TURNOVER OF THE NEUROTRANSMITTERS GLUTAMATE AND GABA
Frontiers in Endocrinology, 2013 Glutamate and GABA are the quantitatively major neurotransmitters in the brain mediating excitatory and inhibitory signaling, respectively. These amino acids are metabolically interrelated and at the same time they are tightly coupled to the intermediary
Arne eSchousboe +2 more
doaj +1 more source
Adsorption Kinetic Model Predicts and Improves Reliability of Electrochemical Serotonin Detection
Methods and Protocols, 2023 Serotonin (5-HT) is a neurotransmitter involved in many biophysiological processes in the brain and in the gastrointestinal tract. Electrochemical methods are commonly used to quantify 5-HT, but their reliability may suffer due to the time-dependent ...
Ashley Augustiny Chapin +2 more
doaj +1 more source
Glutamate as a neurotransmitter in the healthy brain
Journal of neural transmission, 2014 Glutamate is the most abundant free amino acid in the brain and is at the crossroad between multiple metabolic pathways. Considering this, it was a surprise to discover that glutamate has excitatory effects on nerve cells, and that it can excite cells to
Yun Zhou, N. Danbolt
semanticscholar +1 more source
Experimental Biology and Medicine, 1973 SummaryStimulation of the cardioaccelerator nerve (CA) in the isolated chicken heart causes the release of norepinephrine and little epinephrine and increases heart rate significantly, but after beta blockade heart rate was depressed indicating the release of cholinergic agent which could be blocked with atropine.
D. W. Poorvin, Paul D. Sturkie
openaire +3 more sources
Advanced Functional Materials, EarlyView.Glioblastoma multiforme is the most devastating and incurable brain tumor. To better study this disease, a 3D model is developed using a hyaluronic acid‐based hydrogel combined with a multicellular approach. This model recapitulates in vivo brain stiffness, cell‐extracellular matrix and cell‐cell interactions and the tumor's hijacking function with the
Mateo S. Andrade Mier +26 more
wiley +1 more source
Cells, 2023 The regulation of the immune environment within the tumor microenvironment has provided new opportunities for cancer treatment. However, an important microenvironment surrounding cancer that is often overlooked despite its significance in cancer ...
Tuan Minh Nguyen +3 more
doaj +1 more source