Results 41 to 50 of about 4,508,815 (293)

The effect of physical exercise on circulating brain‐derived neurotrophic factor in healthy subjects: A meta‐analysis of randomized controlled trials

Brain and Behavior, 2022
Objective To investigate how physical exercise (PE) would affect brain‐derived neurotrophic factor (BDNF) in randomized controlled trials (RCTs) of healthy subjects.
Ya‐Hai Wang, Huan‐Huan Zhou, Qiang Luo, Sidong Cui   +3 more
doaj   +1 more source

RESTORATION OF MOTOR AND NON-MOTOR FUNCTIONS BY NEUROTROPHIC FACTORS IN NONHUMAN PRIMATES WITH DOPAMINE DEPLETION [PDF]

, 2013
Parkinson’s disease (PD) is a progressive debilitating neurodegenerative disorder characterized by resting tremor, rigidity, bradykinesia and postural instability. As the disease progresses there is a loss of dopamine (DA) neurons in the substantia nigra
Subramanian, Krishna
core  

Modeling Progressive Brain Volume Losses in Chronic Moderate Severe Traumatic Brain Injury: Extensive, but Attenuating

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progressive brain atrophy has now been widely observed in the chronic stages of moderate–severe traumatic brain injury (msTBI), but there is only coarse information regarding its prevalence and magnitude, and whether rate of atrophy accelerates or attenuates across time. We examined these questions in a Canadian inception cohort from
Robin E. A. Green, Brenda Colella, Alana Changoor, David J. Mikulis, Adrienne Li, Kadeen Johns, Georges A. Monette   +6 more
wiley   +1 more source

Elaphuri Davidiani Cornu Improves Depressive-Like Behavior in Mice and Increases Neurotrophic Factor Expression in Mouse Primary Astrocytes via cAMP and ERK-Dependent Pathways

Frontiers in Pharmacology, 2020
Elaphuri Davidiani Cornu (EDC) is the natural shedding horn of Elaphurus davidiauus Millne-Edwards that was used by people in ancient China for maintaining physical and mental health.
Yue Zhu, Mengqiu Liu, Suchen Qu, Cheng Cao, Chongqi Wei, Xue-er Meng, Qianyin Lou, Dawei Qian, Jin-ao Duan, Yuhua Ding, Zhengxiang Han, Ming Zhao   +11 more
doaj   +1 more source

Neurotrophic factor-based pharmacological approaches in neurological disorders

Neural Regeneration Research, 2023
Aging is a physiological event dependent on multiple pathways that are linked to lifespan and processes leading to cognitive decline. This process represents the major risk factor for aging-related diseases such as Alzheimer’s disease, Parkinson’s ...
Margherita Alfonsetti, Michele d’Angelo, Vanessa Castelli   +2 more
doaj   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Associations between brain-derived neurotrophic factor plasma levels and severity of the illness, recurrence and symptoms in depressed patients. [PDF]

, 2010
Background: There is an increasing evidence that the Brain-Derived Neurotrophic Factor (BDNF) could be involved in the pathophysiology of mood disorders and that its peripheral levels may represent a reliable mirror of its concentration in the brain. The
BIANCHI, CAROLINA
core  

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Brain-derived neurotrophic factor and mental disorders

Biomedical Journal, 2020
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that modulates neuroplasticity in the brain, and is one of the most widely investigated molecule in psychiatric disorders.
Chin-Chuen Lin, Tiao-Lai Huang
doaj   +1 more source

Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF) after acute psychosocial stress [PDF]

, 2012
Environmentally induced epigenetic alterations are related to mental health. We investigated quantitative DNA methylation status before and after an acute psychosocial stressor in two stress-related genes: oxytocin receptor (OXTR) and brain-derived ...
Dempster, E., Dempster, Emma, Unternaehrer, Eva, Lieb, Roselind, Meyer, A. H., Unternaehrer, E., Luers, P., Mill, J., Staehli, S., Hellhammer, D. H., Meyer, Andrea H., Lieb, R., Meinlschmidt, G., Staehli, Simon, Mill, John, Hellhammer, Dirk H., Meinlschmidt, Gunther, Luers P, Meinlschmidt G, Lieb R, Meyer AH, Dempster E, Staehli S, Hellhammer DH, Mill J, Unternaehrer E   +25 more
core   +1 more source