Nerve agent hydrolysis activity designed into a human drug metabolism enzyme. [PDF]
PLoS ONE, 2011 Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP poisoning.
Andrew C Hemmert +14 more
doaj +18 more sources
Bioluminescence-based high-throughput screen identifies pharmacological agents that target neurotransmitter signaling in small cell lung carcinoma. [PDF]
PLoS ONE, 2011 BACKGROUND: Frontline treatment of small cell lung carcinoma (SCLC) relies heavily on chemotherapeutic agents and radiation therapy. Though SCLC patients respond well to initial cycles of chemotherapy, they eventually develop resistance.
Ma Reina D Improgo +3 more
doaj +5 more sources
Antiepileptic potential of ganaxolone [PDF]
Vojnosanitetski Pregled, 2017 nema
Janković Slobodan, Lukić Snežana
doaj +1 more source
Plastic reorganisation of human motor cortex [PDF]
Vojnosanitetski Pregled, 2012 nema
Ilić Tihomir V., Ilić Nela V.
doaj +1 more source
Reviewing the mechanism of propofol addiction
All Life, 2023 Propofol is widely used as a short-acting intravenous anaesthetic for the induction and maintenance of anaesthetic sedation. The application of propofol is expanding due to its advantages and the increasing demand for painless diagnosis and treatment ...
Tianhao Zhong +5 more
doaj +1 more source
High concentration of dopamine treatment may induce acceleration of human sperm motility
Reproductive Medicine and Biology, 2022 Purpose In humans, catecholamines (including dopamine) have been identified in semen and fallopian tubes, while dopamine D2 receptors (D2DR) are found in the sperm midpiece region.
Hiroki Kanno +5 more
doaj +1 more source
Pathomechanisms of Non-Traumatic Acute Brain Injury in Critically Ill Patients
Medicina, 2020 Delirium, an acute alteration in mental status characterized by confusion, inattention and a fluctuating level of arousal, is a common problem in critically ill patients. Delirium prolongs hospital stay and is associated with higher mortality.
Wojciech Dabrowski +8 more
doaj +1 more source
Neuropharmacologic modulation of the melatonergic system
Exploration of Neuroscience, 2023 The circadian rhythm is a critical system that governs an organism’s functions in alignment with the light-dark cycle. Melatonin release from the pineal gland plays a crucial role in regulating the internal clock of the body.
Utku Aykan +3 more
doaj +1 more source
Drosophila modifier screens to identify novel neuropsychiatric drugs including aminergic agents for the possible treatment of Parkinson's disease and depression. [PDF]
, 2014 Small molecules that increase the presynaptic function of aminergic cells may provide neuroprotection in Parkinson's disease (PD) as well as treatments for attention deficit hyperactivity disorder (ADHD) and depression.
Biedermann, T +13 more
core +2 more sources
Biomédica: revista del Instituto Nacional de Salud, 2007 Introducción. Algunos signos clínicos de la rabia y estudios experimentales previos sugieren que esta infección viral podría afectar al sistema GABAérgico. Objetivo. Evaluar el efecto de la infección con el virus de la rabia sobre la expresión de GABA en
Aura Caterine Rengifo +1 more
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