Results 1 to 10 of about 3,421,322 (249)

The Relationship Between Dopamine Neurotransmitter Dynamics and the Blood-Oxygen-Level-Dependent (BOLD) Signal: A Review of Pharmacological Functional Magnetic Resonance Imaging

Frontiers in Neuroscience, 2018
Functional magnetic resonance imaging (fMRI) is widely used in investigations of normal cognition and brain disease and in various clinical applications. Pharmacological fMRI (pharma-fMRI) is a relatively new application, which is being used to elucidate
Tyler J. Bruinsma, Vidur V. Sarma, Vidur V. Sarma, Yoonbae Oh, Yoonbae Oh, Dong Pyo Jang, Su-Youne Chang, Su-Youne Chang, Greg A. Worrell, Val J. Lowe, Hang Joon Jo, Hang Joon Jo, Hoon-Ki Min, Hoon-Ki Min, Hoon-Ki Min   +14 more
doaj   +2 more sources

Bioluminescence-based high-throughput screen identifies pharmacological agents that target neurotransmitter signaling in small cell lung carcinoma. [PDF]

PLoS ONE, 2011
BACKGROUND: Frontline treatment of small cell lung carcinoma (SCLC) relies heavily on chemotherapeutic agents and radiation therapy. Though SCLC patients respond well to initial cycles of chemotherapy, they eventually develop resistance.
Ma Reina D Improgo, Christopher W Johnson, Andrew R Tapper, Paul D Gardner   +3 more
doaj   +3 more sources

Screening of neurotransmitter receptor modulators reveals novel inhibitors of influenza virus replication [PDF]

Frontiers in Cellular and Infection Microbiology
Influenza presents a significant public health threat, as severe cases can lead to excessive inflammation and complications such as pneumonia or acute respiratory distress syndrome.
Yarou Gao, Ge Liu, Yirui Ma, Yue Su, Xiaoqin Lian, Lefang Jiang, Jiaxin Ke, Xingjian Zhu, Mingxin Zhang, Yang Yu, Qun Peng, Wei Zhao, Wei Zhao, Xulin Chen   +13 more
doaj   +2 more sources

Drosophila modifier screens to identify novel neuropsychiatric drugs including aminergic agents for the possible treatment of Parkinson's disease and depression. [PDF]

Molecular Psychiatry, 2014
Small molecules that increase the presynaptic function of aminergic cells may provide neuroprotection in Parkinson's disease (PD) as well as treatments for attention deficit hyperactivity disorder (ADHD) and depression.
Biedermann, T, Chou, M-T, Djapri, C, Hadi, R, Huang, B, Jang, J, Krantz, DE, Lam, HA, Lawal, HO, Lawless, GM, Maidment, NT, Roberts, L, Shahi, V, Terrell, A   +13 more
core   +3 more sources

Strategies for sensing neurotransmitters with responsive MRI contrast agents

Chemical Society Reviews, 2017
A great deal of research involving multidisciplinary approaches is currently dedicated to the understanding of brain function. The complexity of physiological processes that underlie neural activity is the greatest hurdle to faster advances.
Goran Angelovski, Éva Tóth
openalex   +3 more sources

Nerve agent hydrolysis activity designed into a human drug metabolism enzyme. [PDF]

PLoS ONE, 2011
Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP poisoning.
Andrew C Hemmert, Tamara C Otto, Roberto A Chica, Monika Wierdl, Jonathan S Edwards, Steven M Lewis, Carol C Edwards, Lyudmila Tsurkan, C Linn Cadieux, Shane A Kasten, John R Cashman, Stephen L Mayo, Philip M Potter, Douglas M Cerasoli, Matthew R Redinbo   +14 more
doaj   +9 more sources

Current and Future Treatments in Alzheimer Disease: An Update

Journal of Central Nervous System Disease, 2020
Disease-modifying treatment strategies for Alzheimer disease (AD) are still under extensive research. Nowadays, only symptomatic treatments exist for this disease, all trying to counterbalance the neurotransmitter disturbance: 3 cholinesterase inhibitors
Konstantina G Yiannopoulou, Sokratis G Papageorgiou   +1 more
doaj   +2 more sources

An Acetylcholinesterase-Based Chronoamperometric Biosensor for Fast and Reliable Assay of Nerve Agents

Sensors, 2013
The enzyme acetylcholinesterase (AChE) is an important part of cholinergic nervous system, where it stops neurotransmission by hydrolysis of the neurotransmitter acetylcholine.
Rene Kizek, Vojtech Adam, Miroslav Pohanka   +2 more
doaj   +2 more sources

Antiepileptic potential of ganaxolone [PDF]

Vojnosanitetski Pregled, 2017
nema
Janković Slobodan, Lukić Snežana
doaj   +1 more source

Plastic reorganisation of human motor cortex [PDF]

Vojnosanitetski Pregled, 2012
nema
Ilić Tihomir V., Ilić Nela V.
doaj   +1 more source