Results 51 to 60 of about 165,229 (327)

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Treatment of Erectile Dysfunction: Update

American Journal of Men's Health, 2007
Erectile dysfunction (ED) is the inability to achieve and maintain an erection. Erectile function is dependent upon complex interactions of neural and vascular pathways.
Rupesh Raina, Geetu Pahlajani, Ashok Agarwal, Craig D. Zippe   +3 more
doaj   +1 more source

Current Advances in Allosteric Modulation of Muscarinic Receptors

Biomolecules, 2020
Allosteric modulators are ligands that bind to a site on the receptor that is spatially separated from the orthosteric binding site for the endogenous neurotransmitter.
Jan Jakubik, Esam E. El-Fakahany
doaj   +1 more source

Cannabis sativa and the endogenous cannabinoid system: therapeutic potential for appetite regulation [PDF]

, 2011
The herb Cannabis sativa (C. sativa) has been used in China and on the Indian subcontinent for thousands of years as a medicine. However, since it was brought to the UK and then the rest of the western world in the late 19th century, its use has been a ...
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core   +3 more sources

Infrared Neural Stimulation Elicits Distinct Molecular Pathways in Astrocytes Based on Laser Pulse Parameters

Advanced Biology, EarlyView.
Infrared (IR) light evokes distinct calcium and water transport responses in astrocytes, depending on stimulation duration and protocol. This study uses widefield imaging and pharmacology to reveal differential engagement of astroglial signaling pathways.
Wilson R. Adams, Ana I Borrachero‐Conejo, Pratheepa Kumari Rasiah, Emanuela Saracino, Roberto Zamboni, Eric Duco Jansen, Valentina Benfenati, Anita Mahadevan‐Jansen   +7 more
wiley   +1 more source

ADMET and Druglikeness Calculations of Sarin, Soman, and Their Hypothetical Derivatives

Iraqi Journal of Industrial Research, 2022
Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) represents a numerical classification of any chemical to be a drug candidate with promising therapeutic efficacy with minimum toxicity or sensitivity depending on its chemical ...
Kafa Khalaf Hammud
doaj   +1 more source

Evaluation of antimotility effect of Lantana camara L. var. acuelata constituents on neostigmine induced gastrointestinal transit in mice [PDF]

, 2005
BACKGROUND: Lantana camara L. (Verbenaceae), a widely growing shrub which is toxic to some animal species, has been used in the traditional medicine for treating many ailments.
Ojha, Sudarshan, Sagar, Lenika, Sehgal, Rajesh   +2 more
core   +2 more sources

Transducer Materials Mediated Deep Brain Stimulation in Neurological Disorders

Advanced Functional Materials, EarlyView.
This review discusses advanced transducer materials for improving deep brain stimulation (DBS) in neurological disorders. These materials respond to light, ultrasound, or magnetic fields, enabling precise, less invasive neuromodulation. Their stimulus‐responsive properties enhance neural control and adaptive therapy, paving the way for next‐generation ...
Di Zhao, Zhengyang Cao, Guangjun Zhong, Limin Shi, Junxia Xie, Jianhua Hao   +5 more
wiley   +1 more source

Clinical Efficacy and Therapeutic Mechanism of Acupuncture in the Treatment of Adolescent Depression

Journal of Integrative Neuroscience
Background: Pharmacological treatment for adolescent depression is limited in safety and efficacy. Acupuncture treatment for depression has been endorsed by the World Health Organization.
Jinlan Jiang, Baohua Ji, Wei Jin, Peiyun Zhang, Haoran Chen, Wenjie Cong, Xiaoqing Jin, Lihong Li   +7 more
doaj   +1 more source

Blockade of Intranigral and Systemic D3 Receptors Stimulates Motor Activity in the Rat Promoting a Reciprocal Interaction among Glutamate, Dopamine, and GABA

Biomolecules, 2019
In vivo activation of dopamine D3 receptors (D3Rs) depresses motor activity. D3Rs are widely expressed in subthalamic, striatal, and dendritic dopaminergic inputs into the substantia nigra pars reticulata (SNr).
Marina Rodríguez-Sánchez, Rodrigo Erick Escartín-Pérez, Gerardo Leyva-Gómez, José Arturo Avalos-Fuentes, Francisco Javier Paz-Bermúdez, Santiago Iván Loya-López, Jorge Aceves, David Erlij, Hernán Cortés, Benjamín Florán   +9 more
doaj   +1 more source