Results 41 to 50 of about 55,877 (286)
Journal of Biological Chemistry, 2014 Background: The role of Trk neurotrophin receptors in glioma is unknown. Results: TrkB and TrkC are required for survival of brain tumor-initiating cells in the absence of EGF and FGF.
Samuel O. Lawn +10 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study establishes a bio‐electroceutical interface by synergizing engineered exosome‐derived biological signals with electroconductive microneedle‐delivered electrical cues, achieving dual‐pathway reprogramming of the diabetic neurovascular niches and accelerating wound healing. Abstract Diabetic wound healing remains a major clinical challenge due
Di Liu +5 more
wiley +1 more source
Advanced Science, EarlyView.This seminal study highlights the interwoven and tightly regulated functions of brain‐derived extracellular vesicles. Using microfluidics, proteomics, and AI‐based electric signal analyses of cortical brain explants, this work provides a useful resource dataset revealing the composition of human brain‐derived extracellular vesicles obtained from ...
Corentin Bernou +14 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2019 Neurotrophins (NTs) are a subset of the neurotrophic factor family. These growth factors were originally named based on the nerve growth functional assays used to identify them. NTs act as paracrine or autocrine factors for cells expressing NT receptors.
Horacio Uri Saragovi +7 more
doaj +1 more source
Disrupting CSPG‐Driven Microglia–Astrocyte Crosstalk Enables Scar‐Free Repair in Spinal Cord Injury
Advanced Science, EarlyView.This study identifies CSPGs as key drivers of glial scar maturation after spinal cord injury by reprogramming microglial metabolism and inducing astrocyte fibrosis. To address this, a reactive oxygen species‐responsive, reactive astrocyte‐targeted ChABC gene delivery system is designed to locally degrade CSPGs, precisely disrupt maladaptive glial ...
Yufei Zheng +10 more
wiley +1 more source
Effects of BDNF and PEC Nanoparticles on Osteocytes
Molecules, 2020 Bone substitute materials loaded with mediators that stimulate fracture healing are demanded in the clinical treatment in trauma surgery and orthopedics.
Thomas Leonhard Loy +5 more
doaj +1 more source
The Role of Rab Proteins in Neuronal Cells and in the Trafficking of Neurotrophin Receptors
Membranes, 2014 Neurotrophins are a family of proteins that are important for neuronal development, neuronal survival and neuronal functions. Neurotrophins exert their role by binding to their receptors, the Trk family of receptor tyrosine kinases (TrkA, TrkB, and TrkC)
C. Bucci, P. Alifano, Laura Cogli
semanticscholar +1 more source
Current Developments and Challenges in the Field of Biohybrid Neural Interfaces—A Scoping Review
Advanced Electronic Materials, EarlyView.This scoping review explores recent advancements and persistent challenges in biohybrid neural interfaces, which integrate living cells with electronic devices to improve neural communication and implant biocompatibility. The article highlights key innovations, methodological diversity, and translational barriers, providing a comprehensive synthesis ...
Yi‐Lin Yu +6 more
wiley +1 more source
Неврология, нейропсихиатрия, психосоматика, 2020 Temporal lobe epilepsy (TLE) is one of the most common and refractory forms of epilepsy, with a different etiology. According to experimental and clinical studies, the transformation of the normal pattern of brain neuron activity into paroxysmal is ...
Y. S. Panina +4 more
doaj
Neurotrophin Analog ENT-A044 Activates the p75 Neurotrophin Receptor, Regulating Neuronal Survival in a Cell Context-Dependent Manner [PDF]
, 2023 Marianna Papadopoulou +7 more
openalex +1 more source