Results 1 to 10 of about 119,386 (177)

Bioluminescence-based high-throughput screen identifies pharmacological agents that target neurotransmitter signaling in small cell lung carcinoma. [PDF]

PLoS ONE, 2011
BACKGROUND: Frontline treatment of small cell lung carcinoma (SCLC) relies heavily on chemotherapeutic agents and radiation therapy. Though SCLC patients respond well to initial cycles of chemotherapy, they eventually develop resistance.
Ma Reina D Improgo, Christopher W Johnson, Andrew R Tapper, Paul D Gardner   +3 more
doaj   +8 more sources

THE EFFECT OF THE CONVULSANT AGENT, CATECHOL, ON NEUROTRANSMITTER UPTAKE AND RELEASE IN RAT BRAIN SLICES [PDF]

British Journal of Pharmacology, 1981
The effect of catechol on uptake and K+‐stimulated release of γ‐aminobutyric acid (GABA), D‐aspartate, noradrenaline and acetylcholine has been studied in slices of cerebral cortex and thalamus. Low concentrations of catechol did not influence the uptake of any of the neurotransmitters in either brain area.
M. C. W. Minchin, Georgina Pearson
openalex   +4 more sources

Glycine – an important neurotransmitter and cytoprotective agent [PDF]

Acta Anaesthesiologica Scandinavica, 2005
Background:  Glycine, the simplest of the amino acids, is an essential component of important biological molecules, a key substance in many metabolic reactions, the major inhibitory neurotransmitter in the spinal cord and brain stem, and an anti‐inflammatory, cytoprotective, and immune modulating substance.Material and methods:  Based on available ...
Rune Gundersen, Per Vaagenes, Torbjørn Breivik, Frode Fonnum, P. K. Opstad   +4 more
openalex   +3 more sources

Strategies for sensing neurotransmitters with responsive MRI contrast agents

Chemical Society Reviews, 2017
This review introduces current and potential chemistry approaches in molecular fMRI that allow direct imaging of neurotransmitters.
Goran Angelovski, Éva Tóth
openalex   +6 more sources

Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells

mSphere, 2021
Coxiella burnetii causes the debilitating disease Q fever in humans. This infection is difficult to treat with current antibiotics and can progress to long-term, potentially fatal infection in immunocompromised individuals or when treatment is delayed.
Marissa S. Fullerton, Punsiri M. Colonne, Amanda L. Dragan, Katelynn R. Brann, Richard C. Kurten, Daniel E. Voth   +5 more
openalex   +4 more sources

Effects of Z-338, a novel gastroprokinetic agent, on the actions of excitatory and inhibitory neurotransmitters on neurons in area postrema

Journal of Smooth Muscle Research, 2010
We investigated the effects of the novel gastroprokinetic agent Z-338 on the actions of excitatory and inhibitory neurotransmitters on neurons in area postrema (AP). Iontophoretic applications of acetylcholine (ACh), AMPA and NMDA increased, while GABA suppressed the firing rates of AP neurons recorded by extracellular electrodes.
Hironari Akaike, I‐S Jang, Nobuaki Hori, Sachie K. Ogawa, Yushi Ito, Norio Akaike   +5 more
openalex   +4 more sources

Pharmacological properties of centrally‐administered agents which interfere with neurotransmitter function: a comparison with the central depressant effects of ouabain [PDF]

British Journal of Pharmacology, 1973
Summary Centrally administered sodium diethyldithiocarbamate (DDC) produced hypothermia, central nervous depression and potentiation of the antinociceptive effect of morphine. These effects resemble those seen with centrally administered ouabain. Furthermore, the interactions of (+)‐amphetamine, desmethylimipramine and nialamide with DDC and ouabain ...
N.S. Doggett, P.S. Spencer
openalex   +4 more sources

Reliability of behavioral test with fish: How neurotransmitters may exert neuromodulatory effects and alter the biological responses to neuroactive agents

Science of The Total Environment, 2020
Toxic agents such as pharmaceuticals and pesticides are continuously dispersed especially in the aquatic environment, as a result of human use. Their presence in the environment presents serious concerns, since these compounds interfere with the normal function of the central nervous system (CNS), causing behavior alterations, whose consequences are ...
Beatriz Sousa, Bruno Nunes
openalex   +4 more sources

Extracellular ATP shows synergistic enhancement of DNA synthesis when combined with agents that are active in wound healing or as neurotransmitters

Biochemical and Biophysical Research Communications, 1990
The polypeptides PDGF, TGF alpha, and EGF have previously been shown by others to stimulate proliferation of fibroblasts and keratinocytes in the process of wound healing. Here we demonstrate that extracellular ATP, ADP or AMPPNP caused synergistic enhancement of DNA synthesis in 3T6 mouse fibroblasts and BALB/MK keratinocytes when combined with any of
Dingji Wang, Ning‐Na Huang, Leon Heppel   +2 more
openalex   +3 more sources

Neurotransmitter amines and antioxidant agents in neuronal protection against methylmercury-induced cytotoxicity in primary cultures of mice cortical neurons

NeuroToxicology, 2018
Methylmercury (MeHg) is an environmental toxicant with detrimental effects on the developing brain and adult nervous system. The main mechanisms identified include oxidative stress, changes in intracellular calcium, mitochondrial changes, inhibition of glutamate uptake, of protein synthesis and disruption of microtubules. However, little is known about
Nair Olguín, Marie-Lena Müller, Eduard Rodrı́guez-Farré, Cristina Suñol   +3 more
openalex   +5 more sources