Results 31 to 40 of about 38,429 (260)
Pathophysiology of Depression: Stingless Bee Honey Promising as an Antidepressant
Molecules, 2022 Depression is a debilitating psychiatric disorder impacting an individual’s quality of life. It is the most prevalent mental illness across all age categories, incurring huge socio-economic impacts.
Fatin Haniza Zakaria +3 more
doaj +1 more source
Respiratory Medicine, 2009 Background: Numerous studies have demonstrated evidence of oxidative stress in COPD, in both respiratory tract lining fluids and biopsies. Antioxidant response in airway inflammatory cells to a pro-oxidative environment is however poorly understood. We have previously demonstrated an enhanced antioxidant enzyme activity in macrophages from asthmatics ...
Charlotta Dagnell +6 more
openaire +2 more sources
Neurotrophin Signaling in Medulloblastoma [PDF]
Cancers, 2020 Neurotrophins are a family of secreted proteins that act by binding to tropomyosin receptor kinase (Trk) or p75NTR receptors to regulate nervous system development and plasticity. Increasing evidence indicates that neurotrophins and their receptors in cancer cells play a role in tumor growth and resistance to treatment.
Amanda Thomaz +9 more
openaire +2 more sources
Biomedicines, 2022 Neurotrophins are growth factors that exert important neuroprotective effects by preventing neuronal death and synaptic loss. Nerve Growth Factor (NGF) acts through the activation of its high-affinity, pro-survival TrkA and low-affinity, pro-apoptotic ...
Thanasis Rogdakis +15 more
doaj +1 more source
Endogenous neurotrophin-3 promotes neuronal sprouting from dorsal root ganglia
Neural Regeneration Research, 2015 In the present study, we investigated the role of endogenous neurotrophin-3 in nerve terminal sprouting 2 months after spinal cord dorsal root rhizotomy.
Xu-yang Wang +8 more
doaj +1 more source
Cell Reports, 2013 Sensory axon development requires concerted actions of growth factors for the precise control of axonal outgrowth and target innervation. How developing sensory neurons integrate different cues is poorly understood.
Mattéa J. Finelli +3 more
doaj +1 more source
Correlation Between Irisin and Cognitive Functions in Alzheimer Dementia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The myokine irisin, a recent positive mediator of exercise in the brain, shows neuroprotective functions against Alzheimer's disease (AD). The association between irisin and cognition has never been explored in a biologically defined cohort of patients.
Patrizia Pignataro +12 more
wiley +1 more source
Genetic Dissection of Neurotrophin Signaling through the p75 Neurotrophin Receptor
Cell Reports, 2012 Structural determinants underlying signaling specificity in the tumor necrosis factor receptor superfamily (TNFRSF) are poorly characterized, and it is unclear whether different signaling outputs can be genetically dissociated.
Ioannis Charalampopoulos +5 more
doaj +1 more source
Engineering the Future of Restorative Clinical Peripheral Nerve Surgery
Advanced Healthcare Materials, EarlyView.What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell +5 more
wiley +1 more source
Epithelial to Mesenchymal Transition: A Mechanism that Fuels Cancer Radio/Chemoresistance
Cells, 2020 Epithelial to mesenchymal transition (EMT) contributes to tumor progression, cancer cell invasion, and therapy resistance. EMT is regulated by transcription factors such as the protein products of the SNAI gene family, which inhibits the expression of ...
József Dudás +4 more
doaj +1 more source