Results 31 to 40 of about 39,773 (265)
Advanced Healthcare Materials, EarlyView.A novel blood‐brain barrier‐penetrating terpolymer nanoparticle to deliver brain‐derived neurotrophic factor (BDNF) for the treatment of Alzheimer's disease (AD) is designed. The BDNF‐TPN significantly enhances BDNF accumulation in the brain following intravenous injection, reduces apoptosis and neuroinflammation, thus promoting neuronal survival and ...
Lily Yi Li +8 more
wiley +1 more source
Kocatepe Veterinary Journal, 2014 Nörotrofinler, nöronların sağkalımını ve fonksiyonlarını etkileyen, sinaptik fonksiyonu ve sinaptik plastisiteyi kontrol eden polipeptid yapılı büyüme faktör ailesidir. Nörotrofin ailesi üyeleri, sinir büyüme faktörü, beyin kaynaklı nörotrofik faktör, nörotrofin-3, nörotrofin-4/5, nörotrofin-6, ve nörotrofin7’dir.
KAZAK, Filiz, YARIM, Gül Fatma
openaire +4 more sources
Neurotrophins and Neurotrophin Receptors in Proliferative Diabetic Retinopathy
PLoS ONE, 2013 Neurotrophins (NTs) are emerging as important mediators of angiogenesis and fibrosis. We investigated the expression of the NTs nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4) and their receptors TrkA, TrkB, and TrkC in proliferative diabetic retinopathy (PDR).
Abu El-Asrar, Ahmed M. +8 more
openaire +4 more sources
Advanced Healthcare Materials, EarlyView.Few‐layered three dimansional conductive graphene foams are promising cytocompatible platforms to transdifferentiate mesenchymal stem cells into Schwann cell‐like phenotypes using electrical and microstructural cues. Applied electrical stimulation conditions resulted in activation of MAPK, neurotrphin and RAS signaling pathways that led to upregulation
Ekin G. Simsar +9 more
wiley +1 more source
Molecules, 2013 Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by extracellular senile plaques and intracellular neurofibrillary tangles in the brain.
Lu Zhang +5 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu +21 more
wiley +1 more source
Neuroplasticity and depression
Psychiatry and Clinical Psychopharmacology, 2021 The monoamine hypothesis claims that depression is a result of deficiency of serotonin and/or noradrenaline in the neuronal synapses of the central nervous system.
Dilek Gürpınar +2 more
doaj
Türk Biyokimya Dergisi, 2022 We aimed to evaluate the effects of acute and chronic aerobic exercise on cognitive function and depression levels in patients with Type 2 Diabetes Mellitus (T2DM) and the changes in related neurotrophic and metabotropic factors.
Cokar Dilek +4 more
doaj +1 more source
Advanced Science, EarlyView.Single‐nucleus RNA sequencing of mid‐gestation brains from fetuses with nonsyndromic cleft lip and palate reveals major disruptions in cell composition, cell‐to‐cell signaling, and gene regulation. The transcription factor MEF2C is identified as a central regulator of these changes and shows that lowering MEF2C impairs synapse formation, linking cleft ...
Liu‐Lin Xiong +19 more
wiley +1 more source
Advanced Science, EarlyView.This seminal study highlights the interwoven and tightly regulated functions of brain‐derived extracellular vesicles. Using microfluidics, proteomics, and AI‐based electric signal analyses of cortical brain explants, this work provides a useful resource dataset revealing the composition of human brain‐derived extracellular vesicles obtained from ...
Corentin Bernou +14 more
wiley +1 more source