Results 1 to 10 of about 38,837 (169)

NGF in Neuropathic Pain: Understanding Its Role and Therapeutic Opportunities. [PDF]

Curr Issues Mol Biol
Nerve growth factor (NGF) is one of the essential components that have been implicated in the pathophysiology of neuropathic pain, a condition that develops following nerve injury or dysfunction.
García-Domínguez M.
europepmc   +2 more sources

Electrical, structural, and autonomic atrial remodeling underlies atrial fibrillation in inflammatory atrial cardiomyopathy

Frontiers in Cardiovascular Medicine, 2023
BackgroundThere is growing evidence indicating a close relationship between inflammation and atrial fibrillation (AF). Although underlying inflammatory atrial cardiomyopathy may contribute to the development of AF, the arrhythmogenic remodeling caused by
Yoshiko Murakata, Fumi Yamagami, Nobuyuki Murakoshi, DongZhu Xu, Zhonghu Song, Siqi Li, Yuta Okabe, Kazuhiro Aonuma, ZiXun Yuan, Haruka Mori, Kazutaka Aonuma, Kazuko Tajiri, Kazuko Tajiri, Masaki Ieda   +13 more
doaj   +1 more source

Rab10 regulates the sorting of internalised TrkB for retrograde axonal transport

eLife, 2023
Neurons process real-time information from axon terminals to coordinate gene expression, growth, and plasticity. Inputs from distal axons are encoded as a stream of endocytic organelles, termed signalling endosomes, targeted to the soma.
Oscar Marcelo Lazo, Giampietro Schiavo
doaj   +1 more source

Differential contribution of TrkB and p75NTR to BDNF-dependent self-renewal, proliferation, and differentiation of adult neural stem cells

Frontiers in Molecular Neuroscience, 2023
Alterations in adult neurogenesis are a common hallmark of neurodegenerative diseases. Therefore, understanding the molecular mechanisms that control this process is an indispensable requirement for designing therapeutic interventions addressing ...
Anna Lozano-Ureña, José M. Frade
doaj   +1 more source

A Deep Learning Approach to Optimize Recombinant Protein Production in Escherichia coli Fermentations

Fermentation, 2023
Fermentation is a widely used process in the biotechnology industry, in which sugar-based substrates are transformed into a new product through chemical reactions carried out by microorganisms.
Domenico Bonanni, Mattia Litrico, Waqar Ahmed, Pietro Morerio, Tiziano Cazzorla, Elisa Spaccapaniccia, Franca Cattani, Marcello Allegretti, Andrea Rosario Beccari, Alessio Del Bue, Franck Martin   +10 more
doaj   +1 more source

Oleuropein Promotes Neural Plasticity and Neuroprotection via PPARα-Dependent and Independent Pathways

Biomedicines, 2023
Oleuropein (OLE), a main constituent of olives, displays a pleiotropic beneficial dynamic in health and disease; the effects are based mainly on its antioxidant and hypolipidemic properties, and its capacity to protect the myocardium during ischemia ...
Foteini Malliou, Christina E. Andriopoulou, Aristeidis Kofinas, Allena Katsogridaki, George Leondaritis, Frank J. Gonzalez, Theologos M. Michaelidis, Marousa Darsinou, Leandros A. Skaltsounis, Maria Konstandi   +9 more
doaj   +1 more source

Association of peripheral manifestation of brain‐derived neurotrophic factor with depression: A meta‐analysis

Brain and Behavior, 2022
Background The relationship between brain‐derived neurotrophic factor (BDNF) and depression is a hot topic in research as several results of preclinical and clinical studies have shown controversial results.
Sagun Tiwari, Lili Qi, John Wong, Zhenxiang Han   +3 more
doaj   +1 more source

Alpha-pinene moderates memory impairment induced by kainic acid via improving the BDNF/TrkB/CREB signaling pathway in rat hippocampus

Frontiers in Molecular Neuroscience, 2023
IntroductionThe potential benefits of natural ingredients in the alleviation of neurodegenerative disorders are of great interest. Alpha-pinene (APN) is an essential oil belonging to monoterpenes with multiple beneficial effects.
Paria Hashemi, Shamseddin Ahmadi
doaj   +1 more source

Neuro-hormonal Regulation Is a Better Indicator of Human Cognitive Abilities Than Brain Anatomy: The Need for a New Paradigm

Frontiers in Neuroanatomy, 2020
Human intelligence has been theorized since the ancient Greeks. Plato and Aristotle incorporated theories of human intelligence into their metaphysical and cosmological theories which informed the social and medical sciences for centuries.
Arthur Saniotis, Arthur Saniotis, James P. Grantham, James P. Grantham, Jaliya Kumaratilake, Maciej Henneberg, Maciej Henneberg   +6 more
doaj   +1 more source

Administration of Beta-Nerve Growth Factor during the Preovulatory Stage Improves Endocrine and Luteal Function in Dairy Heifers

Animals, 2023
The neurotrophin beta-nerve growth factor (NGF), which is present in the semen of different mammals, elicits potent ovulatory and luteotrophic actions in llamas following systemic administration.
Gonzalo Gajardo, Luis Paiva, Cesar Ulloa-Leal, Ximena Valderrama, Gerardo López, Albert Carrasco, Alejandra Isabel Hidalgo, Mauricio E. Silva, Patricio I. Palma, Marcelo H. Ratto   +9 more
doaj   +1 more source