Glycine – an important neurotransmitter and cytoprotective agent [PDF]
Acta Anaesthesiologica Scandinavica, 2005 Background: Glycine, the simplest of the amino acids, is an essential component of important biological molecules, a key substance in many metabolic reactions, the major inhibitory neurotransmitter in the spinal cord and brain stem, and an anti‐inflammatory, cytoprotective, and immune modulating substance.Material and methods: Based on available ...
Rune Gundersen +4 more
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THE EFFECT OF THE CONVULSANT AGENT, CATECHOL, ON NEUROTRANSMITTER UPTAKE AND RELEASE IN RAT BRAIN SLICES [PDF]
British Journal of Pharmacology, 1981 The effect of catechol on uptake and K+‐stimulated release of γ‐aminobutyric acid (GABA), D‐aspartate, noradrenaline and acetylcholine has been studied in slices of cerebral cortex and thalamus. Low concentrations of catechol did not influence the uptake of any of the neurotransmitters in either brain area.
M. C. W. Minchin, Georgina Pearson
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mSphere, 2021 Coxiella burnetii causes the debilitating disease Q fever in humans. This infection is difficult to treat with current antibiotics and can progress to long-term, potentially fatal infection in immunocompromised individuals or when treatment is delayed.
Marissa S. Fullerton +5 more
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Pharmacological properties of centrally‐administered agents which interfere with neurotransmitter function: a comparison with the central depressant effects of ouabain [PDF]
British Journal of Pharmacology, 1973 Summary Centrally administered sodium diethyldithiocarbamate (DDC) produced hypothermia, central nervous depression and potentiation of the antinociceptive effect of morphine. These effects resemble those seen with centrally administered ouabain. Furthermore, the interactions of (+)‐amphetamine, desmethylimipramine and nialamide with DDC and ouabain ...
N.S. Doggett, P.S. Spencer
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Nerve growth factor alters microtubule targeting agent-induced neurotransmitter release but not MTA-induced neurite retraction in sensory neurons [PDF]
Experimental Neurology, 2016 Peripheral neuropathy is a dose-limiting side effect of anticancer treatment with the microtubule-targeted agents (MTAs), paclitaxel and epothilone B (EpoB); however, the mechanisms by which the MTAs alter neuronal function and morphology are unknown. We previously demonstrated that paclitaxel alters neuronal sensitivity, in vitro, in the presence of ...
Sherry K. Pittman +2 more
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RetS senses neurotransmitter norepinephrine and adrenergic agents to regulate Pseudomonas aeruginosa virulence [PDF]
AbstractBacterial cells employ diverse mechanisms to perceive and respond to host-associated molecules, coordinate intracellular signal transduction, and engage in interkingdom communications. In this study, we firstly discovered that the adrenergic antagonist dronedarone (DDR) effectively suppresses quorum sensing (QS) and pathogenesis of the ...
Ying Zhou +12 more
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High concentration of dopamine treatment may induce acceleration of human sperm motility
Reproductive Medicine and Biology, 2022 Purpose In humans, catecholamines (including dopamine) have been identified in semen and fallopian tubes, while dopamine D2 receptors (D2DR) are found in the sperm midpiece region.
Hiroki Kanno +5 more
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Neuropharmacologic modulation of the melatonergic system
Exploration of Neuroscience, 2023 The circadian rhythm is a critical system that governs an organism’s functions in alignment with the light-dark cycle. Melatonin release from the pineal gland plays a crucial role in regulating the internal clock of the body.
Utku Aykan +3 more
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A Neuro-Symbolic Multi-Agent Architecture for Digital Transformation of Psychological Support Systems via Artificial Neurotransmitters and Archetypal Reasoning [PDF]
AlgorithmsThe digital transformation in the treatment of mental health and emotional disharmony requires artificial intelligence architectures that overcome the limitations of purely neural approaches, such as temporal inconsistency, opacity, and lack of theoretical foundations.
Gerardo Iovane +2 more
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Counteracting Poisoning with Chemical Warfare Nerve Agents
Arhiv za Higijenu Rada i Toksikologiju, 2020 Phosphylation of the pivotal enzyme acetylcholinesterase (AChE) by nerve agents (NAs) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of ...
N. M. Hrvat, Z. Kovarik
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