Results 1 to 10 of about 3,359,388 (281)

Strategies for sensing neurotransmitters with responsive MRI contrast agents

Chemical Society Reviews, 2017
A great deal of research involving multidisciplinary approaches is currently dedicated to the understanding of brain function. The complexity of physiological processes that underlie neural activity is the greatest hurdle to faster advances.
Goran Angelovski, Éva Tóth
semanticscholar   +10 more sources

Bioluminescence-based high-throughput screen identifies pharmacological agents that target neurotransmitter signaling in small cell lung carcinoma. [PDF]

PLoS ONE, 2011
BACKGROUND: Frontline treatment of small cell lung carcinoma (SCLC) relies heavily on chemotherapeutic agents and radiation therapy. Though SCLC patients respond well to initial cycles of chemotherapy, they eventually develop resistance.
Ma Reina D Improgo, Christopher W Johnson, Andrew R Tapper, Paul D Gardner   +3 more
doaj   +7 more sources

Glycine – an important neurotransmitter and cytoprotective agent [PDF]

Acta Anaesthesiologica Scandinavica, 2005
Background:  Glycine, the simplest of the amino acids, is an essential component of important biological molecules, a key substance in many metabolic reactions, the major inhibitory neurotransmitter in the spinal cord and brain stem, and an anti‐inflammatory, cytoprotective, and immune modulating substance.Material and methods:  Based on available ...
Rune Gundersen, Per Vaagenes, Torbjørn Breivik, Frode Fonnum, P. K. Opstad   +4 more
openalex   +4 more sources

The Relationship Between Dopamine Neurotransmitter Dynamics and the Blood-Oxygen-Level-Dependent (BOLD) Signal: A Review of Pharmacological Functional Magnetic Resonance Imaging

Frontiers in Neuroscience, 2018
Functional magnetic resonance imaging (fMRI) is widely used in investigations of normal cognition and brain disease and in various clinical applications. Pharmacological fMRI (pharma-fMRI) is a relatively new application, which is being used to elucidate
Tyler J. Bruinsma, Vidur V. Sarma, Vidur V. Sarma, Yoonbae Oh, Yoonbae Oh, Dong Pyo Jang, Su-Youne Chang, Su-Youne Chang, Greg A. Worrell, Val J. Lowe, Hang Joon Jo, Hang Joon Jo, Hoon-Ki Min, Hoon-Ki Min, Hoon-Ki Min   +14 more
doaj   +2 more sources

THE EFFECT OF THE CONVULSANT AGENT, CATECHOL, ON NEUROTRANSMITTER UPTAKE AND RELEASE IN RAT BRAIN SLICES [PDF]

British Journal of Pharmacology, 1981
The effect of catechol on uptake and K+‐stimulated release of γ‐aminobutyric acid (GABA), D‐aspartate, noradrenaline and acetylcholine has been studied in slices of cerebral cortex and thalamus. Low concentrations of catechol did not influence the uptake of any of the neurotransmitters in either brain area.
M. C. W. Minchin, Georgina Pearson
openalex   +4 more sources

Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells

mSphere, 2021
Coxiella burnetii causes the debilitating disease Q fever in humans. This infection is difficult to treat with current antibiotics and can progress to long-term, potentially fatal infection in immunocompromised individuals or when treatment is delayed.
Marissa S. Fullerton, Punsiri M. Colonne, Amanda L. Dragan, Katelynn R. Brann, Richard C. Kurten, Daniel E. Voth   +5 more
openalex   +4 more sources

Gammahydroxybutyrate: An overview of the pros and cons for it being a neurotransmitter and/or a useful therapeutic agent

Neuroscience & Biobehavioral Reviews, 1994
Gamma-hydroxybutyrate (GHB) is a catabolite in brain of gamma-aminobutyrate (GABA) and is also found in nonneuronal tissues. It is present in the brain at about one thousandth of the concentration of its parent compound. High affinity and specific uptake, and energy dependent transport systems for GHB have been described in brain in addition to a class
C. Cash
openalex   +4 more sources

Pharmacological properties of centrally-administered agents which interfere with neurotransmitter function: a comparison with the central depressant effects of ouabain [PDF]

British Journal of Pharmacology, 1973
Summary Centrally administered sodium diethyldithiocarbamate (DDC) produced hypothermia, central nervous depression and potentiation of the antinociceptive effect of morphine. These effects resemble those seen with centrally administered ouabain. Furthermore, the interactions of (+)‐amphetamine, desmethylimipramine and nialamide with DDC and ouabain ...
N.S. Doggett, P.S. Spencer
openalex   +3 more sources

Drosophila modifier screens to identify novel neuropsychiatric drugs including aminergic agents for the possible treatment of Parkinson's disease and depression. [PDF]

Molecular Psychiatry, 2014
Small molecules that increase the presynaptic function of aminergic cells may provide neuroprotection in Parkinson's disease (PD) as well as treatments for attention deficit hyperactivity disorder (ADHD) and depression.
Biedermann, T, Chou, M-T, Djapri, C, Hadi, R, Huang, B, Jang, J, Krantz, DE, Lam, HA, Lawal, HO, Lawless, GM, Maidment, NT, Roberts, L, Shahi, V, Terrell, A   +13 more
core   +3 more sources

Neurotransmitter amines and antioxidant agents in neuronal protection against methylmercury-induced cytotoxicity in primary cultures of mice cortical neurons [PDF]

NeuroToxicology, 2018
Methylmercury (MeHg) is an environmental toxicant with detrimental effects on the developing brain and adult nervous system. The main mechanisms identified include oxidative stress, changes in intracellular calcium, mitochondrial changes, inhibition of glutamate uptake, of protein synthesis and disruption of microtubules. However, little is known about
Nair Olguín, Marie-Lena Müller, Eduard Rodríguez‐Farré, Cristina Suñol   +3 more
openalex   +5 more sources