Results 31 to 40 of about 53,997 (300)
Transactivation of TrkB Receptors by Oxytocin and Its G Protein-Coupled Receptor
Frontiers in Molecular Neuroscience, 2022 Brain-derived Neurotrophic Factor (BDNF) binds to the TrkB tyrosine kinase receptor, which dictates the sensitivity of neurons to BDNF. A unique feature of TrkB is the ability to be activated by small molecules in a process called transactivation.
Mariela Mitre +18 more
doaj +1 more source
Round-window delivery of neurotrophin 3 regenerates cochlear synapses after acoustic overexposure
Scientific Reports, 2016 In acquired sensorineural hearing loss, such as that produced by noise or aging, there can be massive loss of the synaptic connections between cochlear sensory cells and primary sensory neurons, without loss of the sensory cells themselves.
Jun Suzuki, G. Corfas, M. Liberman
semanticscholar +1 more source
Graphene promotes axon elongation through local stall of Nerve Growth Factor signaling endosomes [PDF]
, 2020 Several works reported increased differentiation of neuronal cells grown on graphene; however, the molecular mechanism driving axon elongation on this material has remained elusive. Here, we study the axonal transport of nerve growth factor (NGF), the neurotrophin supporting development of peripheral neurons, as a key player in the time course of ...
arxiv +1 more source
Biomolecules, 2019 The spatial and temporal availability of cytokines, and the microenvironments this creates, is critical to tissue development and homeostasis. Creating concentration gradients in vitro using soluble proteins is challenging as they do not provide a self ...
Yuka Matsuzaki +11 more
doaj +1 more source
Neurotrophin signalling: novel insights into mechanisms and pathophysiology.
Clinical science, 2016 Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are prominent regulators of neuronal survival, growth and differentiation during development.
M. Mitre, Abigail Mariga, M. Chao
semanticscholar +1 more source
Neurotrophins and Neurotrophin Receptors in Proliferative Diabetic Retinopathy [PDF]
PLoS ONE, 2013 Neurotrophins (NTs) are emerging as important mediators of angiogenesis and fibrosis. We investigated the expression of the NTs nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4) and their receptors TrkA, TrkB, and TrkC in proliferative diabetic retinopathy (PDR).
Abu El-Asrar, Ahmed M. +8 more
openaire +5 more sources
Pathophysiology of Depression: Stingless Bee Honey Promising as an Antidepressant
Molecules, 2022 Depression is a debilitating psychiatric disorder impacting an individual’s quality of life. It is the most prevalent mental illness across all age categories, incurring huge socio-economic impacts.
Fatin Haniza Zakaria +3 more
doaj +1 more source
Recent advances in understanding neurotrophin signaling
F1000Research, 2016 The nerve growth factor family of growth factors, collectively known as neurotrophins, are evolutionarily ancient regulators with an enormous range of biological functions.
M. Bothwell
semanticscholar +1 more source
Neurotrophins and hyperalgesia [PDF]
Proceedings of the National Academy of Sciences, 1999 Nerve growth factor (NGF), a member of the neurotrophin family, is crucial for survival of nociceptive neurons during development. Recently, it has been shown to play an important role in nociceptive function in adults. NGF is up-regulated after inflammatory injury of the skin.
Lorne M. Mendell, X.-Q. Shu
openaire +3 more sources
Journal of Neuroscience, 1995 Chronic stress produces structural changes and neuronal damage especially in the hippocampus. Because neurotrophic factors affect neuron survival, we questioned whether they might be relevant to the heightened vulnerability of hippocampal neurons ...
Mark A. Smith +4 more
semanticscholar +1 more source