Bioluminescence-based high-throughput screen identifies pharmacological agents that target neurotransmitter signaling in small cell lung carcinoma. [PDF]
PLoS ONE, 2011 BACKGROUND: Frontline treatment of small cell lung carcinoma (SCLC) relies heavily on chemotherapeutic agents and radiation therapy. Though SCLC patients respond well to initial cycles of chemotherapy, they eventually develop resistance.
Ma Reina D Improgo +3 more
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Glycine – an important neurotransmitter and cytoprotective agent [PDF]
Acta Anaesthesiologica Scandinavica, 2005 Background: Glycine, the simplest of the amino acids, is an essential component of important biological molecules, a key substance in many metabolic reactions, the major inhibitory neurotransmitter in the spinal cord and brain stem, and an anti‐inflammatory, cytoprotective, and immune modulating substance.Material and methods: Based on available ...
Rune Gundersen +4 more
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mSphere, 2021 Coxiella burnetii causes the debilitating disease Q fever in humans. This infection is difficult to treat with current antibiotics and can progress to long-term, potentially fatal infection in immunocompromised individuals or when treatment is delayed.
Marissa S. Fullerton +5 more
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Strategies for sensing neurotransmitters with responsive MRI contrast agents
Chemical Society Reviews, 2017 This review introduces current and potential chemistry approaches in molecular fMRI that allow direct imaging of neurotransmitters.
Goran Angelovski, Éva Tóth
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Nerve growth factor alters microtubule targeting agent-induced neurotransmitter release but not MTA-induced neurite retraction in sensory neurons [PDF]
Experimental Neurology, 2016 Peripheral neuropathy is a dose-limiting side effect of anticancer treatment with the microtubule-targeted agents (MTAs), paclitaxel and epothilone B (EpoB); however, the mechanisms by which the MTAs alter neuronal function and morphology are unknown. We previously demonstrated that paclitaxel alters neuronal sensitivity, in vitro, in the presence of ...
Sherry K. Pittman +2 more
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THE EFFECT OF THE CONVULSANT AGENT, CATECHOL, ON NEUROTRANSMITTER UPTAKE AND RELEASE IN RAT BRAIN SLICES [PDF]
British Journal of Pharmacology, 1981 The effect of catechol on uptake and K+‐stimulated release of γ‐aminobutyric acid (GABA), D‐aspartate, noradrenaline and acetylcholine has been studied in slices of cerebral cortex and thalamus. Low concentrations of catechol did not influence the uptake of any of the neurotransmitters in either brain area.
M. C. W. Minchin, Georgina Pearson
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A Neuro-Symbolic Multi-Agent Architecture for Digital Transformation of Psychological Support Systems via Artificial Neurotransmitters and Archetypal Reasoning [PDF]
AlgorithmsThe digital transformation in the treatment of mental health and emotional disharmony requires artificial intelligence architectures that overcome the limitations of purely neural approaches, such as temporal inconsistency, opacity, and lack of theoretical foundations.
Gerardo Iovane +2 more
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Pharmacological properties of centrally‐administered agents which interfere with neurotransmitter function: a comparison with the central depressant effects of ouabain [PDF]
British Journal of Pharmacology, 1973 Summary Centrally administered sodium diethyldithiocarbamate (DDC) produced hypothermia, central nervous depression and potentiation of the antinociceptive effect of morphine. These effects resemble those seen with centrally administered ouabain. Furthermore, the interactions of (+)‐amphetamine, desmethylimipramine and nialamide with DDC and ouabain ...
N.S. Doggett, P.S. Spencer
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RetS senses neurotransmitter norepinephrine and adrenergic agents to regulatePseudomonas aeruginosavirulence [PDF]
AbstractBacterial cells employ diverse mechanisms to perceive and respond to host-associated molecules, coordinate intracellular signal transduction, and engage in interkingdom communications. In this study, we firstly discovered that the adrenergic antagonist dronedarone (DDR) effectively suppresses quorum sensing (QS) and pathogenesis of the ...
Ying Zhou +12 more
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Biochemical and Biophysical Research Communications, 1990 The polypeptides PDGF, TGF alpha, and EGF have previously been shown by others to stimulate proliferation of fibroblasts and keratinocytes in the process of wound healing. Here we demonstrate that extracellular ATP, ADP or AMPPNP caused synergistic enhancement of DNA synthesis in 3T6 mouse fibroblasts and BALB/MK keratinocytes when combined with any of
Dingji Wang +2 more
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