Results 1 to 10 of about 53,939 (243)
NGF in Neuropathic Pain: Understanding Its Role and Therapeutic Opportunities. [PDF]
Curr Issues Mol BiolNerve growth factor (NGF) is one of the essential components that have been implicated in the pathophysiology of neuropathic pain, a condition that develops following nerve injury or dysfunction.
García-Domínguez M.
europepmc +2 more sources
The extracellular domain of neurotrophin receptor p75 as a candidate biomarker for amyotrophic lateral sclerosis. [PDF]
PLoS ONE, 2014 Objective biomarkers for amyotrophic lateral sclerosis would facilitate the discovery of new treatments. The common neurotrophin receptor p75 is up regulated and the extracellular domain cleaved from injured neurons and peripheral glia in amyotrophic ...
Stephanie R Shepheard +4 more
doaj +2 more sources
Optimizing transport methods to preserve function of self-innervating muscle cells for laryngeal injection. [PDF]
Laryngoscope Investig OtolaryngolObjectives Recently, our laboratory has discovered a self‐innervating population of muscle cells, called motor endplate‐expressing cells (MEEs). The cells innately release a wide variety of neurotrophic factors into the microenvironment promoting ...
Kaefer SL +5 more
europepmc +2 more sources
The role of neurotrophic factors in retinal ganglion cell resiliency. [PDF]
Front Cell NeurosciMany retinal diseases are characterized by direct or indirect retinal ganglion cell (RGC) neurodegeneration. In glaucoma and optic nerve neuropathies, RGCs are the primary affected cells, whereas in photoreceptor dystrophies, RGC loss is secondary to the
Abraham AK, Telias M.
europepmc +2 more sources
Neurotrophins and Neurotrophin Receptors in Adult Brain Plasticity [PDF]
Neural Plasticity, 1992 Franz Hefti +7 more
openalex +3 more sources
The Molecular Effects of BDNF Synthesis on Skeletal Muscle: A Mini-Review
Frontiers in Physiology, 2022 The brain-derived neurotrophic factor (BDNF) is a member of the nerve growth factor family which is generated mainly by the brain. Its main role involve synaptic modulation, neurogenesis, neuron survival, immune regulation, myocardial contraction, and ...
I. Rentería +7 more
doaj +1 more source
Rab10 regulates the sorting of internalised TrkB for retrograde axonal transport
eLife, 2023 Neurons process real-time information from axon terminals to coordinate gene expression, growth, and plasticity. Inputs from distal axons are encoded as a stream of endocytic organelles, termed signalling endosomes, targeted to the soma.
Oscar Marcelo Lazo, Giampietro Schiavo
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2023 BackgroundThere is growing evidence indicating a close relationship between inflammation and atrial fibrillation (AF). Although underlying inflammatory atrial cardiomyopathy may contribute to the development of AF, the arrhythmogenic remodeling caused by
Yoshiko Murakata +13 more
doaj +1 more source
Crystals of the neurotrophins [PDF]
Protein Science, 1996 AbstractThe neurotrophins show a high degree of amino acid sequence homology, share similar solution properties, and display distinct but parallel functionalities. Here we report the crystallization and preliminary X‐ray characterization of three neurotrophins: brain‐derived neurotrophin, neurotrophin 3, and the heterodimer between brain‐derived ...
Robinson, R +3 more
openaire +3 more sources
Frontiers in Neuroanatomy, 2020 Human intelligence has been theorized since the ancient Greeks. Plato and Aristotle incorporated theories of human intelligence into their metaphysical and cosmological theories which informed the social and medical sciences for centuries.
Arthur Saniotis +6 more
doaj +1 more source