Bioluminescence-based high-throughput screen identifies pharmacological agents that target neurotransmitter signaling in small cell lung carcinoma. [PDF]
PLoS ONE, 2011 BACKGROUND: Frontline treatment of small cell lung carcinoma (SCLC) relies heavily on chemotherapeutic agents and radiation therapy. Though SCLC patients respond well to initial cycles of chemotherapy, they eventually develop resistance.
Ma Reina D Improgo +3 more
doaj +3 more sources
Screening of neurotransmitter receptor modulators reveals novel inhibitors of influenza virus replication [PDF]
Frontiers in Cellular and Infection MicrobiologyInfluenza presents a significant public health threat, as severe cases can lead to excessive inflammation and complications such as pneumonia or acute respiratory distress syndrome.
Yarou Gao +13 more
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Nerve agent hydrolysis activity designed into a human drug metabolism enzyme. [PDF]
PLoS ONE, 2011 Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP poisoning.
Andrew C Hemmert +14 more
doaj +9 more sources
Antiepileptic potential of ganaxolone [PDF]
Vojnosanitetski Pregled, 2017 nema
Janković Slobodan, Lukić Snežana
doaj +1 more source
Plastic reorganisation of human motor cortex [PDF]
Vojnosanitetski Pregled, 2012 nema
Ilić Tihomir V., Ilić Nela V.
doaj +1 more source
Reviewing the mechanism of propofol addiction
All Life, 2023 Propofol is widely used as a short-acting intravenous anaesthetic for the induction and maintenance of anaesthetic sedation. The application of propofol is expanding due to its advantages and the increasing demand for painless diagnosis and treatment ...
Tianhao Zhong +5 more
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High concentration of dopamine treatment may induce acceleration of human sperm motility
Reproductive Medicine and Biology, 2022 Purpose In humans, catecholamines (including dopamine) have been identified in semen and fallopian tubes, while dopamine D2 receptors (D2DR) are found in the sperm midpiece region.
Hiroki Kanno +5 more
doaj +1 more source
Neurotransmitter Specific, Cellular-Resolution Functional Brain Mapping Using Receptor Coated Nanoparticles: Assessment of the Possibility. [PDF]
, 2015 Receptor coated resonant nanoparticles and quantum dots are proposed to provide a cellular-level resolution image of neural activities inside the brain. The functionalized nanoparticles and quantum dots in this approach will selectively bind to different
Forati, Ebrahim +5 more
core +6 more sources
Pathomechanisms of Non-Traumatic Acute Brain Injury in Critically Ill Patients
Medicina, 2020 Delirium, an acute alteration in mental status characterized by confusion, inattention and a fluctuating level of arousal, is a common problem in critically ill patients. Delirium prolongs hospital stay and is associated with higher mortality.
Wojciech Dabrowski +8 more
doaj +1 more source
Neuropharmacologic modulation of the melatonergic system
Exploration of Neuroscience, 2023 The circadian rhythm is a critical system that governs an organism’s functions in alignment with the light-dark cycle. Melatonin release from the pineal gland plays a crucial role in regulating the internal clock of the body.
Utku Aykan +3 more
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