Bioluminescence-based high-throughput screen identifies pharmacological agents that target neurotransmitter signaling in small cell lung carcinoma. [PDF]
BACKGROUND: Frontline treatment of small cell lung carcinoma (SCLC) relies heavily on chemotherapeutic agents and radiation therapy. Though SCLC patients respond well to initial cycles of chemotherapy, they eventually develop resistance.
Ma Reina D Improgo +3 more
doaj +7 more sources
A computational pipeline for a neurotransmitter-centric analysis of the effects of psychiatric medication on EEG spectral power [PDF]
IntroductionTraditional pharmaco-electroencephalography (EEG) studies have mainly examined the effects of psychotropic medications at the level of individual drugs or broad drug classes, limiting biological specificity and clinical translation.
Samar Samy Zekerallah +9 more
doaj +2 more sources
Neurotransmitters in cancer: how receptor signaling and posttranslational modifications modulate tumor progression and offer new therapeutic targets [PDF]
Recent studies highlight the multifaceted roles of neurotransmitters in tumor immunomodulation, offering novel avenues for increasing therapeutic efficacy.
Xuanyin Ding +9 more
doaj +2 more sources
Antiepileptic potential of ganaxolone [PDF]
nema
Janković Slobodan, Lukić Snežana
doaj +1 more source
Creatine Activity as a Neuromodulator in the Central Nervous System [PDF]
Creatine is a nutritional compound that potentially influences cognitive processing and neuroprotection. Recent evidence has demonstrated that similar to neurotransmitters, creatine is released in an excitotoxic and action potential-dependent manner and ...
G. H Meftahi, B Hatef, G Pirzad Jahromi
doaj +1 more source
Plastic reorganisation of human motor cortex [PDF]
nema
Ilić Tihomir V., Ilić Nela V.
doaj +1 more source
Reviewing the mechanism of propofol addiction
Propofol is widely used as a short-acting intravenous anaesthetic for the induction and maintenance of anaesthetic sedation. The application of propofol is expanding due to its advantages and the increasing demand for painless diagnosis and treatment ...
Tianhao Zhong +5 more
doaj +1 more source
High concentration of dopamine treatment may induce acceleration of human sperm motility
Purpose In humans, catecholamines (including dopamine) have been identified in semen and fallopian tubes, while dopamine D2 receptors (D2DR) are found in the sperm midpiece region.
Hiroki Kanno +5 more
doaj +1 more source
Pathomechanisms of Non-Traumatic Acute Brain Injury in Critically Ill Patients
Delirium, an acute alteration in mental status characterized by confusion, inattention and a fluctuating level of arousal, is a common problem in critically ill patients. Delirium prolongs hospital stay and is associated with higher mortality.
Wojciech Dabrowski +8 more
doaj +1 more source
Neuropharmacologic modulation of the melatonergic system
The circadian rhythm is a critical system that governs an organism’s functions in alignment with the light-dark cycle. Melatonin release from the pineal gland plays a crucial role in regulating the internal clock of the body.
Utku Aykan +3 more
doaj +1 more source

