Results 1 to 10 of about 170,105 (313)

Bioluminescence-based high-throughput screen identifies pharmacological agents that target neurotransmitter signaling in small cell lung carcinoma. [PDF]

open access: yesPLoS ONE, 2011
BACKGROUND: Frontline treatment of small cell lung carcinoma (SCLC) relies heavily on chemotherapeutic agents and radiation therapy. Though SCLC patients respond well to initial cycles of chemotherapy, they eventually develop resistance.
Ma Reina D Improgo   +3 more
doaj   +5 more sources

Antiepileptic potential of ganaxolone [PDF]

open access: yesVojnosanitetski Pregled, 2017
nema
Janković Slobodan, Lukić Snežana
doaj   +1 more source

Plastic reorganisation of human motor cortex [PDF]

open access: yesVojnosanitetski Pregled, 2012
nema
Ilić Tihomir V., Ilić Nela V.
doaj   +1 more source

Reviewing the mechanism of propofol addiction

open access: yesAll Life, 2023
Propofol is widely used as a short-acting intravenous anaesthetic for the induction and maintenance of anaesthetic sedation. The application of propofol is expanding due to its advantages and the increasing demand for painless diagnosis and treatment ...
Tianhao Zhong   +5 more
doaj   +1 more source

High concentration of dopamine treatment may induce acceleration of human sperm motility

open access: yesReproductive Medicine and Biology, 2022
Purpose In humans, catecholamines (including dopamine) have been identified in semen and fallopian tubes, while dopamine D2 receptors (D2DR) are found in the sperm midpiece region.
Hiroki Kanno   +5 more
doaj   +1 more source

Pathomechanisms of Non-Traumatic Acute Brain Injury in Critically Ill Patients

open access: yesMedicina, 2020
Delirium, an acute alteration in mental status characterized by confusion, inattention and a fluctuating level of arousal, is a common problem in critically ill patients. Delirium prolongs hospital stay and is associated with higher mortality.
Wojciech Dabrowski   +8 more
doaj   +1 more source

Neuropharmacologic modulation of the melatonergic system

open access: yesExploration of Neuroscience, 2023
The circadian rhythm is a critical system that governs an organism’s functions in alignment with the light-dark cycle. Melatonin release from the pineal gland plays a crucial role in regulating the internal clock of the body.
Utku Aykan   +3 more
doaj   +1 more source

Disminución del número de neuronas que expresan GABA en la corteza cerebral de ratones infectados con rabia

open access: yesBiomédica: revista del Instituto Nacional de Salud, 2007
Introducción. Algunos signos clínicos de la rabia y estudios experimentales previos sugieren que esta infección viral podría afectar al sistema GABAérgico. Objetivo. Evaluar el efecto de la infección con el virus de la rabia sobre la expresión de GABA en
Aura Caterine Rengifo   +1 more
doaj   +1 more source

Cognitive Decline in Neuronal Aging and Alzheimer's Disease: Role of NMDA Receptors and Associated Proteins

open access: yesFrontiers in Neuroscience, 2017
Molecular changes associated with neuronal aging lead to a decrease in cognitive capacity. Here we discuss these alterations at the level of brain regions, brain cells, and brain membrane and cytoskeletal proteins with an special focus in NMDA molecular ...
Jesús Avila   +13 more
doaj   +1 more source

Robot technology identifies a Parkinsonian therapeutics repurpose to target stem cells of glioblastoma

open access: yesCNS Oncology, 2020
Aim: Glioblastoma is a heterogeneous lethal disease, regulated by a stem-cell hierarchy and the neurotransmitter microenvironment. The identification of chemotherapies targeting individual cancer stem cells is a clinical need.
Andres Vargas-Toscano   +10 more
doaj   +1 more source

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