Results 81 to 90 of about 38,974 (303)
Investigating the mechanisms of capsicum in age‐related hearing loss: Based on network pharmacology
Eye &ENT Research, EarlyView.Abstract Background To explore the material basis and action mechanism of the chemical component gene of pepper on presbycusis, and to provide a reference for the traditional Chinese medicine treatment of age‐related hearing loss (ARHL). Methods The chemical composition and action targets of traditional Chinese medicine flavor of pepper were searched ...
Yan Wang +9 more
wiley +1 more source
5-HT<sub>7</sub> antagonists confer analgesia via suppression of neurotrophin overproduction in submucosal nerves of mouse models with visceral hypersensitivity. [PDF]
J PhysiolAbstract figure legend Schematic diagram of intestinal nerve abnormality underlying the mechanisms of visceral hypersensitivity. In physiological conditions with normal sensation, enteric neurons are situated in the submucosal and myenteric plexuses, and the spinal afferent fibres ramify within the enteric plexus. However, serotonin/5‐hydroxytryptamine
Lee TY +9 more
europepmc +2 more sources
The Influence of Schwann Cell Metabolism and Dysfunction on Axon Maintenance
Glia, EarlyView.Sensory neurons depend on Schwann cells for survival. Schwann cells provide energy for axons during rapid firing or after injury. Dysregulated metabolism in Schwann cells can lead to the production of neurotoxic lipids and axon degeneration. ABSTRACT Schwann cells are the glial cells in the peripheral nervous system responsible for the production of ...
Rose Follis +2 more
wiley +1 more source
Editorial: Novel therapeutic targets for lower urinary tract symptoms
Frontiers in Urology, 2023 Jianshu Ni, Baojun Gu, Naoki Yoshimura
doaj +1 more source
Glia Preserve Their Own Functions While Compensating for Neighboring Glial Cell Dysfunction
Glia, EarlyView.When cortex glia lose their interactions with neuronal cell bodies, all neighboring glia infiltrate the region to clear extra neuronal corpses. Even while compensating for nearby glial dysfunction, glia maintain their own phagocytic functions. ABSTRACT Glial cells are essential for nervous system development, homeostasis, and disease response, engaging
Allison N. Beachum +13 more
wiley +1 more source
Neurobiology of Disease, 2001 We examined whether brain damage after focal cortex trauma may be attenuated by adenoviral delivery of the glial cell line-derived neurotrophic factor (GDNF) gene.
Dirk M. Hermann +4 more
doaj +1 more source
Unraveling the Role of Ensheathing Cells and Perineural Fibroblasts in Olfactory Neurogenesis
Glia, EarlyView.OECs are similar to satellite glial cells. OECs react to neuronal injury by promoting lipid metabolism, but do not proliferate. OECs reduce gap junctions upon neuronal injury. Perineural fibroblasts also contribute to the injury response. ABSTRACT During development and following injury‐induced neurogenesis, olfactory ensheathing cells (OECs) envelope ...
Katja Senf +3 more
wiley +1 more source
Neurotrophin receptor genes are expressed in distinct patterns in developing dorsal root ganglia [PDF]
, 1993 Xiaojun Mu +3 more
openalex +1 more source
Neurotrophins and Psychiatric Disorders
, 2014 Increasing number of studies has during the last decade linked neurotrophic factors with the pathophysiology of neuropsychiatric disorders and with the mechanisms of action of drugs used for the treatment of these disorders. In particular, brain-derived neurotrophic factor BDNF and its receptor TrkB have been connected with the pathophysiology in mood ...
Eero Castrén, Eero Castrén
openaire +4 more sources
Head &Neck, EarlyView.ABSTRACT Background The NTRK fusion gene is detected in most salivary gland secretory carcinomas. While tropomyosin receptor kinase (TRK) inhibitors are used for various solid tumors with the fusion gene, there are no reports regarding TRK inhibitor use for unresectable parotid gland carcinomas that subsequently shrink and become resectable.
Arisa Nagano +11 more
wiley +1 more source