Results 21 to 30 of about 170,105 (313)

Fluoxetine: a case history of its discovery and preclinical development [PDF]

, 2014
Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N, Bergstrom RF, Bravo L, Bremner JD, Burrows GD, Chouinard G, Datla KP, Esther Berrocoso, Juan Antonio Mico, Kreiss DS, Laura Perez-Caballero, Lemberger L, Li Q, Lidia Bravo, Maj J, Nibuya M, Owens MJ, Rutter JJ, Sonia Torres-Sanchez, Stevens JC, Wong DT   +20 more
core   +2 more sources

Neurochemical Modulating Effect of Boswellia serrata Roxb. ex Colebr: A Preclinical Research

Pharmaceutical and Biomedical Research, 2022
Background: Boswellia serrata has been known for many decades and mentioned in the ancient Ayurvedic texts. Many previous studies have demonstrated its role in depression and anxiety in animal models.
Prabhakar Adake, Mahalaxmi S Petimani, Greeshma B Kotian   +2 more
doaj  

Elucidating the Role of Neurotensin in the Pathophysiology and Management of Major Mental Disorders

Behavioral Sciences, 2014
Neurotensin (NT) is a neuropeptide that is closely associated with, and is thought to modulate, dopaminergic and other neurotransmitter systems involved in the pathophysiology of various mental disorders.
Mona M Boules, Paul Fredrickson, Amber M Muehlmann, Elliott Richelson   +3 more
doaj   +1 more source

Mechanism of lily bulb and Rehmannia decoction in the treatment of lipopolysaccharide-induced depression-like rats based on metabolomics study and network pharmacology

Pharmaceutical Biology, 2022
Context Lily bulb and Rehmannia decoction (LBRD), consisting of Lilium henryi Baker (Liliaceae) and Rehmannia glutinosa (Gaertn) DC (Plantaginaceae), is a specialized traditional Chinese medicine formula for treating depression.
Xiansu Chi, Xiaoyan Xue, Jin Pan, Jiang Wu, Huishan Shi, Yong Wang, Yanting Lu, Zhe Zhang, Ke Ma   +8 more
doaj   +1 more source

The Relationship Between Dopamine Neurotransmitter Dynamics and the Blood-Oxygen-Level-Dependent (BOLD) Signal: A Review of Pharmacological Functional Magnetic Resonance Imaging

Frontiers in Neuroscience, 2018
Functional magnetic resonance imaging (fMRI) is widely used in investigations of normal cognition and brain disease and in various clinical applications. Pharmacological fMRI (pharma-fMRI) is a relatively new application, which is being used to elucidate
Tyler J. Bruinsma, Vidur V. Sarma, Vidur V. Sarma, Yoonbae Oh, Yoonbae Oh, Dong Pyo Jang, Su-Youne Chang, Su-Youne Chang, Greg A. Worrell, Val J. Lowe, Hang Joon Jo, Hang Joon Jo, Hoon-Ki Min, Hoon-Ki Min, Hoon-Ki Min   +14 more
doaj   +1 more source

Quantitative Structure-Activity Relationship (QSAR) Studies and Molecular docking Simulation of Norepinephrine Transporter (NET) Inhibitors as Anti-psychotic Therapeutic Agents

Journal of the Turkish Chemical Society, Section A: Chemistry, 2020
The Norepinephrine transporter (NET) is a Na+/Cl- coupled neurotransmitter transporter responsible for reuptake of released norepinephrine (NE) into neural terminals in the brain, an important therapeutic agent used in the treatment of psychiatric ...
Sabitu Babatunde OLASUPO, Adamu UZAIRU, Gideon SHALLANGWA, Sani UBA   +3 more
doaj   +1 more source

The influence of non-neuronal cells on catecholamine and acetylcholine synthesis and accumulation in cultures of dissociated sympathetic neurons [PDF]

, 1974
The effects of several non-neuronal cell types on neurotransmitter synthesis in cultures of dissociated sympathetic neurons from the new-born rat were studied.
Chun, Linda L. Y., Patterson, Paul H.
core   +1 more source

Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases

Antioxidants, 2021
Neurotransmitter depletion and mitochondrial dysfunction are among the multiple pathological events that lead to neurodegeneration. Following our previous studies related with the development of multitarget mitochondriotropic antioxidants, this study ...
Daniel Chavarria, Ophelie Da Silva, Sofia Benfeito, Sandra Barreiro, Jorge Garrido, Fernando Cagide, Pedro Soares, Fernando Remião, Xavier Brazzolotto, Florian Nachon, Paulo J. Oliveira, José Dias, Fernanda Borges   +12 more
doaj   +1 more source

Could dopamine agonists aid in drug development for anorexia nervosa? [PDF]

, 2014
Anorexia nervosa is a severe psychiatric disorder most commonly starting during the teenage-years and associated with food refusal and low body weight. Typically there is a loss of menses, intense fear of gaining weight, and an often delusional quality ...
Frank, Guido KW
core   +2 more sources

Neuropharmacological targets for drug action in vestibular sensory pathways [PDF]

, 2017
The use of pharmacological agents is often the preferred approach to the management of vestibular dysfunction. In the vestibular sensory pathways, the sensory neuroepithelia are thought to be influenced by a diverse number of neuroactive substances that ...
Jones, Timothy A, Lee, Choongheon
core   +3 more sources