Results 1 to 10 of about 108 (108)
Crystals of the neurotrophins [PDF]
Protein Science, 1996 AbstractThe neurotrophins show a high degree of amino acid sequence homology, share similar solution properties, and display distinct but parallel functionalities. Here we report the crystallization and preliminary X‐ray characterization of three neurotrophins: brain‐derived neurotrophin, neurotrophin 3, and the heterodimer between brain‐derived ...
Robinson, R +3 more
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Neuron, 2002 The family of neurotrophic factors known as neurotrophins has yielded a series of surprises, both with regard to the broad extent of their functional roles and the remarkable complexity of their signaling mechanisms. The recent discovery that a neurotrophin precursor protein and its proteolytically processed products may differentially activate pro ...
Moses V. Chao, Mark Bothwell
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Neurotrophins and Neurotrophin Receptors in Proliferative Diabetic Retinopathy [PDF]
PLoS ONE, 2013 Neurotrophins (NTs) are emerging as important mediators of angiogenesis and fibrosis. We investigated the expression of the NTs nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4) and their receptors TrkA, TrkB, and TrkC in proliferative diabetic retinopathy (PDR).
Abu El-Asrar, Ahmed M. +8 more
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Neurotrophins and hyperalgesia [PDF]
Proceedings of the National Academy of Sciences, 1999 Nerve growth factor (NGF), a member of the neurotrophin family, is crucial for survival of nociceptive neurons during development. Recently, it has been shown to play an important role in nociceptive function in adults. NGF is up-regulated after inflammatory injury of the skin.
Lorne M. Mendell, X.-Q. Shu
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Current Allergy and Asthma Reports, 2018 Asthma is a chronic airway disease that affects more than 300 million people worldwide. Current treatment focuses on symptomatic relief by temporally dampening inflammation and relaxing the airway. Novel combative strategies against asthma and hopefully a cure are yet to be developed.
Juliana Barrios, Xingbin Ai
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Activation of Trk neurotrophin receptors in the absence of neurotrophins [PDF]
Proceedings of the National Academy of Sciences, 2001 Neurotrophins regulate neuronal cell survival and synaptic plasticity through activation of Trk receptor tyrosine kinases. Binding of neurotrophins to Trk receptors results in receptor autophosphorylation and downstream phosphorylation cascades.
Francis S. Lee, Moses V. Chao
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Respiratory Medicine, 2009 Background: Numerous studies have demonstrated evidence of oxidative stress in COPD, in both respiratory tract lining fluids and biopsies. Antioxidant response in airway inflammatory cells to a pro-oxidative environment is however poorly understood. We have previously demonstrated an enhanced antioxidant enzyme activity in macrophages from asthmatics ...
Charlotta Dagnell +6 more
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Neurotrophin Signaling in Medulloblastoma [PDF]
Cancers, 2020 Neurotrophins are a family of secreted proteins that act by binding to tropomyosin receptor kinase (Trk) or p75NTR receptors to regulate nervous system development and plasticity. Increasing evidence indicates that neurotrophins and their receptors in cancer cells play a role in tumor growth and resistance to treatment.
Amanda Thomaz +9 more
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Engineering the Future of Restorative Clinical Peripheral Nerve Surgery
Advanced Healthcare Materials, EarlyView.What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell +5 more
wiley +1 more source
Emerging Therapeutic Strategies for Hearing Loss
Advanced Therapeutics, EarlyView.Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han +9 more
wiley +1 more source