Results 41 to 50 of about 53,997 (300)
Current Allergy and Asthma Reports, 2018 Asthma is a chronic airway disease that affects more than 300 million people worldwide. Current treatment focuses on symptomatic relief by temporally dampening inflammation and relaxing the airway. Novel combative strategies against asthma and hopefully a cure are yet to be developed.
Juliana Barrios, Xingbin Ai
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Biomedicines, 2022 Neurotrophins are growth factors that exert important neuroprotective effects by preventing neuronal death and synaptic loss. Nerve Growth Factor (NGF) acts through the activation of its high-affinity, pro-survival TrkA and low-affinity, pro-apoptotic ...
Thanasis Rogdakis +15 more
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The p75 neurotrophin receptor: at the crossroad of neural repair and death
Neural Regeneration Research, 2015 The strong repair and pro-survival functions of neurotrophins at their primary receptors, TrkA, TrkB and TrkC, have made them attractive candidates for treatment of nervous system injury and disease. However, difficulties with the clinical implementation
R. Meeker, Kimberly S Williams
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Biomolecules, 2023 Intracellular endosomal trafficking controls the balance between protein degradation and synthesis, i.e., proteostasis, but also many of the cellular signaling pathways that emanate from activated growth factor receptors after endocytosis.
Ryan J. Mulligan, Bettina Winckler
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Mechanisms and regulation of neurotrophin synthesis and secretion
Neurosciences, 2016 Neurotrophins are secreted proteins that are synthesized as pre-pro-neurotrophins on the rough endoplasmic reticulum, which are subsequently processed and then secreted as mature proteins.
M. Al-Qudah, Ahmed Al-Dwairi
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Activation of Trk neurotrophin receptors in the absence of neurotrophins [PDF]
Proceedings of the National Academy of Sciences, 2001 Neurotrophins regulate neuronal cell survival and synaptic plasticity through activation of Trk receptor tyrosine kinases. Binding of neurotrophins to Trk receptors results in receptor autophosphorylation and downstream phosphorylation cascades.
Francis S. Lee, Moses V. Chao
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Journal of Biological Chemistry, 2015 Background: Although polySia is known to retain neurotrophins, their releasing mechanism remains unknown. Results: PolySia present on the cell surface of microglia is rapidly cleared by Neu1 sialidase on exovesicles secreted upon inflammatory stimulus ...
Mizuki Sumida +10 more
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Neurotrophin Signaling in Medulloblastoma [PDF]
Cancers, 2020 Neurotrophins are a family of secreted proteins that act by binding to tropomyosin receptor kinase (Trk) or p75NTR receptors to regulate nervous system development and plasticity. Increasing evidence indicates that neurotrophins and their receptors in cancer cells play a role in tumor growth and resistance to treatment.
Amanda Thomaz +9 more
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Delayed intramuscular human neurotrophin-3 improves recovery in adult and elderly rats after stroke
Brain : a journal of neurology, 2015 Duricki et al. show that intramuscular delivery of human neurotrophin-3 induces corticospinal plasticity and locomotor recovery in adult and elderly rats 24 hours post-stroke.
Denise A. Duricki +13 more
semanticscholar +1 more source
Respiratory Medicine, 2009 Background: Numerous studies have demonstrated evidence of oxidative stress in COPD, in both respiratory tract lining fluids and biopsies. Antioxidant response in airway inflammatory cells to a pro-oxidative environment is however poorly understood. We have previously demonstrated an enhanced antioxidant enzyme activity in macrophages from asthmatics ...
Charlotta Dagnell +6 more
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